The value of systemic immune inflammation index, white blood cell to platelet ratio, and homocysteine in predicting the instability of small saccular intracranial aneurysms.

Inflammation has a destructive effect on the homeostasis of the vascular wall, which is involved in the formation, growth, and rupture of human intracranial aneurysms (IAs) disease progression. However, inflammation-related markers have not been well studied in the risk stratification of unruptured IAs. The purpose of this study was to investigate the predictive value of serum inflammatory markers in the unstable progression of small saccular intracranial aneurysms (SIAs).

Accurate Prediction of the Magnetic Ordering Temperature of Ultralow-Temperature Magnetic Refrigerants.

Adiabatic demagnetization refrigeration is known to be the only cryogenic refrigeration technology that can achieve ultralow temperatures (≪1 K) at gravity-free conditions. The key indexes to evaluate the performance of magnetic refrigerants are their magnetic entropy changes (-Δ) and magnetic ordering temperature (). Although, based on the factors affecting the -Δ of magnetic refrigerants, one has been able to judge if a magnetic refrigerant has a large -Δ, how to accurately predict their remains a huge challenge due to the fact that the of magnetic refrigerants is related to not only magnetic exchange but also single-ion anisotropy and magnetic dipole interaction.

A root-knot nematode effector manipulates the rhizosphere microbiome for establishing parasitism relationship with hosts.

Introduction: Root-knot nematode (RKN; spp.) is one of the most infamous soilborne plant diseases, causing severe crop losses every year. Effector proteins secreted by RKNs play crucial roles during plant-nematode interaction.

The Spectral Response of the Dual Microdisk Resonator Based on BaTiO Resistive Random Access Memory.

With the resistive random access memory (ReRAM) devices based on the Al/BaTiO (BTO)/ITO structure fabricated at hand, by cross-analyzing the resistive memory characteristics in terms of various barium titanate (BTO) film thicknesses, it is found that the device with 60 nm thick BTO can be switched more than 425 times, while the corresponding SET/RESET voltage, the on-off ratio, and the retention time are -0.69 V/0.475 V, 10, and more than 10 seconds, respectively.

Gd(OH)F: A Promising Cryogenic Magnetic Refrigerant.

Magnetic refrigerants with a large magnetocaloric effect (MCE) in a wide temperature range and low magnetic ordering temperature () in the sub-kelvin temperature region are not only crucial for adiabatic demagnetization refrigeration but also open up a broader parameter space for the optimal design of adiabatic demagnetization refrigerators. However, such magnetic refrigerants are extremely rare because they require magnetic materials to simultaneously satisfy three conditions: low , weak magnetic interaction, and high magnetic density. Here, we report the syntheses, heat capacities, and magnetic properties of Gd(OH)F (: = 1, : ≈ 1.

A Gd-based borate-carbonate framework exhibiting a large magnetocaloric effect at a low magnetic field.

A 3D borate-carbonate framework, GdB(OH)CO (1), was synthesized. Magnetic study reveals that its MCE is up to 33.5 J kg K at 2 K and 2 T, due to the introduction of a long magnetic exchange path of Gd-O-B-O-Gd leading to 1 exhibiting weak magnetic interaction.

Magnetocaloric Effect and Thermal Conductivity of a 3D Coordination Polymer of [Gd(HCOO)(CO)].

A 3D coordination polymer, [Gd(HCOO)(CO)] was prepared. Its magnetocaloric effect (MCE) (32.7 J K kg at 2 K and 2 T) is significantly larger than that of commercial GdGaO (GGG) (14.

The emissions from co-firing of biomass and torrefied biomass with coal in a chain-grate steam boiler.

In this study, biomass of rice straw (RS) and wood (WD) and their torrefied biomass (RS and WD) were used as solid biofuel (SBF) for co-firing individually with coal in a commercial continuous chain-grate steam boiler system, which was conducted at fixed input rate of heating value of mixture of SBF and coal and at fixed airflow rate. The effects of key system parameters on the gaseous and particulate pollutions and ash were examined. These include SBF type and blending ratio (R) of biomass (i.

The lncRNA HULC functions as an oncogene by targeting ATG7 and ITGB1 in epithelial ovarian carcinoma.

Highly upregulated in liver cancer (HULC) is a long noncoding RNA (lncRNA), which has recently been identified as a key regulator in the progression of hepatocellular carcinoma, gliomas and gastric cancer. However, its role in epithelial ovarian carcinoma (EOC) remains unknown. In this study, HULC expression was examined in EOC, borderline and benign ovarian tumors, and normal ovarian tissues by RT-PCR.

The transcription factor FOXA1 induces epithelial ovarian cancer tumorigenesis and progression.

