[Skin reactivity in the histamine-equivalent skin test in hypersensitivity to grass pollen].

Introduction: Skin prick-test has been accepted as one of diagnostic criteria for atopic diseases. In accordance with the recommendations of the EAACI (European Academy of Allergy and Clinical Immunology), the Subcommittee for skin testing, allergen specific skin prick-test should be estimated in relation to positive control (histamine hydrochloride in the HEP system/histamine equivalent prick/) [1-4]. The purpose of this study was to establish a recording system of skin sensitivity to allergen by using HEP method in our patients.

[Total allergen-specific IgE antibodies in the serum and skin reactivity induced by a mixture of pollens in allergic individuals].

Skin puncture test is fast and precise method for revealing IgE-mediated allergen hypersensitivity. In the diagnosis of pollinosis and other atrophic diseases, expensive tests for revealing the allergen-specific IgE antibodies in the serum are frequently inaccessible. The subject of our investigation was how and if the skin test with mixture of pollen could replace the expensive in-vitro method in diagnostic procedure.

[Atopy and drug allergy].

Unlabelled: The aim of our study is to show possible correlation between atopy and drug allergy, and the clinical manifestations of drug allergy that may have predictive value. There were 150 patients with positive history of drug allergy, ages 18-73 years. Cutaneous anr/or dose provocative testing was done, depending on the drug.

[Significance of monitoring histamine serum levels, cryoglobulins and complement titers during cold tests in patients with cold allergy and Raynaud's phenomenon].

The aim of our investigations is to evaluate blood histamine, complement titer and cryoglobulins before and after cold stimulation (extremity water immersion test) in patients with cold urticaria and Raynaud phenomenon. In our investigations patients were put into five groups according to the following diagnoses: cold urticaria (40 patients), chronic urticaria (15 patients), Urticaria-Vasculitis Syndrome (15 patients), Raynauds Disease (16 patients), and Raynauds phenomenon (15 patients). The investigations demonstrated that the test was always positive in cold urticaria and that a high percentage of patients had a rise in blood histamine.

[Laboratory study of patients with endemic nephropathy].

The introduction deals with the main characteristics of two representatives of high risk pregnancies: diabetes mellitus and EPH gestoses. Particular interest was shown in risks that may occur in pregnant diabetics, with which they must be acquainted. Some theories are given on the pathogenesis of EPH gestoses.

[Proteinuria in dermal vasculitis (incidence, degree and possible mechanisms of onset)].

The paper comprises 63 patients with diagnosed vasculitis of the skin who had abnormal findings in the urine. Thirteen of these patients had positive skin findings and abnormal findings in the urine, with concomitant attacks of dyspnea as seen in bronchial asthma. These patients account for 20% of the entire group, while there was an incidence of 37% of systemic manifestations.

[Effect of ranitidine on the pharmacokinetics of theophylline in patients with obstructive pulmonary disease].

Investigations were performed on 20 patients with mild and moderately severe forms of bronchiale asthma or chronic obstructive bronchitis. Theophylline for oral use (sustained release form) and Ranitidine (second generation H2-blocker) were used in the first group of patients (7 females and 3 males, average age 37.9).

[The effect of ranitidine on theophylline pharmacokinetics in patients with obstructive lung disease].

The study was performed in 20 patients with mild and moderately severe forms of bronchial asthma or chronic obstructive bronchitis. Theophylline for oral use (sustained release form) and ranitidine was used in the first group of patients (7 females and 3 males, mean years of age 37.9).