Active tuning of dispersive waves in Kerr soliton combs.

Kerr soliton combs operate in the anomalous group-velocity dispersion regime through the excitation of dissipative solitons. The generated bandwidth is largely dependent on the cavity dispersion, with higher-order dispersion contributing to dispersive-wave (DW) generation that allows for power enhancement of the comb lines at the wings of the spectrum. However, the spectral position of the DW is highly sensitive to the overall cavity dispersion, and the inevitable dimension variations that occur during the fabrication process result in deviations in the DW emission wavelength.

Synchronization of nonsolitonic Kerr combs.

Synchronization is a ubiquitous phenomenon in nature that manifests as the spectral or temporal locking of coupled nonlinear oscillators. In the field of photonics, synchronization has been implemented in various laser and oscillator systems, enabling applications including coherent beam combining and high-precision pump-probe measurements. Recent experiments have also shown time-domain synchronization of Kerr frequency combs via coupling of two separate oscillators operating in the dissipative soliton [i.

Demonstration of chip-based coupled degenerate optical parametric oscillators for realizing a nanophotonic spin-glass.

The need for solving optimization problems is prevalent in various physical applications, including neuroscience, network design, biological systems, socio-economics, and chemical reactions. Many of these are classified as non-deterministic polynomial-time hard and thus become intractable to solve as the system scales to a large number of elements. Recent research advances in photonics have sparked interest in using a network of coupled degenerate optical parametric oscillators (DOPOs) to effectively find the ground state of the Ising Hamiltonian, which can be used to solve other combinatorial optimization problems through polynomial-time mapping.

Turn-key, high-efficiency Kerr comb source.

We demonstrate an approach for automated Kerr comb generation in the normal group-velocity dispersion (GVD) regime. Using a coupled-ring geometry in silicon nitride, we precisely control the wavelength location and splitting strength of avoided mode crossings to generate low-noise frequency combs with pump-to-comb conversion efficiencies of up to 41%, which is the highest reported to date for normal-GVD Kerr combs. Our technique enables on-demand generation of a high-power comb source for applications such as wavelength-division multiplexing in optical communications.

Molecular design, synthesis, and hypoglycemic and hypolipidemic activities of novel pyrimidine derivatives having thiazolidinedione.

We previously reported the synthesis and biological activity of novel substituted pyridines and purines having thiazolidinedione with hypoglycemic and hypolipidemic activities. We now report the synthesis and antidiabetic activity of novel substituted pyrimidines having thiazolidinedione moiety. These compounds (entry No.

Synthesis and biological activity of novel substituted pyridines and purines containing 2,4-thiazolidinedione.

A series of substituted pyridines and purines containing 2,4-thiazolidinedione were designed and synthesized from their corresponding pyridines and purines. These synthesized compounds (entry no. 6a-d, 12a-e, 18a-d, 23a-c) were evaluated for their effect on triglyceride accumulation in 3T3-L1 cells in vitro and their hypoglycemic and hypolipidemic activity in the genetically diabetic KKA(y) mice in vivo.

Synthesis and antihyperglycemic activity of erythrose, ribose and substituted pyrrolidine containing thiazolidinedione derivatives.

A series of erythrose, ribose, and substituted pyrrolidine containing 2,4-thiazolidinediones were synthesized. Among them, thirteen unsaturated thiazolidinediones, six saturated thiazolidinediones and two unsaturated malonates were evaluated for their ability to enhance glucose utilization in cultured L6 myocytes. On the basis of the in vitro activity, 5-[4-[2-(1-benzyl-3,4-bis-benzyloxypyrrolidin-2-yl)ethoxy]benzylidene]thiazolidine-2,4-dione 24b was selected as the candidate for further pharmacological studies.