Utility of iodine overlay technique and virtual unenhanced images for the characterization of renal masses by dual-energy CT.

Objective: The objective of our study was to assess the utility of dual-energy CT for characterizing renal masses using iodine overlay techniques and virtual unenhanced images and to measure the potential radiation dose reduction for two-phase kidney CT compared with a standard three-phase protocol.

Materials And Methods: Sixty patients with suspected renal masses underwent dual-energy CT including true unenhanced, dual-energy corticomedullary, and dual-energy late nephrographic phase imaging. Iodine overlay and virtual unenhanced images were derived from the corticomedullary and late nephrographic phases, respectively.

MRI and its role in the evaluation and surgical decision making in patients with challenging IPP presentations: descriptions of MRI findings and algorithm for patient management.

Unlabelled: Study Type - Diagnostic (case series) Level of Evidence 4 What's known on the subject? and What does the study add? It is known that magnetic resonance imaging (MRI) is safe and effective for imaging patients with inflatable penile prostheses (IPPs). Previous series have reported results of MRI for imaging series of patients with IPPs. The impact on management in particular with regard to salvage procedures is not well defined.

Imaging evaluation of amyloidosis of the urinary tract and retroperitoneum.

Amyloidosis is a heterogeneous group of disorders and may be classified as systemic or localized on the basis of the distribution of amyloid deposition. Infrequently, the urinary tract and supporting retroperitoneum may be involved, and the imaging findings are nonspecific and diverse. Localized amyloidosis usually involves the bladder and often mimics malignancy.

Assessment of renal lesions with blood oxygenation level-dependent MRI at 3 T: preliminary experience.

Objective: The purpose of this article is to prospectively determine the feasibility of using blood oxygenation level-dependent (BOLD) MRI at 3 T in differentiating various renal lesions.

Subjects And Methods: Seventy-one patients (mean age, 53.8 years; range, 22-80 years) underwent kidney MRI, including BOLD MRI at 3 T.

De Novo Superinfection of Hepatitis B Virus in an Anti-HBs Positive Patient with Recurrent Hepatitis C Following Liver Transplantation.

A 60-year-old woman with end stage liver cirrhosis caused by genotype 2 hepatitis C virus (HCV) infection received an orthotopic liver transplantation (OLT). The patient was negative for the hepatitis B surface antigen (HBsAg) and positive for the anti-hepatitis B surface antibody (anti-HBs) prior to and one and a half months following the OLT. Due to reactivation of hepatitis C, treatment with interferon-alpha and Ribavirin started two months following the OLT and resulted in a sustained virological response.

MR staging accuracy for endometrial cancer based on the new FIGO stage.

Background: Magnetic resonance imaging (MRI) has been frequently used to determine a preoperative treatment plan for gynecologic cancers. However, the MR accuracy for staging an endometrial cancer is not satisfactory based on the old FIGO staging system.

Purpose: To evaluate MR accuracy for staging endometrial cancer using the new FIGO staging system.

Single-molecule atomic force microscopy force spectroscopy study of Aβ-40 interactions.

Misfolding and aggregation of amyloid β-40 (Aβ-40) peptide play key roles in the development of Alzheimer's disease (AD). However, very little is known about the molecular mechanisms underlying these molecular processes. We developed a novel experimental approach that can directly probe aggregation-prone states of proteins and their interactions.

Placebo effects on analgesia related to testosterone and premotor activation.

Using functional magnetic resonance imaging, we tested whether graded placebo conditions could modulate the degree of placebo effect and brain activation patterns in study participants and whether the placebo effect could be influenced by hormones. Each participant was investigated under three conditions: the control (no placebo) condition, the low-placebo condition, and the high-placebo condition (HPC). Activations of the premotor areas, anterior cingulate cortex, and prefrontal cortex were stronger in the HPC compared with those in the control and low placebo conditions.

CT findings of an intracardiac bronchogenic cyst.

Bronchogenic cysts are classified as congenital bronchopulmonary foregut malformations. It is very rare for bronchogenic cysts to occur within the heart. A 59-year-old woman had a cardiac mass which was detected incidentally during a CT examination.

