Severe Symptomatic Aortic Stenosis in an Octogenarian with Congenitally Corrected Transposition of the Great Arteries.

• ccTGA accounts for 0.5%-1.4% of patients with congenital heart disease.

Comparison of social isolation in autistic children and adolescents according to age, marital status and number of siblings.

Background: Children and adolescents with autism spectrum disorder (ASD) have difficulties that limit their opportunities to interact with peers and family members. These behaviors can lead to social exclusion, and consequently social isolation. The aim was to compare social isolation of children and adolescents with ASD according to age, marital status, and number of siblings.

Utility for Clinical Practice of a Bifactor ADHD Model in an Elementary School Population in Mexico.

We assessed the appropriateness of the bifactor model for a Mexican ADHD symptom questionnaire (BMQ-ADHD) applied to parents and teachers of elementary school children. With a sample of 765 reports of children's behavior (48.7% with ADHD A1 criteria, 42.

2D SLAM Algorithms Characterization, Calibration, and Comparison Considering Pose Error, Map Accuracy as Well as CPU and Memory Usage.

The present work proposes a method to characterize, calibrate, and compare, any 2D SLAM algorithm, providing strong statistical evidence, based on descriptive and inferential statistics to bring confidence levels about overall behavior of the algorithms and their comparisons. This work focuses on characterize, calibrate, and compare Cartographer, Gmapping, HECTOR-SLAM, KARTO-SLAM, and RTAB-Map SLAM algorithms. There were four metrics in place: pose error, map accuracy, CPU usage, and memory usage; from these four metrics, to characterize them, Plackett-Burman and factorial experiments were performed, and enhancement after characterization and calibration was granted using hypothesis tests, in addition to the central limit theorem.

A phase 2 study for evaluating doxycycline 50 mg once daily and 100 mg once daily as preemptive treatment for skin toxicity in patients with metastatic colorectal cancer treated with an anti-EGFR and chemotherapy.

Purpose: To assess the efficacy, safety, and quality-of-life outcomes of doxycycline 50 or 100 mg once daily in the prevention of skin toxicity in patients undergoing chemotherapy plus anti-EGFR therapy as first-line treatment of metastatic colorectal cancer (mCRC).

Methods: Phase II, multicenter, single-arm, exploratory study was conducted in 7 Spanish hospitals. The primary study outcome was the incidence of ≥ grade 2 skin toxicities during the 6-week skin treatment period.

Filter bank approach for enhancement of supervised Canonical Correlation Analysis methods for SSVEP-based BCI spellers.

Canonical correlation analysis (CCA) is one of the most used algorithms in the steady-state visual evoked potentials (SSVEP)-based brain-computer interface (BCI) systems due to its simplicity, efficiency, and robustness. Researchers have proposed modifications to CCA to improve its speed, allowing high-speed spelling and thus a more natural communication. In this work, we combine two approaches, the filter-bank (FB) approach to extract more information from the harmonics, and a range of different supervised methods which optimize the reference signals to improve the SSVEP detection.

The Aβ(1-38) peptide is a negative regulator of the Aβ(1-42) peptide implicated in Alzheimer disease progression.

The pool of β-Amyloid (Aβ) length variants detected in preclinical and clinical Alzheimer disease (AD) samples suggests a diversity of roles for Aβ peptides. We examined how a naturally occurring variant, e.g.

The Effects of Exposure to Recent Autobiographical Events on Declarative Memory in Amnestic Mild Cognitive Impairment: A Preliminary Pilot Study.

Background: Individuals with amnestic Mild Cognitive Impairment (aMCI) are at heightened risk of developing Alzheimer's dementia. In recent years, much attention has been given to the search for new interventions to slow down the progression of cognitive decline of these patients. Wearable digital camera devices are one form of new technology that captures images of one's life events, so they constitute a promising method to be used as a means to stimulate recent autobiographical memory.

SEOM clinical guidelines to primary prevention of cancer (2018).

Cancer is the leading social and healthcare problem of the twenty-first century. The aim of primary prevention is to decrease the incidence of cancer by avoiding the known causes and risk factors. Nevertheless, it has been estimated that cancer diagnoses could be halved through primary prevention measures.

Six-Year Prospective Outcomes of Primary Breast Augmentation With Nano Surface Implants.

Background: Motiva Implants (Establishment Labs Holdings Inc.) are a novel family of silicone breast implants using cutting-edge technologies engineered to optimize aesthetic and safety outcomes.

Objectives: The authors sought to prospectively evaluate the safety and effectiveness of SmoothSilk/SilkSurface Motiva Implants over long-term follow-up.

Hierarchical Spectral Consensus Clustering for Group Analysis of Functional Brain Networks.

A central question in cognitive neuroscience is how cognitive functions depend on the integration of specialized widely distributed brain regions. In recent years, graph theoretical methods have been used to characterize the structure of the brain functional connectivity. In order to understand the organization of functional connectivity networks, it is important to determine the community structure underlying these complex networks.

