The Role of Hydrogen Sulfide (HS) in Epigenetic Regulation of Neurodegenerative Diseases: A Systematic Review.

This review explores the emerging role of hydrogen sulfide (HS) in modulating epigenetic mechanisms involved in neurodegenerative diseases. Accumulating evidence has begun to elucidate the multifaceted ways in which HS influences the epigenetic landscape and, subsequently, the progression of various neurodegenerative disorders, including Alzheimer's, Parkinson's, and Huntington's disease. HS can modulate key components of the epigenetic machinery, such as DNA methylation, histone modifications, and non-coding RNAs, impacting gene expression and cellular functions relevant to neuronal survival, inflammation, and synaptic plasticity.

Usefulness of the Edmonton Frail Scale in Assessing the Impact of Heart Failure on Frailty.

Background/aim: The association of frailty with heart failure (HF) is common in the elderly, and its presence is a poor prognostic factor; it increases the risk of falls, disability, hospitalization, and mortality. The aim of this prospective study was to assess the incidence of physical frailty in patients with HF and the role of physical exercise in improving physical performance.

Patients And Methods: A total of 141 patients with musculoskeletal pathology, aged over 65 years, who followed a specific physical training program were included.