Cirrhosis is present in most patients with hepatitis B and hepatocellular carcinoma.

Background & Aims: There are few data available about the prevalence or effects of cirrhosis in patients with hepatocellular carcinoma (HCC) from viral hepatitis. We compared patients with HCC and hepatitis B virus (HBV) or hepatitis C virus (HCV) infections to determine the proportions of cirrhosis in each group, virologic and tumor characteristics, and overall survival.

Methods: This analysis included patients with HBV (n = 64) or HCV (n = 118) infection who were diagnosed with HCC at the Mayo Clinic in Rochester, Minnesota from 1994-2008; groups were matched for age and sex.

Nanoimaging for protein misfolding diseases.

Misfolding and aggregation of proteins are widespread phenomena leading to the development of numerous neurodegenerative disorders such as Parkinson's, Alzheimer's, and Huntington's diseases. Each of these diseases is linked to structural misfolding and aggregation of a particular protein. The aggregated forms of the protein induce the development of a particular disease at all levels, leading to neuronal dysfunction and loss.

A YIDD Mutation in a Case of Recurrent Hepatitis B after Liver Transplantation Induced by an S-escape Mutant.

A 47-year-old woman underwent orthotopic liver transplantation (OLT) for hepatitis B virus (HBV)-related end-stage liver cirrhosis. The patient received hepatitis B immunoglobulin prophylaxis after OLT. Despite the protective level of the serum anti-hepatitis-B surface antibody, HBV recurred at 22 months post-OLT and induced subacute hepatic failure.

Diffusion-weighted MRI at 3 T for the evaluation of prostate cancer.

Objective: The objective of this article is to review the basic concepts for the biologic basis of diffusion-weighted MRI (DWI), illustrate its potential clinical applications at 3 T, and discuss its current limitations and future directions.

Conclusion: The increased signal-to-noise ratio of DWI provided by 3 T compared with 1.5 T may improve tumor detection and staging, determination of tumor aggressiveness, and posttreatment follow-up.

A case of hepatocellular carcinoma with pulmonary metastases treated successfully with a combination of repeated hepatic arterial infusion epirubicin and Cisplatin chemotherapy and systemic low-dose infusion of 5-Fluorouracil.

We report a case of hepatocellular carcinoma (HCC) with pulmonary metastases treated with repeated hepatic arterial infusion chemotherapy (HAIC) comprising epirubicin and cisplatin, and systemic infusion of 5-fluorouracil (a modified EC/F protocol), which led to complete remission. A 49-year-old man with compensated liver cirrhosis experienced intrahepatic recurrence of HCC with extensive lung metastases. The modified EC/F therapeutic protocol, which was applied at the tenth cycle every 4-5 weeks, resulted in disappearance of the pulmonary metastases and normalization of serum alpha-fetoprotein levels.

Randomized clinical trial of long-acting somatostatin for autosomal dominant polycystic kidney and liver disease.

There are no proven, effective therapies for polycystic kidney disease (PKD) or polycystic liver disease (PLD). We enrolled 42 patients with severe PLD resulting from autosomal dominant PKD (ADPKD) or autosomal dominant PLD (ADPLD) in a randomized, double-blind, placebo-controlled trial of octreotide, a long-acting somatostatin analogue. We randomly assigned 42 patients in a 2:1 ratio to octreotide LAR depot (up to 40 mg every 28+/-5 days) or placebo for 1 year.

High-b-value diffusion-weighted imaging at 3 T to detect prostate cancer: comparisons between b values of 1,000 and 2,000 s/mm2.

Objective: The objective of our study was to investigate the diagnostic performance of 3-T MRI of the prostate using diffusion-weighted imaging (DWI) with high b values (1,000 and 2,000 s/mm2) and a phased-array coil in predicting localized prostate cancer.

Materials And Methods: Forty-eight patients underwent single-shot echo-planar DWI at 3 T, followed by radical prostatectomy. DWI was performed at high b values of 1,000 and 2,000 s/mm2.

