Apoptosis of leukocytes as a marker of neutrophil-endotheliocyte interaction in coronary heart disease.

We studied the mechanism of interaction of peripheral blood neutrophils with endothelial cells (expression of cell adhesion molecules and production of NO) and the role of neutrophil apoptosis in the development of endothelial dysfunction. The effects of mitochondrial dysfunction of neutrophils on the development of apoptosis of these cells after their interaction with endothelial cells were analyzed.

[Effects of biological factors on isoantigens of ABO system].

The paper provides data about alterations of antigen ABO system in pathological states. These changes result from emergence and following action of the enzyme neuromidase to form latent determinant T.

[Morphological study of human hair infected with Microsporum canis].

Some aspects in forensic medical examination of hairs damaged by Microsporum canis are discussed. The data of microscopic, fluorescent, and serological studies of damaged hairs and methods for their examination are presented.

[A method for group identification of hair infected with Microsporum].

A method for identifying the group appurtenance of biological objects from subjects suffering from various diseases is developed. The method can be used in examination of putrefactive objects (blood, secretions, hair, etc.) and in cases when the group appurtenance cannot be identified by other methods.

[Induction of mutations in Streptomyces antibioticus].

Mutagenic action of UV-light, nitrosoguanidine and nitrosomethylbiuret was studied in Streptomyces antibioticus VNIIA 1607. Nitrosomethylbiuret appeared to be most effective inducer of auxotrophic mutations (mutation frequency reached 15%). By means of hybridological analysis, it was shown that heterokaryons predominated in the progeny of mixed cultures of multiply marked strains.

[Inhibition of oleandomycin biosynthesis by glucose].

The results of the study on the effect of glucose and various carbohydrates on biosynthesis of oleandomycin by Streptomyces antibioticus are presented. It was found that glucose added at the beginning or by the 48th hour of the fermentation process on the complex medium inhibited oleandomycin biosynthesis. To investigate the mechanism of the glucose effect, a fermentation medium was developed.

[Diagnostic value of electrocardiographic criteria of left ventricular hypertrophy in hypertension in a population study].

The correlation between the diagnosis by the criteria of the Minnesota code and the known indices of left ventricular hypertrophy (LVH) (RAVL greater than or equal to 7 mm, Rv5,6 + Sv1,2 greater than greater than 35 mm, Rv6 greater than Rv4 Sv2 greater than 24 mm) in 12 standard leads and the roentgenocardiometric data has been analyzed. 156 males (35-54 years of age) and 175 females (30-52 years of age) suffering from first and second stage of essential hypertension as well as 60 male and 30 female controls from the staff population of the Likhachev Plant have been studied. The study has shown that sensitivity of the above ECG criteria for LVH, diagnosed by roentgenocardiometry, is higher in males than in females, their specificity being higher in females.

[Developmental cycle and the cytomorphological characteristics of the oleandomycin producer Streptomyces antibioticus].

The developmental cycle and cytomorphological features of the industrial strain OL-1 and its variant 0968 of the oleandomycin-producing organism were studied. Variant 0968 was obtained as a result of exposure of the spores of strain OL-1 to UV light. When grown under submerged conditions in flasks with the rich medium, the strains were characterized by a complete developmental cycle consisting of three generations of the hyphae.

[Use of acridine yperite in the selection of Act. nodosus, a producer of amphotericin B].

The effect of acridine-yperite (AY) on Act. nodosus LIA 0861 at various physiological stages of development was studied. It was shown that both the spores and the germs were sensitive to AY.

[Myocardial contraction in ischemic heart disease].

The indices of contractility of the left ventricular myocardium were studied by means of ventriculography and catheterization in 84 patients with ischemic heart disease according to the extent of damage to the coronary arteries and the course of the disease. Changes in the coronary arteries were encountered twice as frequently among patients with postinfarction cardiosclerosis as among patients with angina pectoris and no history of infarction. The main cause of disorders of myocardial contractility in patients with ischemic heart disease is post-infarction cardiosclerosis (56% of cases).

[Production in an Actinomyces levoris culture under the action of an actinophage specific to it of variants with stable preservation of its resistance to the phage].

Act. levoris 28, an organism producing levorin was treated with an actinophage virulent to it. Variants of the organism were isolated from the secondary growth of the culture.