[TREATMENT OF SHORT STATURE PATIENTS WITH NOPMAL GROWTH HORMONE SECRETION OF HYPOPHIS].

The article presents the treatment outcome in 86 children with short stature associated with different endocrine pathology and saved growth hormone secretion (congenital adrenal hyperplasia chondrodystrophy, Turner syndrome, idiopathic short stature, syndrome biologically inactive growth hormone and other genetically determined pathology). This study extends prior knowledge about the outcomes of the treatment with recombinant growth hormone and luteinizing hormone--releasing hormone analogue (alone or in combination) in short patients with poor prognosis of final height.

[Gamma-aminobutyric acid content and activity of the enzyme synthesizing it in blood plasma of children exposed to ionizing radiation as a result of the accident at the Chernobyl nuclear power plant].

Marked individual fluctuations in blood levels of GABA and GDC revealed in 35 to 50% of adolescents exposed to ionizing radiation several years before indicate the presence of an imbalance in the GABA-ergic system. These children (with GABA-ergic system disturbances) represent a group at risk of developing remote effects of radiation exposure presenting as disturbed rhythms and terms of sexual maturation, of growth, thyroid and adrenal abnormalities, and they should be regularly checked up.

[Effect of 131I incorporation on the status of the reproductive system in male rats and the dose-dependent effect].

Radioactive 131I was injected in single doses 9.25, 37, and 92.5 kBq to prepubertal (30-day-old) male rats.

[Morphofunctional characteristics of malignant thyroid gland tumors in children from various regions of the Ukraine, who have been victims of of the Chernobyl nuclear power plant accident].

Thyroid cancers in children from the affected areas of Ukraine were investigated by means of light (33 cases) and electron (20 cases) microscopy. Statistical data from 25 regions of Ukraine have been analyzed concerning thyroid cancer in patients aged up to 18 years for the period 1981-1990. There is an increase in the number of thyroid cancers in the children of Ukraine from 0.

[Characteristics of prolactin secretion in patients with different types of gonadal dysgenesis].

A study was made of the level of prolactin in the blood plasma of 55 patients aged 16 to 23 with different types of gonad dysgenesia. It was shown for the first time that in most of the patients with gonad dysgenesia disregarding pathology type the level of prolactin did not differ from that in the follicular phase of the menstrual cycle of healthy girls, and was significantly decreased as compared to the level of this hormone in the luteal phase. Estrogen therapy caused a considerable rise of the prolactin level in all the examines.

[Comparative study of the efficacy of different methods of treating patients with the Shereshevskii-Turner syndrome].

A comparative study of the effect of anabolic steroids and estrogens on the growth and sex development of patients with Shereshevskii-Turner syndrome (STS) was made for a choice of the most effective therapeutic modality. The use of anabolic steroids to stimulate the growth of patients with STS was shown to be ineffective. The most effective was the use of the combination of anabolic steroids and estrogens at low doses starting from the age of 11-13 resulting in satisfactory development of secondary characteristics without growth inhibition.

[Experience with the treatment of children with diabetes mellitus using allo- and xenografts of cultures of pancreatic islet cells].

The paper is concerned with the study of the results of allo- and xenotransplantation of pancreatic islet cell culture to 44 children aged 1.5 to 15 suffering from a severe form of insulin dependent diabetes mellitus. An impossibility to achieve stable compensation of disease with routine therapy and complications of diabetes mellitus were the main indications for transplantation.