A Study of the Comparability of the Pharmacodynamic, Toxicological, and Pharmacokinetic Properties of the Reference Drug Pulmozyme® and the Biosimilar Drug Tigerase®.

The article presents the results of studies of the drug Tigerase® (inhalation solution manufactured by JSC GENERIUM, Russia), conducted to obtain evidence of its similarity (comparability) to the reference drug Pulmozyme® (inhalation solution, manufactured by Hoffmann-La Roche Ltd., Switzerland). Both drugs contain human recombinant deoxyribonuclease I (dornase alfa) as an active substance and are intended for the treatment of cystic fibrosis with pulmonary manifestations (mucoviscidosis).

[Role of the components of the S-layer in immunogenicity of Bacillus anthracis].

The immunogenicity of proteins Sap and EA1, contained in B. anthracis S-layer, was evaluated in experiments on laboratory animals. These proteins were found to produce protective effect and could be regarded as additional immunogenic factors.

[study of the virulence of a recombinant strain of Bacillus anthracis, obtained as a result of transductive transfer of chromosomal genes from a strain of Bacillus cereus].

Auxotrophic markers of B. anthracis strains differing them from other Bacillus representatives have been determined. Chromosome genes from prototrophic B.

[Correlation of the virulence of Bacillus anthracis with expression of signs, coded for by chromosomal genes].

Clonal analysis of Bacillus anthracis strains showed heterogeneity of the majority of populations by the proteolytic, hemolytic, and pigment-adsorbing activities. Phenotypes isolated within each population were subdivided into 4 subpopulations. The appearance of sub-populations of virulent and vaccine strains (B.

Characteristics of the cohort of workers at the Mayak nuclear complex.

At Branch No. 1 of the Russian State Research Center "Biophysics Institute", a registry has been created of workers at the "Mayak" Production Association, the first nuclear complex in Russia. This registry includes 18,830 persons hired at Mayak's nuclear reactors and radiochemical and plutonium production plant between 1948 and 1972.

[Contribution of determinants, located in Bacillus anthracis chromosomes, in realizing the pathogenic properties of the pathogen].

Comparative study of virulence of B. anthracis strains harbouring pXO1 and pXO2 plasmids in mice and guinea pigs showed that among six B. anthracis strains, three were 100-1000 times less virulent for guinea pigs.

Lung cancer risk due to exposure to incorporated plutonium.

An epidemiological study has been carried out among 1,479 male workers who started working at the "Mayak" Production Association in 1948-1958 and were exposed to external gamma radiation and plutonium aerosols. Lung cancer mortality for the follow-up period 1948-1993 has been analyzed. No statistically significant association of lung cancer mortality and external gamma-ray dose has been revealed in the range of accumulated doses of 0.

Mortality among personnel who worked at the Mayak complex in the first years of its operation.

Epidemiological studies revealed increased cancer mortality among persons who began working at the Mayak complex during the period 1948-1958. Estimation of cancer risk was carried out for the sites of cancer that showed increased mortality and dependence on dose of external gamma- or internal alpha-irradiation.

Mortality among workers with chronic radiation sickness.

This study is based on a registry containing medical and dosimetric data of the employees who began working at different plants of the Mayak nuclear complex between 1948 and 1958 who developed chronic radiation sickness. Mayak is the first nuclear weapons plutonium production enterprise built in Russia and includes nuclear reactors, a radiochemical plant for plutonium separation, and a plutonium production plant. Workers whose employment began between 1948 and 1958 exhibited a 6-28% incidence of chronic radiation sickness at the different facilities.

Mortality from external causes among the personnel of Mayak's radiochemical plant.

The mortality rate from accidents, poisoning, and traumas was analyzed in 12,806 persons who started work at the radiochemical plant from 1948 to 1972. 559 persons died from these causes, which corresponds to 21.1% of the total number of deaths.

Mortality from cardiovascular diseases among male workers at the radiochemical plant of the 'Mayak' complex.

An epidemiologic retrospective study was conducted on the basis of a personnel registry, including 9373 male workers who had started to work at the radiochemical plant during the period from 1948 to 1972, inclusive. Male mortality from cardiovascular disease proved to be 271.1 cases in 100,000 persons/year on average.

Mortality from malignancies of the hematopoietic and lymphatic tissues among personnel of the first nuclear plant in the USSR.

This paper reports results from the study of mortality from malignancies of the hematopoietic and lymphatic system among personnel of the first nuclear reactor and processing plant in the USSR. Two registers have been set up. They include all personnel of the atomic reactor (register A) and of the radiochemical processing plant (register B).

[Malignant neoformations of the hematopoietic and lymphoid tissues in the personnel of the 1st plant of atomic industry].

Rates of mortality from hemopoietic and lymphoid malignancies for 1948-1987 were studied in male staff of industrial atomic reactors and radiochemical industry for irradiated uranium processing versus dose of external gamma radiation. An increase in mortality due to radiation--induced acute leukemia was registered in the radiochemical industry staff 5-10 years following the start of exposure and was associated with high dose of external radiation. The risk of acute leukemia for this period was 1.