30 m 5-yearly land cover maps of Qilian Mountain Area (QMA_LC30) from 1990 to 2020.

The Qilian Mountain Area (QMA) serves as a crucial ecological barrier and strategic water conservation zone in China. Recent years have seen heightened social attention to environmental issues within the QMA, underscoring the need for accurate and continuous land cover maps to support ecological monitoring, analysis, and forecasting. This paper presents the QMA_LC30 dataset, which includes 9 land cover categories and spans the period from 1990 to 2020, with updates every 5 years.

Fluoroindole chalcone analogues targeting the colchicine binding site of tubulin for colorectal oncotherapy.

Colorectal cancer (CRC) is a common malignancy of the gastrointestinal tract with high morbidity and mortality. Our previous studies have demonstrated that indole-chalcone-based compounds targeting tubulin displayed potential cytotoxicity to CRC cells. Herein, three new series of derivatives were systematically designed and synthesized to explore their structure-activity relationship (SAR) against CRC based on prior research.

Structure optimization of an F-indole-chalcone (FC116) on 4-methoxyphenyl group and therapeutic potential against colorectal cancers with low cytotoxicity.

Advanced metastatic colorectal cancers (CRCs) are regarded as a challenge in clinical cancer therapy. Our previous studies have demonstrated that a representative fluoro-substituted indole-chalcone (FC116), was obtained to display highly potent activity against CRC using multiple in vitro and in vivo mouse models by targeting microtubules. However, several problems, such as low dose tolerance and highly toxic to the brain and colon, low solubility unsuitable for intravenous (i.