Publications by authors named "Bolan Zhang"
Advanced glycation end products (AGE), a diverse array of molecules generated through non-enzymatic glycosylation, in conjunction with the receptor of advanced glycation end products (RAGE), play a crucial role in the pathogenesis of diabetes and its associated complications. Recent studies have revealed that the AGE-RAGE axis potentially accelerated the progression of cardiovascular diseases, including heart failure, atherosclerosis, myocarditis, pulmonary hypertension, hypertension, arrhythmia, and other related conditions. The AGE-RAGE axis is intricately involved in the initiation and progression of cardiovascular diseases, independently of its engagement in diabetes.
View Article and Find Full Text PDFBackground: There are no large randomized trials of the effect of folic acid dosing regimens on blood folate and homocysteine concentrations.
Objective: We aimed to evaluate the changes in folate and homocysteine concentrations in response to different folic acid doses and to withdrawal in young women not exposed to other sources of folic acid.
Design: Women (n = 1108) were randomly assigned to 1 of 6 intervention groups for which daily intakes of folic acid for 6 mo were 100 microg 1 time/d, 25 microg 4 times/d, 400 microg 1 time/d, 100 microg 4 times/d, 4000 microg 1 time/d, or 4000 microg 1 time/wk.
Objective: To study the association between transforming growth factor alpha gene (TGFalpha) TaqI variant and nonsyndromic cleft lip with or without cleft palate (nsCL/P) in Chinese population, and the interaction with parental smoking.
Methods: TGFalpha TaqI variant was detected using RFLP-PCR for DNA samples of the 170 triads with nsCL/P affected child. We performed the transmission/disequilibrium test (TDT) and the family-based association study (FBAT) to test the associations between this variant and risk of nsCL/P.
[Study on the association between transforming growth factor alpha gene TaqI variant and cleft lip with or without cleft palate].
Zhonghua Liu Xing Bing Xue Za Zhi
March 2006
Objective: To study the association between transforming growth factor alpha gene (TGFalpha) TaqI variant and nonsyndromic cleft lip with or without cleft palate (nsCL/P) in Chinese population.
Methods: TGFalpha TaqI variant was detected using polymerase chain reaction-restriction fragment length polymorphism for DNA samples of the 149 triads with nsCL/P affected child. We performed the Transmission/disequilibrium test and the family-based association study (FBAT) to identify the associations between this variant and risk of nsCL/P.
Objective: To study the association between reduced folate carrier gene (RFC1) polymorphism and congenital heart defects (CHD) as well as cleft lip with or without cleft palate (CLP) and to provide epidemiological evidence on genetic markers of CHD and CLP.
Methods: RFC1 (A80G) genotype was detected using RFLP-PCR for blood DNA of the 67 triads with nonsyndromic CHD-affected child, the 82 triads with child-affected cleft lip with or without CLP and the 100 control families without child-affected birth defects. We performed a family-based association test and analyzed the interaction between RFC1 A80G genotype and maternal periconceptional supplementation of folic acid.
[Study on reduced folate carrier gene (RFC1) polymorphism in the southern and northern Chinese population].
Zhonghua Liu Xing Bing Xue Za Zhi
June 2004
Objective: To describe the distribution of reduced folate carrier gene (RFC1)genotype and allele frequency between southern and northern, female and male Chinese population.
Method: RFC1 (A80G) genotype was detected, using polymerase chain reaction-restriction fragment length polymorphism (RFLP-PCR) on 720 blood spot DNA from the normal subjects.
Results: The frequencies of the northern population with AA, GG and GA genotypes were 22.
[The epidemiology of neural tube defects in high-prevalence and low-prevalence areas of China].
Zhonghua Liu Xing Bing Xue Za Zhi
June 2003
Article Synopsis
- The study examines the prevalence of neural tube defects (NTDs) in high-prevalence regions (North) versus low-prevalence regions (South) of China, highlighting significant differences in rates and types of defects.
- Analysis of data from a cooperative project revealed that the North had an overall NTD prevalence of 5.57 per 1,000 births compared to 0.88 in the South, with specific defects like anencephaly and spina bifida being much more common in the North.
- Urban versus rural comparisons indicated that rural areas in both regions had higher rates of NTDs, particularly in the North, and seasonal variations in the occurrence of certain defects were noted as well.
[Variation of plasma folate levels in adults between some areas and different seasons in China].
Zhonghua Yu Fang Yi Xue Za Zhi
September 2002
Objective: To describe the distribution of plasma folate concentrations and prevalence of folate deficiency in adults aged 35 to 64 years in some areas and different seasons in China.
Methods: Study subjects were sampled from the representative rural and urban areas in the south and north of China aged 35 to 64 years totaling 2 545, and their plasma folate concentrations were determined and analyzed.
Results: Plasma concentrations of folate in the southern population were significantly higher (16.