FOXA1 (forkhead box A1), a member of the FOXA transcription factor superfamily, plays an important role in tumor occurrence and development. However, the relationship between FOXA1 and ovarian cancer has not been reported. We examined normal ovarian tissue and ovarian cancer tissue and found increased FOXA1 expression in the cancer tissue.

E2F-1 targets miR-519d to regulate the expression of the ras homolog gene family member C.

E2F1 (E2F transcription factor 1) can act as a tumor suppressor or oncogene. We report the molecular mechanism of E2F1 in ovarian carcinoma tumorigenesis and progression. E2F1 expression levels in ovarian carcinoma tissue were examined by immunohistochemistry.

The role of metastasis-associated in colon cancer 1 (MACC1) in endometrial carcinoma tumorigenesis and progression.

Metastasis-associated in colon cancer-1 (MACC1), has recently been identified as a key regulator in the progression of many cancers. However, its role in endometrial carcinoma (EC) remains unknown. MACC1 expression was determined in EC and normal endometrial tissues by immunohistochemistry.

MicroRNA-93 Promotes Epithelial-Mesenchymal Transition of Endometrial Carcinoma Cells.

MicroRNA-93, derived from a paralog (miR-106b-25) of the miR-17-92 cluster, is involved in the tumorigenesis and progression of many cancers such as breast, colorectal, hepatocellular, lung, ovarian, and pancreatic cancer. However, the role of miR-93 in endometrial carcinoma and the potential molecular mechanisms involved remain unknown. Our results showed that miR-93 was overexpressed in endometrial carcinoma tissues than normal endometrial tissues.

Role of glycogen synthase kinase-3β inhibitor AZD1080 in ovarian cancer.

Background: Glycogen synthase kinase-3β (GSK-3β) is a multifunctional serine/threonine kinase that plays an important role in cancer tumorigenesis and progression. We investigated the role of the GSK-3β inhibitor AZD1080 in ovarian cancer cell lines.

Methods: A2780 and OVCAR3 ovarian cancer cell lines were exposed to AZD1080, after which cell proliferation, cell cycle, invasion, and migration assays were performed.

The role of glycogen synthase kinase-3β (GSK-3β) in endometrial carcinoma: A carcinogenesis, progression, prognosis, and target therapy marker.

Purpose: Glycogen synthase kinase-3β (GSK-3β) is a serine/threonine kinase involved in cancer development. Herein, we demonstrated the role of GSK-3β in endometrial cancer (EC) and identified new therapeutic targets.

Results: GSK-3β was overexpressed in EC tissues, and was positively correlated with International Federation of Gynecology and Obstetrics (FIGO) staging, dedifferentiation, and myometrial infiltration depth.

The correlation between microRNA490-3p and TGFα in endometrial carcinoma tumorigenesis and progression.

MicroRNAs (miRNAs) are small non-coding RNAs that negatively regulate the translation of messenger RNAs by binding their 3'-untranslated region (3' UTR). MiR-490-3p has been reported to be a suppressor in various human cancers; however, little is known about the biological functions of miR-490-3p in endometrial cancer (EC). In our study, we found that MiR-490-3p mRNA expression was significantly lower in ECs than in normal endometrial tissues.

MicroRNA-505 functions as a tumor suppressor in endometrial cancer by targeting TGF-α.

Background: Endometrial carcinoma (EC) is one of the most lethal gynecologic cancers. Patients frequently have regional or distant metastasis at diagnosis. MicroRNAs are small non-coding RNAs that participate in numerous biological processes.

MicroRNA-372 inhibits endometrial carcinoma development by targeting the expression of the Ras homolog gene family member C (RhoC).

Here we explore the role of microRNA-372 (miR-372) in tumorigenesis and development of endometrial adenocarcinoma (EC) and analyze the underlying mechanism. We found that miR-372 expression is much lower in EC than normal endometrial specimens. Cell function experiments demonstrated that miR-372 overexpression suppressed cell proliferation, migration, and invasion, and led to a G1 phase arrest and promoted the apoptosis of endometrial carcinoma cells in vitro.

MicroRNA-186 induces sensitivity of ovarian cancer cells to paclitaxel and cisplatin by targeting ABCB1.

Background: Recent studies have shown that microRNAs may regulate the ABCB1 gene (ATP-binding cassette, sub-family B [MDR/TAP], member 1). Computational programs have predicted that the 3'-untranslated region (3'-UTR) of ABCB1 contains a potential miRNA-binding site for miR-186. Here, we investigated the role of miR-186 in sensitizing ovarian cancer cells to paclitaxel and cisplatin.