Benzoyl peroxide stability in pharmaceutical gel preparations.

The storage stability of benzoyl peroxide in the presence of both individual and combined pharmaceutical gel ingredients was investigated. Benzoyl peroxide was quite unstable in the presence of nucleophilic agents and certain acidic substances. At both 30 and 40 degrees storage temperatures, benzoyl peroxide was destroyed rapidly (within 1 month) in the presence of ethanol and acidic chelating agents.

Functional and structural changes in isolated rabbit liver mitochondria induced by fluorodichloromethane.

Fluorodichloromethane caused changes in substrate respiration rates and also in adenosine diphosphate (ADP)-stimulated rates of oxidation of both succinate and glutamate. Active swelling of mitochondria also occurred, but only in the presence of magnesium ion. ADP/O ratios were not significantly affected by the fluorocarbon.

Measurement of plasma and tissue triiodothyronine concentration in the rat by radioimmunoassay.

This paper reports a radioimmunoassay method for triiodothyronine (T3) and the application of this assay to the study of plasma and tissue T3 concentration in the rat. Several antisera formed to a T3-bovine fibrogen complex in guinea pigs and T3-thyroglobulin complex in rabbits are shown to have low or no cross reactivity with T4, monoiodotyrosine, diiodotyrosine, tetraiodothyroacetic acid (TETRAC) and reverse T3. Cross reactivity with T3 derivatives, triiodothyroacetic acid (TRIAC), and triiodothyropropionic (TRIPROP) was variable, some antisera differentiating moderately well and others not at all.

The isolation and tentative identification of diacylglyceryl ethers from the walker 256 carcinoma of the rat and a human lymphosarcoma.

An unusual lipid was observed and subsequently isolated by thin-layer chromatography from the lipids of the Walker 256 carcinoma of the rat and a human lymphosarcoma. This lipid has been tentatively identified as a diacylgllyceryl ether by thinlayer chromatography, gas-liquid chromatography and infrared analysis.