[Features of secondary prevention of cardiovascular disease in elderly individuals with high cardiovascular risk.].

Studied the causes of the ineffectiveness of follow-up of elderly patients with pathology of the cardiovascular system with high cardiovascular risk. The necessity of an individual approach, the individual preventive counseling in the usual patient conditions, learning to use tools of self-control belonging to that particular patient. Conducting a «pharmacological control» every visit to an elderly patient at home or a visit to the clinic.

[Oral diseases structure in patients with diffuse liver lesions before and after transplantation].

Unlabelled: Purpose of the study was to identify dental risk factors for complications at the stage of rehabilitation adaptation in patients with diffuse liver lesions. The study included 52 patients with diffuse liver lesions aged 25-55 years, who were divided between two groups of 26 persons with different dental status, depending on the main disease stage of treatment.

Research Methods: Clinical, x-ray, morphological, analytical, statistical.

[Vitamin D deficiency as a risk factor for chronic non-infectious diseases.].

Vitamin D deficiency is an important risk factor for a number of chronic non-infectious diseases. The results of the study showed a high prevalence of vitamin D deficiency in patients with cardiovascular and bronchial obstruction diseases. Patients with coronary artery disease in association with hypertension were diagnosed with a vitamin D deficiency in 60% of cases, a pronounced deficiency in 40%; in patients with arterial hypertension - a vitamin D deficiency in 80%, and a pronounced deficit - in 20%; in patients with chronic obstructive pulmonary disease - vitamin D deficiency in 33%, and a pronounced deficit - in 67%; in patients with bronchial asthma - vitamin D deficiency in 75%, a severe deficit in 25%, and a vitamin D deficiency in 25% of the subjects.

[The problem of osteoporosis in patients with cardiovascular and broncho-obstructive disease].

The article deals with the problem of osteoporosis in patients with cardiovascular and broncho-obstructive disease. The risk factors and clinical functional features of osteoporosis are analyzed in patients with coronary heart disease, hypertension, chronic obstructive pulmonary disease, bronchial asthma. Indicators of bone mineral density in patients with cardiovascular and broncho-obstructive disease on average meet the criteria for osteopenia.

Age-Dependent Changes of the Temporal Order--Causes and Treatment.

This review summarizes current knowledge on deteriorations in temporal order with advanced age. Changes of the overt rhythms will be described but also their putative causes and possible treatments of the disturbances. In aging animals and humans, all rhythm characteristics change.

[Clinical and functional characteristics of chronic obstructive pulmonary disease in association with pathology of the cardiovascular system in persons of advanced age].

The study was aimed at clinic-functional features of chronic obstructive pulmonary disease (COPD) in association with an arterial hypertension and an ischemic heart disease in persons of advanced age. 69 women and 82 men have been examined through clinic-laboratory, functional and tool methods of inspection. Distinctions in frequency of combined pathologies in the group of women of advanced age have been revealed in comparison with men.

[Functional polymorphism of p53 and CCR5 genes in the long-lived of the Siberian region].

The P53 protein is a key regulator of modified-cell apoptosis. The functional oligonucleotide polymorphism of the p53 gene causes the substitution of arginine (Arg) for praline (Pro) in the codon 72. A reduced apoptotic activity of p53 and, as a consequence, development of oncology pathology is associated with the above polymorphism.

[Experience of studies of longevity phenomenon in Tiumen'. Health status of long-livers: influence of hereditary, ecological, climatic and social factors on life span].

Aging of population in Tyumen region and a growing number of long livers, marked in last decade, make research of medical and social aspects of this age persons actual. Complex examination of 84 persons (age 90-102 years) was made. High longevity of parents, absence of chronic internal diseases complications in them, mechanisms of adaptation to severe climatic conditions due to the long living in Tyumen region are important factors for determination of longevity phenomenon.

[Cell-membrane aspects of the pathogenesis of hypoxia in vibration disease induced by local vibration].

A study was made of the blood and tissue oxygen regime in patients with vibratory disease (VD) induced by local vibration and of the importance of lipid peroxidation (LPO) in oxygenation disorders. Venous hyperoxia, a decrease of the arteriovenous difference according to oxygen, the percentage of oxygen utilization by tissues, shift of the acid-base balance towards metabolic acidosis were established, attesting to tissue hypoxia that increased with the gravity of VD. The importance of a steady activation of LPO and depression of the antioxidant system in the pathogenesis of hypoxia associated with VD was supported by the correlation analysis data on oxygen balance and LPO, the functional and metabolic characteristics of red blood cells (according to the viscosity of red blood cell suspension and the content in the cells of SH-groups, lipoproteins and histidine) and platelets (according to aggregation in response to ADP and thrombin) as well as by the level of blood serum fluorescence.

[Treatment of vibration-induced disease with corinfar].

Examination results of corinphar efficacy in the treatment of 25 patients with vibration disease caused by local vibration of mean- and high-frequency range were described. The daily dose of corinphar was 30 mg, the course of treatment lasted 17-21 days. Positive effect was noted in 23 patients.