Publications by authors named "Bohao Chen"

Recycling of valuable solutes and recovery of organic solvents via organic solvent nanofiltration (OSN) are important for sustainable development. However, the trade-off between solvent permeability and solute rejection hampers the application of OSN membranes. To address this issue, the poly(3,4-ethylenedioxythiophene):poly(styrene sulfonate) (PEDOT:PSS) nanoparticle membrane with hierarchical pores is constructed for OSN via vacuum filtration.

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Three supramolecular architectures, [Cu(dpds)(CO)(HO)]·3HO (), [Cu(dpds)(CO)]·3HO (), and [Cu(dpds)(CO)]·9HO·CHOH () (dpds = 4,4'-dipyridyldisulfide and CO (croconate) = dianion of 4,5-dihydroxycyclopent-4-ene-1,2,3-trione), have been synthesized and structurally characterized. Compound contains two crystallographically independent Cu(II) ions, which are both distorted octahedral geometry with elongation along the croconate- and HO-bound axial positions and bonded with two N atoms of two dpds, two O atoms of one CO , and two HO molecules. Two crystallographically independent dpds ligands, both adopting the bis-monodentate bridging mode, connect two Cu(II) ions to form a one-dimensional zigzag chain-like coordination polymer.

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Memory T cells play a key role in immune protection against cancer. Vaccine-induced tissue-resident memory T (TRM) cells in the lung have been shown to protect against lung metastasis. Identifying the source of lung TRM cells can help to improve strategies, preventing tumor metastasis.

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Background: The spread of emerging SARS-CoV-2 immune escape sublineages, especially JN.1 and KP.2, has resulted in new waves of COVID-19 globally.

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Background: Osteoporosis(OP) is a bone disease under research. Iron overload is a significant risk factor. Iron balance is crucial for bone metabolism and biochemical processes.

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Pulmonary neuroendocrine cells (PNECs) are unique airway epithelial cells that blend neuronal and endocrine functions, acting as key sensors in the lung. They respond to environmental stimuli like allergens by releasing neuropeptides and neurotransmitters. PNECs stand out as the only lung epithelial cells innervated by neurons, suggesting a significant role in airway-nerve communication via direct neural pathways and hormone release.

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  • The study investigates the effects of Curcumenol, a compound from traditional Chinese medicine, on cartilage metabolism dysregulation in knee osteoarthritis (KOA), aiming to clarify its mechanisms of action through advanced techniques like transcriptomics and metabolomics.
  • Using a mouse model of KOA, the researchers administered different doses of Curcumenol and employed various methods to assess its impact on cartilage health and cellular functions.
  • Results showed that Curcumenol reduced cartilage damage, enhanced cartilage repair, and positively influenced extracellular matrix metabolism by regulating specific proteins associated with cartilage health.
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  • The study investigates the relationship between tumor cell-released autophagosomes (TRAPs) and neutrophil extracellular traps (NETs) in breast cancer, focusing on how TRAPs contribute to lung metastasis.
  • Through various experimental methods, the research reveals that TRAPs stimulate NET formation in neutrophils via a specific signaling pathway, leading to immune suppression that aids cancer progression.
  • The findings suggest that targeting TRAP-induced NETs can enhance T-cell function and reduce breast cancer metastasis, indicating potential therapeutic strategies involving DNase I and anti-PD-L1 antibodies.
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  • By varying the amount of AgNO solution used, researchers synthesized different sizes of AgO crystals, including cubes, octahedra, and rhombic dodecahedra, with sizes ranging from 440 nm to 79 nm.
  • X-ray diffraction (XRD) techniques revealed shape-related peak shifts and the presence of bulk and surface layer lattices, indicating changes in crystal structures at different temperatures, including negative thermal expansion behavior.
  • The optical properties of the AgO crystals were influenced by size and facets, with larger particles showing red-shifted bandgaps. Additionally, the study on CuO showed that heating affects the crystal lattice, leading to permanent changes in peak symmetry post-annealing.
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Ethnopharmacological Relevance: Shugan Xiaozhi (SGXZ) decoction is a traditional Chinese medicine used for treating nonalcoholic steatohepatitis (NASH). It has been used clinically for over 20 years and proved to be effective; however, the molecular mechanism underlying the effects of SGXZ decoction remains unclear.

Aim Of The Study: We analyzed the chemical components, core targets, and molecular mechanisms of SGXZ decoction to improve NASH through network pharmacology and in vivo experiments.

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Idiopathic pulmonary fibrosis (IPF) is a devastating disease characterized by progressive scarring of the lungs and resulting in deterioration in lung function. Transforming growth factor-β (TGF-β) is one of the most established drivers of fibrotic processes. TGF-β promotes the transformation of tissue fibroblasts to myofibroblasts, a key finding in the pathogenesis of pulmonary fibrosis.

