Publications by authors named "Bohao Zhang"

Objective: The primary methods for defining the prognostic risk of AML patients are cytogenetic and molecular analysis at the time of diagnosis. However, the prognosis of intermediate-risk patients is still not well assessed for biomarkers. The main objective of this meta-analysis is to evaluate the relationship between circRNAs and AML prognosis, to provide a theoretical basis for finding effective prognostic indicators in intermediate-risk patients, and to provide an important scientific basis for the development or revision of WHO practice guidelines and ELN risk classification, and to highlight the importance of continuing to focus on and evaluate the prognostic impact of circRNAs on AML in future studies.

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Clinical mastitis (CM) is a prevalent and severe inflammatory disease in dairy cows affecting the mammary glands. Fatty acid (FA) metabolism and associated enzymes are crucial for many physiological and pathological processes in dairy cows. However, the relationships among FA metabolism, FA-associated enzymes, and CM, as well as the mechanisms underlying their interactions, in dairy cows are not fully understood.

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Objectives: Our study aims to examine the value of endovascular therapy (EVT) and its comparison to medical management (MM) in ischaemic stroke patients accompanied by large artery atherosclerosis (LAA) and non-LAA METHODS: modified Rankin scale score (mRS) was evaluated at 90 days post the stroke attack and was considered as the primary outcome. Other outcomes measured in this study included score changes of 0-2 and 0-3 on the mRS. The occurrence of symptomatic intracranial haemorrhage at 24 hours after EVT was also measured as a safety endpoint.

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Article Synopsis
  • Oral squamous cell carcinoma (OSCC) is the most common cancer in the oral cavity, but its prognosis is generally poor, highlighting the need for better understanding of its biology.
  • Researchers analyzed gene expression data from GEO, identifying over 5,100 differentially expressed genes (DEGs) and key signaling pathways linked to OSCC, such as TGF-β/SMAD and PI3K-Akt.
  • The study found that COL11A1 is highly expressed in OSCC and may play a significant role in the disease's development by interacting with specific signaling pathways, suggesting it could be a potential target for future treatments.*
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Sleep disorders are among the common comorbidities of autism spectrum disorder (ASD), which not only affect the daily life and learning ability of children but may also exacerbate other symptoms of ASD, seriously impacting the quality of life of children and their families. Given this, understanding the neurobiological mechanisms of sleep disorders in children with ASD has significant research value for developing effective intervention strategies. Melatonin, 5-HT, and orexin are key neurotransmitters that regulate the sleep-wake cycle.

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  • The study investigates the relationship between inflammatory markers and Meige syndrome (MS), aiming to create a predictive tool (nomogram) for assessing MS risk.
  • Researchers analyzed data from 448 MS patients, using a multivariate logistic regression model to identify five key predictors: RDW, HGB, HDL-C, LMR, and SII.
  • The developed nomogram demonstrated promising predictive ability with moderate accuracy in both training and validation sets, indicating its potential for clinical use in identifying MS risk.
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  • Intravenous thrombolysis with tissue plasminogen activator (tPA) is the main treatment for acute ischemic stroke (AIS), but the reasons for hemorrhagic transformation (HT) post-treatment are unclear.
  • A study showed that histidine-rich glycoprotein (HRG) levels increased shortly after tPA treatment, but interestingly, no increase was observed in patients who developed HT.
  • HRG has potential protective effects against HT by reducing inflammation and neutrophil activity, hinting that managing HRG levels could improve outcomes for stroke patients receiving tPA.
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  • - Non-small cell lung cancer (NSCLC) has a high rate of mortality and is influenced by circular RNAs (circRNAs). This study focuses on circ_0028826's role in NSCLC development.
  • - Researchers employed various techniques like RT-qPCR and western blotting to explore how circ_0028826 affects cell proliferation, migration, and apoptosis in NSCLC, including in vivo tumor models.
  • - Findings show that circ_0028826 promotes NSCLC by increasing IDH2 levels through inhibition of miR-758-3p, suggesting that targeting this mechanism could be a potential treatment strategy for NSCLC.
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Background: Esophageal cancer is a common malignancy of the digestive tract. Despite remarkable advancements in its treatment, the overall prognosis for patients remains poor. Cuproptosis is a form of programmed cell death that affects the malignant progression of tumors.

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During estrus, the poll glands of male Bactrian Camels () become slightly raised, exuding a large amount of pale yellow watery secretion with a characteristic odor that may contain hydrogen sulfide (HS). However, whether HS can be synthesized in the poll glands of male Bactrian Camels and its role in inducing camel estrus remains unclear. This study aimed to identify differentially expressed proteins (DEPs) and signaling pathways in the poll gland tissues of male Bactrian Camels using data independent acquisition (DIA) proteomics.

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Diffusion Kurtosis Imaging (DKI)-derived metrics are recognized as indicators of maturation in neonates with low-grade germinal matrix and intraventricular hemorrhage (GMH-IVH). However, it is not yet known if these factors are associated with neurodevelopmental outcomes. The objective of this study was to acquire DKI-derived metrics in neonates with low-grade GMH-IVH, and to demonstrate their association with later neurodevelopmental outcomes.

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Tails used as inertial appendages induce body rotations of animals and robots-a phenomenon that is governed largely by the ratio of the body and tail moments of inertia. However, vertebrate tails have more degrees of freedom (e.g.