Use of antiplatelet drugs after cardiac operations.

Unfortunately, venous bypass grafts still have a prominent role in operative coronary revascularization (coronary artery bypass graft [CABG]). Venous grafts develop pathologically occlusive disease that limits the effectiveness of CABG, and antiplatelet drugs following operation may limit this problem. The types and indications of antiplatelet drugs following CABG generate some controversy in the recent literature.

Identification of patients with postoperative complications who are at risk for failure to rescue.

Importance: A minority of patients who experience postoperative complications die (failure to rescue). Understanding the preoperative factors that lead to failure to rescue helps surgeons predict and avoid operative mortality.

Objective: To provide a mechanism for identifying a high-risk group of patients with postoperative complications who are at a substantially increased risk for failure to rescue.

Second primary malignancies in patients with neuroendocrine tumors.

Purpose: An association between neuroendocrine tumors (NETs) and second primary malignancies (SPMs) has been reported. We have examined the incidence and etiology of SPMs in patients with NETs included in the Neuroendocrine Tumor Association of Andalusia (ATNEA) Registry.

Methods: Data on 111 patients were collected.

A combination of physical and cognitive exercise improves reaction time in persons 61-84 years old.

We have compared the effects of different 12-week exercise programs on simple and choice reaction and movement times in persons 61 to 84 years old. One hundred thirty-eight volunteers were randomized to either a control group, a two-day exercise group (two 60-min sessions a week of aerobic exercises), or a two-day physical plus cognitive exercise group (two 60-min sessions a week of aerobic and cognitive exercises). At follow-up, the aerobic and cognitive exercise program was found to have resulted in significant positive effects.

[Enteroparasitism, hygiene and environmental sanitation in under-aged from six indigenous communities. Cali-Colombia].

Objective: Determine the prevalence of intestinal parasitism and associated factors in indigenous children between 5 and 14 years, living in the city of Cali, Colombia.

Methodology: 63 children aged 5 to 14 were included. At least two fecal samples were taken to which two different tests were applied, first one directly and the other one for concentration: Ziehl-Neelsen modified and Kato Katz.

Intestinal parasitism prevalence amongst children from six indigenous communities residing in Cali, Colombia.

Objective: Establishing the prevalence of intestinal parasitism in children aged 5 to 14 years of age from six indigenous communities residing in the city of Cali.

Methodology: A cross-sectional, descriptive epidemiological study was carried out in six indigenous communities residing in the city of Cali; it consisted of making a direct serial and concentration coproparasitological examination of a randomly selected sample of fifty-seven 5 to 14 year-old children.

Results: Of the 57 samples obtained, 84 % of the children were infected with parasites; protozoa (98 %) predominated over helminths (16.

A weighted small world network measure for assessing functional connectivity.

There is a growing need to develop measures that can characterize complex patterns of functional connectivity among brain regions. Graph theoretic measures have emerged as an important way to characterize the multivariate connectivity between nodes in a network, which have been successfully applied to neurophysiologic activity. In this paper, we propose a new small-world measure based on advances in both the bivariate measures underlying the graph theoretic approach, as well as in the definition of the measure for weighted graphs.

Coauthorship and institutional collaborations on cost-effectiveness analyses: a systematic network analysis.

Background: Cost-Effectiveness Analysis (CEA) has been promoted as an important research methodology for determining the efficiency of healthcare technology and guiding medical decision-making. Our aim was to characterize the collaborative patterns of CEA conducted over the past two decades in Spain.

Methods And Findings: A systematic analysis was carried out with the information obtained through an updated comprehensive literature review and from reports of health technology assessment agencies.

Molecular method for the characterization of Coxiella burnetii from clinical and environmental samples: variability of genotypes in Spain.

Background: Coxiella burnetii is a highly clonal microorganism which is difficult to culture, requiring BSL3 conditions for its propagation. This leads to a scarce availability of isolates worldwide. On the other hand, published methods of characterization have delineated up to 8 different genomic groups and 36 genotypes.

X-linked inhibitor of apoptosis protein-mediated attenuation of apoptosis, using a novel cardiac-enhanced adeno-associated viral vector.

Successful amelioration of cardiac dysfunction and heart failure through gene therapy approaches will require a transgene effective at attenuating myocardial injury, and subsequent remodeling, using an efficient and safe delivery vehicle. Our laboratory has established a well-curated, high-quality repository of human myocardial tissues that we use as a discovery engine to identify putative therapeutic transgene targets, as well as to better understand the molecular basis of human heart failure. By using this rare resource we were able to examine age- and sex-matched left ventricular samples from (1) end-stage failing human hearts and (2) nonfailing human hearts and were able to identify the X-linked inhibitor of apoptosis protein (XIAP) as a novel target for treating cardiac dysfunction.