Publications by authors named "Bojidar M Kandar"
Acute radiation syndrome (ARS) is a major cause of lethality following radiation disasters. A TLR5 agonist, entolimod, is among the most powerful experimental radiation countermeasures and shows efficacy in rodents and non-human primates as a prophylactic (radioprotection) and treatment (radiomitigation) modality. While the prophylactic activity of entolimod has been connected to the suppression of radiation-induced apoptosis, the mechanism by which entolimod functions as a radiomitigator remains poorly understood.
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- * The study explores the use of entolimod, a TLR5 agonist, and demonstrates that it protects liver and lung tissues from TNF and LPS-induced toxicity in mouse models, reducing indicators of tissue damage.
- * Entolimod's protective effects rely on TLR5 expression in non-hematopoietic cells and do not interfere with TNF's anticancer effectiveness, suggesting TLR5 agonists could enhance cancer treatment safety by minimizing toxicity risks.