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lncRNA PTCSC3, which stands for Papillary Thyroid Carcinoma Susceptibility Candidate 3, has been found to play a role in various cellular processes, including cell proliferation, apoptosis, and migration, acting as either an oncogene or a tumor suppressor depending on the context. This study investigates the influence of lncRNA PTCSC3, derived from human bone marrow mesenchymal stem cell (hBMSC), on the efficacy of erlotinib (Er)-resistant lung adenocarcinoma (LUAD) cells and elucidates underlying mechanism. The hBMSCs and LUAD (PC9 and A549) cells were employed to establish an Er-resistant LUAD cell model.

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The type II Na/Pi co-transporter (NaPi2b), encoded by the solute carrier (SLC) transporter 34A2 (SLC34A2), is responsible for calcium (Ca) and phosphorus (P) homeostasis. Unbalanced Ca/P metabolism induces mastitis in dairy cows. However, the specific role of SLC34A2 in regulating this imbalance in Holstein cows with clinical mastitis (CM) remains unclear.

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Poly (ADP-ribose) polymerase (PARP) inhibitors have potent anti-inflammatory effects, including the suppression of brain microglial activation. Veliparib, a well-known PARP1/2 inhibitor, exhibits particularly high brain penetration, but its effects on stroke outcome is unknown. Here, the effects of veliparib on the short-term outcome of intracerebral hemorrhage (ICH), the most lethal type of stroke, were investigated.

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Cerebral palsy (CP) is the most common motor disability in children. To ascertain the role of major genetic variants in the etiology of CP, we conducted exome sequencing on a large-scale cohort with clinical manifestations of CP. The study cohort comprised 505 girls and 1,073 boys.

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Oral squamous cell carcinoma (OSCC) is a malignant tumor that occurs in oral cavity and is dominated by squamous cells. The relationship between CDK1, CCNA2, and OSCC is still unclear. The OSCC datasets GSE74530 and GSE85195 configuration files were downloaded from the Gene Expression Omnibus (GEO) database and were derived from platforms GPL570 and GPL6480.

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Objective: Adenoid cystic carcinoma (ACC) is a tumor type derived from glands. However, relationship between CCNA2 and KIF23, and adenoid cystic carcinoma remains unclear.

Methods: GSE36820 and GSE88804 profiles for ACC were obtained from the Gene Expression Omnibus (GEO).

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There is increasing evidence of abnormal neurodevelopmental outcomes in preterm infants with low-grade intraventricular hemorrhage (IVH). The purpose of the study was to explore whether brain microstructure and volume are associated with neuro-behavioral outcomes at 40 weeks corrected gestational age in preterm infants with low-grade IVH. MR imaging at term-equivalent age (TEA) was performed in 25 preterm infants with mild IVH (Papile grading I/II) and 40 control subjects without IVH.

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Objective: This work aimed to explore the prognostic risk factors of lung cancer (LC) patients and establish a line chart prediction model.

Methods: A total of 322 LC patients were taken as the study subjects. They were randomly divided into a training set (n = 202) and a validation set (n = 120).

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Background: The retrograde semi-retrieval technique (RESET) has been described as a modified technique for endovascular thrombectomy (EVT) whose safety and efficacy for intracranial atherosclerosis stenosis (ICAS) patients remain uncertain. This article presents our single-center experience, comparing RESET vs. non-RESET in ICAS patients.

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Background: Preterm infants with necrotizing enterocolitis (NEC) are at high risk of adverse neurodevelopmental outcomes. The aim of this study was to explore the value of diffusion tensor imaging (DTI) combined with serum C-reactive protein (CRP) and procalcitonin (PCT) in evaluating alterations of white matter (WM) microstructure in preterm infants with NEC.

Methods: A retrospective cross-sectional study was conducted in which all participants were consecutively enrolled at The Third Affiliated Hospital of Zhengzhou University from June 2017 and October 2021.

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High-pressure valves are an essential infrastructure for hydrogen refueling stations, and the issue of safety and reliability of their operation affects the efficiency of the entire hydrogen delivery system. Hydrogen ball valves are subjected to high-frequency, rapid reciprocating opening and closing for a long time, and the sealing surface between the valve seat and the ball has an uneven wear distribution problem. In this paper, a theoretical derivation of the seat wear volume and wear depth during the hydrogen ball valve adhesive wear process is presented, and a simulation model based on transient dynamics theory is established to carry out a nonlinear finite element analysis of the dynamic contact and frictional wear of the sealing structure during the opening and closing process of the hydrogen ball valve.

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Background: Experimental studies have demonstrated the neuroprotection of ischemic postconditioning (IPostC) in acute ischemic stroke by attenuating ischemia-reperfusion injury. This study aimed to investigate the safety and tolerability of direct IPostC in both a dog model and patients with acute ischemic stroke treated with thrombectomy.

Methods: The study involved 2 parts.

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Increased poll gland secretion is a major characteristic and indicator of estrus in male Bactrian camels; however, research on these poll glands and their secretion is extremely rare. In this study, we determine the chemical composition of poll gland secretions and identify the key functional substances that regulate seasonal estrus in male camels. A GC/LC-MS dual platform was used to analyze ventral hair (control) and neck mane samples containing poll gland secretions from male Bactrian camels during estrus.

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