Identifification of a novel LDLR-RET Fusion in Lung Adenocarcinoma.

Background: REarranged during Transfection (RET) gene fusion is one of the common oncogenic variants detectable in non-small cell lung cancer (NSCLC). The feature of most oncogenic RET gene fusion cases is that RET tyrosine kinase domain is retained in fusions and the partner gene includes a coiled-coil or LIS1 homology domain. However, only a few studies reported about the exceptional form of RET fusion in NSCLC so far.

Crystalline Behavior of Paraffin Wax.

Paraffin wax deposition has long been a vexing problem in industry. Especially, in offshore oil production, paraffin wax deposits and clogs pipes and containers because of low temperature, causing severe economic loss. It has been known that the crystallization of n-alkanes mainly causes the deposition of paraffin wax, which is necessary to understand the mechanism of the crystallization behavior of paraffin wax.

Polymer pattern-induced self-assembly of inorganic nanoparticles.

Functional assemblies of inorganic nanoparticles (NPs) are widely studied owing to their collective electromagnetic properties and various application from nanodrugs and bioimaging. In most cases, the superstructures of NPs are prepared with the assistance of templates or external fields. Therefore, how to prepare the functional assemblies of NPs more simply remains a challenge.

Downregulation of SIRT6 is associated with poor prognosis in patients with non-small cell lung cancer.

Objective To explore the prognostic significance of nicotinamide adenine dinucleotide (NAD)-dependent protein deacetylase sirtuin-6 (SIRT6), encoded by the sirtuin 6 ( SIRT6) gene, in a population of Chinese Han patients with non-small cell lung cancer (NSCLC). Methods Cancer tissues and normal lung tissues (>5 cm adjacent to cancer tissue) were collected from Chinese Han patients with NSCLC. Expression levels of SIRT6 and histone H3-acetyl K56 ( H3K56), in cancer and normal lung tissues from patients with NSCLC, were detected by reverse-transcription polymerase chain reaction, Western blot and immunohistochemistry.