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Oncolytic virotherapy is an innovative approach for cancer treatment. However, recruitment of myeloid-derived suppressor cells (MDSCs) into the tumor microenvironment (TME) after oncolysis-mediated local inflammation leads to tumor resistance to the therapy. Using the murine malignant mesothelioma model, we demonstrated that the in situ vaccinia virotherapy recruited primarily polymorphonuclear MDSCs (PMN-MDSCs) into the TME, where they exhibited strong suppression of cytotoxic T lymphocytes in a reactive oxygen species-dependent way.

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Article Synopsis
  • Idiopathic Pulmonary Fibrosis (IPF) involves TGF-β activation, leading to lung fibroblasts producing excess collagen and developing scarring in the lungs.
  • * Glycine, an essential amino acid for collagen, is synthesized in fibroblasts through a pathway activated by TGF-β, specifically involving the enzyme SHMT2 and the mitochondrial one-carbon pathway.
  • * The study shows that TGF-β promotes enzymes that allow fibroblasts to accumulate glycine and produce collagen; inhibiting specific enzymes can reduce fibrotic responses, suggesting potential treatments for IPF.*
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Background: Nonalcoholic steatohepatitis (NASH) has caused a significant burden on public health care systems, the economy and society. However, there has still been no officially approved pharmacotherapy for NASH. It has been suggested that oxidative stress and mitochondrial dysfunction play vital roles in NASH pathological progression.

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Knee Osteoarthritis (KOA) is an age-related progressive degenerative joint disease, which is featured with pain, joint deformity, and disability. Accumulating evidence indicated oxidative stress plays a crucial role in the occurrence and development of KOA. Curcumin is a polyphenolic compound with significant antioxidant activity among various diseases while catalase (CAT) is an enzyme degrading hydrogen peroxide in treating oxidative diseases.

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The existence of metallic aluminum in municipal solid waste incineration fly ash (MSWIFA) makes it challenging to recycle MSWIFA into cement materials because expansion occurs in the resultant matrices. Geopolymer-foamed materials (GFMs) are gaining attention in the field of porous materials due to their high-temperature stability, low thermal conductivity and low CO emission. This work aimed to utilize MSWIFA as a foaming agent to synthesize GFMs.

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Idiopathic pulmonary fibrosis (IPF) is a devastating disease characterized by progressive scarring of the lungs and resulting in deterioration in lung function. Transforming growth factor-beta (TGF-β) is one of the most established drivers of fibrotic processes. TGF-β promotes transformation of tissue fibroblasts to myofibroblasts, a key finding in the pathogenesis of pulmonary fibrosis.

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The relationship between glomalin-related soil protein (GRSP) and soil aggregation has been a hot topic of research for its close link to soil stability and quality. However, the short-term cultivation of Eucalyptus poses serious threats to soil stability and nutrient stocks, and the effects of GRSP on soil aggregate stability and macronutrient accumulation remain unclear. The aim is to clarify the potential mechanisms affecting soil aggregate stability and macronutrient accumulation in short-term Eucalyptus plantations.

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Aims: Eucommia is the tree bark of Eucommia japonica, family Eucommiaceae. In traditional Chinese medicine, Eucommia is often used to treat osteoporosis. Quercetin (QUE), a major flavonoid extract of Eucommia japonica, has been reported to have anti-osteoporosis effects.

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BaTiO octahedra, edge-, and corner-truncated cubes, and cubes with four tunable sizes from 132 to 438 nm are synthesized by a solvothermal growth approach. Acetic acid treatment can cleanly remove BaCO impurity. Rietveld refinement of X-ray diffraction patterns and Raman spectra help to confirm the particles have a tetragonal crystal structure.

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Increasing spread by SARS-CoV-2 Omicron variants challenges existing vaccines and broadly reactive neutralizing antibodies (bNAbs) against COVID-19. Here we determine the diversity, potency, breadth and structural insights of bNAbs derived from memory B cells of BNT162b2-vaccinee after homogeneous Omicron BA.1 breakthrough infection.

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We aimed to investigate the preventive effect of high mobility group box 1 (HMGB1)-A box and the mechanism by which it alleviates inflammatory injury in acute liver failure (ALF) by inhibiting the extracellular release of HMGB1. BALB/c mice were intraperitoneally (i.p.

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Background: Metformin (MET) is widely used as a first-line hypoglycemic agent for the treatment of type 2 diabetes mellitus (T2DM) and was also confirmed to have a therapeutic effect on type 2 diabetic osteoporosis (T2DOP). However, the potential mechanisms of MET in the treatment of T2DOP are unclear.

Objective: To clarify the effect of MET in T2DOP and to explore the potential mechanism of MET in the treatment of T2DOP.

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