[Histamine levels in interstitial fluid of lesional and perilesional skin in patients with chronic idiopathic urticaria (author's transl)].

In 8 patients with idiopathic chronic urticaria suction blisters were produced simultaneously on lesional and perilesional skin in the periumbilical area without application of heat. The suction pressure was 250 mm Hg, and thus the blister production lasted from 60--120 min. The blister fluid histamine was determined with a modified autoanalyzer technique developed by Siraganian.

Vascular damage in acute experimental leptospirosis of the guinea-pig.

The pathogenesis of the haemorrhagic diathesis in experimental leptospirosis of the guinea-pig was investigated in the lung, diaphragm and kidney. The vascular damage was found to be focal and mainly capillary. Swollen endothelium with dilated endoplasmic reticulum, enlarged mitochondriae and open junctions seemed to be the initial lesions and endothelial necrosis the final picture in all tissues.

Vascular permeability in the rat gingiva. A model of vessel response in chronic inflammation.

The vascular permeability of the vessels of clinically normal gingiva of rats was studied using the colloidal carbon technique. The connective tissue situated underneath the keratinised epithelium was normal, but that subjacent to the non-keratinised epithelium showed some degree of chronic inflammation and as a rule the vessels of the area exhibited increased vascular permeability. In the buccal gingiva the vessels labelled with carbon form loops situated 200 micrometers below the marginal gingiva, while in the interdental gingiva the altered vessels are just below the superficial epithelium.

Hemodynamic responses to low doses of naloxone after narcotic-nitrous oxide anesthesia.

Hemodynamic responses to reversal of phenoperidine-nitrous oxide anesthesia were studied in 14 adult patients before and after naloxone administration (1.5 +/- 0.25 microgram/kg), and, at comparable intervals, in 11 control patients who were permitted to resume respiration spontaneously.

Comparative study of the ultrastructural alterations in the pulmonary vessels of rats treated with alpha-naphthylthiourea (ANTU) and ammonium sulphate.

A comparative study of the ultrastructural changes in rat pulmonary vessels was made in two different situtations of increased vascular permeability: one caused by alpha-naphthylthiourea (ANTU) and the other induced by ammonium sulphate (AS). AS had a more destructive effect on the capillaries but showed little alteration in vessels larger than capillaries. ANTU provoked milder ultrastructural lesions but acted on capillaries, arterial and venous structures.

Morphological study of lesions induced by snake venoms (Naja naja and Agkistrodon piscivorus) in the lung and cremaster vessels of rats.

The morphological effects of two snake venoms, N. naja and A. piscivorus, and of the Direct Lytic Factor and Phospholipase-A, compounds purified from N.

Ultrastructural changes in rat lung arterioles in conditions of altered permeability.

By means of the colloidal carbon technique and injection of a barium-gelatin mixture into the pulmonary artery, the ultrastructure of lung arterioles in a state of increased permeability has been studied. In certain conditions pulmonary arteriolar permeability changes are frequent and the carbon particles adhere to the endothelium. Leakage of carbon into the interstitial space is observed only rarely.

Vascular events in inflammation.

Seven topics of vascular events in inflammation are discussed independently: (1) It is pointed out that too frequently generalizations have been made of vascular phenomena registered in one specific situation, and evidence is given that the existence of a characteristic vascular reaction pattern in the inflammatory processes is doubtful. (2) Considering the results of recent experiments, it is suggested that the role of the nervous system in inflammation should be reassessed. Although its influence seems to be of a minor nature in many "laboratorial" situations, it is of primary importance when nerves are stimulated by electric antidromic excitations and may be relevant in injuries sufficiently severe to damage peripheral nerves.

Decreased vascular reactions to permeability factors in experimental diabetes.

Light and electron microscopic studies showed that blood vessels of the cremaster muscle of alloxan-diabetic rats under the local influence of histamine or serotonin presented less labelling by colloidal carbon, previously injected i.v., than vessels of normal rats.

[Diffuse immunological lung damage due to heterologous anti-thymocyte serum].

Heterologous anti-rat-thymocyte-serum produces an acute hemorrhagic pulmonary lesion. Pneumotoxicity is dependant upon complement since preparatory C' - depletion protects the experimental animal from its letal properties. Absorption of serum with finely dispersed homologous tissue suspensions of lung and thymus is eliminative of toxicity while prophylactic administration of histamin antagonists seems to be non-influential in the genesis of the pulmonary lesions.

[The serological behaviour of the pyogenic anaerobes, Peptococcus asaccharolyticus and P. prevotii (author's transl)].

Using rabbit antisera against whole-cell adjuvant-free antigens, the serological behaviour of ten butyrate-producing Peptococcus strains, five belonging to P. asaccharolyticus and five to P. prevotii, was studied in cross-agglutination and gel-diffusion experiments.