Surface Induced nanofiber growth by self-assembly of a silk-elastin-like protein polymer.

Many synthetic and natural peptides are known to self-assemble to form various nanostructures. During the self-assembling process, environmental conditions such as salt concentration, pH, temperature, and surface characteristics play a critical role by influencing intermolecular interactions, and hence the process of self-assembly. Here we studied the self-assembly of a genetically engineered protein polymer composed of silk-like and elastin-like repeats on a mica surface.

Imaging of the seminal vesicle and vas deferens.

The seminal vesicle (SV) and vas deferens (VD) are ancillary but essential urogenital organs. Understanding their embryologic features and anatomy can be helpful in evaluating various disorders of these organs. Recently, cross-sectional imaging modalities, including ultrasonography, computed tomography, and magnetic resonance (MR) imaging, have been increasingly used for evaluation of the SV and VD.

A comprehensive analysis of three Asiatic black bear mitochondrial genomes (subspecies ussuricus, formosanus and mupinensis), with emphasis on the complete mtDNA sequence of Ursus thibetanus ussuricus (Ursidae).

In the present paper, we describe the mitochondrial genome sequence of the Asiatic black bear (Ursus thibetanus ussuricus) with particular emphasis on the control region (CR), and compared with mitochondrial genomes on molecular relationships among the bears. The mitochondrial genome sequence of U. thibetanus ussuricus was 16,700 bp in size with mostly conserved structures (e.

MR urography for suspected upper tract urothelial carcinoma.

The key components of the MR urography protocol for suspected upper tract urothelial carcinoma are coronal T2-weighted hydrographic sequences without contrast agent and coronal gadolinium-enhanced T1-weighted 3D-spoiled gradient-recalled echo in nephrographic and pyelographic phases. Upper tract urothelial carcinomas can be categorized into papillary tumor, flat tumor, and infiltrative tumor based on the growth pattern and extent. Papillary lesions appear as small filling defects of soft tissue signal on T2-weighted hydrographic and T1-weighted pyelographic phase images.

Expression of ganglioside GT1b in mouse embryos at different developmental stages after cryopreservation.

Gangliosides are a family of sialic acid-containing glycosphingolipids that are abundant in neurons and have a variety of functions in developing and mature tissues. We examined the expression of ganglioside GT1b in the embryonic preimplantation stage after freezing and thawing processes to determine the regulatory roles of ganglioside GT1b in early embryonic development. ICR mouse embryos at the two-cell stage obtained by flushing the oviducts were frozen by two cryopreservation procedures, slow freezing using a programmable freezer or vitrification by direct plunging into liquid nitrogen.

Comparison of delayed enhanced CT and 18F-FDG PET/CT in the evaluation of adrenal masses in oncology patients.

Objective: To retrospectively compare delayed enhanced computed tomography (CT) and 18F-fluorodeoxyglucose positron emission tomography (18F-FDG PET)/CT (PET/CT) evaluating adrenal masses in oncology patients undergoing both examinations.

Methods: Twenty adrenal masses in 14 patients were retrospectively included. For delayed enhanced CT, a metastasis was diagnosed if a mass had an absolute percentage loss of enhancement value of less than 60%.

Comparison of phased-array 3.0-T and endorectal 1.5-T magnetic resonance imaging in the evaluation of local staging accuracy for prostate cancer.

Objective: To retrospectively evaluate local staging accuracy for prostate cancer at 3.0-T magnetic resonance imaging (MRI) by comparing with that at 1.5-T MRI.

Imaging of the male urethra.

For imaging of the male urethra, conventional radiographic contrast studies including retrograde urethrography are most commonly utilized. They are best suited for delineating luminal abnormalities of the urethra and thus are commonly used as the primary imaging modality for patients with various urethral abnormalities such as trauma, inflammation, and stricture. More recently, the cross-sectional imaging techniques of ultrasound, computed tomography and magnetic resonance imaging have been utilized increasingly for urethral and periurethral abnormalities.