Publications by authors named "Bohan Xu"

Importance: Treatment-resistant depression (TRD) is a major challenge in mental health, affecting a significant number of patients and leading to considerable burdens. The etiological factors contributing to TRD are complex and not fully understood.

Objective: To investigate the genetic factors associated with TRD using polygenic scores (PGS) across various traits and explore their potential role in the etiology of TRD using large-scale genomic data from the All of Us (AoU) Research Program.

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Polybrominated biphenyls (PBBs) are commonly used flame retardants that pose severe risks to humans. However, there is a lack of systematic research on the transformation process and biological toxicities of PBBs in the environment, which is not conducive to the prevention and control of pollution risks of PBBs. Therefore, the transformation pathways (i.

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Monkeypox was re-emerging in 2022 and spread to more than 100 countries. Two clades of Monkeypox virus (MPXV) result in different lethality rates and varying transmission capabilities. Rapid identification of MPXV and differentiation of its clades and subclades are crucial for effective control of the disease.

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Marine plastic pollution poses a severe threat to the environment and human society, demanding urgent global action. However, efforts are hindered by fragmented legal frameworks, unclear responsibilities, and weak enforcement. The ongoing negotiations on the Draft International Legally Binding Instrument on Plastic Pollution, hereinafter referred to as the "Global Plastic Treaty", may present a potential breakthrough.

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HfZrO thin films have excellent complementary metal-oxide semiconductor compatibility and scalability compared to other ferroelectric materials. This makes them a promising candidate for non-volatile memory applications. However, the polymorphism of the materials presents a challenge in stabilizing the ferroelectric properties.

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Airborne electro-optical countermeasure systems necessitate designs that are both lightweight and miniaturized. This study examines a single-detector composite-axis system that integrates a large-stroke, large-aperture two-axis mirror for coarse tracking tasks and a piezoelectric fast-steering mirror for fine tracking adjustments. Addressing the system's initial pointing and spiral scanning challenges, the study derives dynamic target-pointing equations using coordinate transformation and optical geometry.

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Emerging evidence has shown that assortative mating (AM) is a key factor that shapes the landscape of complex human traits. It can increase the overall prevalence of disorders, influence occurrences of comorbidities, and bias estimation of genetic architectures. However, there is lack of large-scale studies to examine the cultural differences and the generational trends of AM for psychiatric disorders.

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Background: Dysfunction of CD8 T cells in the tumor microenvironment (TME) contributes to tumor immune escape and immunotherapy tolerance. The effects of hormones such as leptin, steroid hormones, and glucocorticoids on T cell function have been reported previously. However, the mechanism underlying thyroid-stimulating hormone (TSH)/thyroid-stimulating hormone receptor (TSHR) signaling in CD8 T cell exhaustion and tumor immune evasion remain poorly understood.

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Imbalance of proinflammatory and anti-inflammatory responses plays a crucial role in the progression of abdominal aortic aneurysms. ILF3, a known modulator of the innate immune response, is involved in cardiovascular diseases. This study aims to investigate the role of ILF3 in abdominal aortic aneurysm formation.

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The capability to reliably program partial polarization states with nanosecond programming speed and femtojoule energies per bit in ferroelectrics makes them an ideal candidate to realize multibit memory elements for high-density crossbar arrays, which could enable neural network models with a large number of parameters at the edge. However, a thorough understanding of the domain switching dynamics involved in the polarization reversal is required to achieve full control of the multibit capability. Transient current integration measurements are adopted to investigate the domain dynamics in aluminum scandium nitride (AlScN) and hafnium zirconium oxide (HfZrO).

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Osteosarcoma (OS) is a heterogeneous malignant spindle cell tumor that is aggressive and has a poor prognosis. Although combining surgery and chemotherapy has significantly improved patient outcomes, the prognosis for OS patients with metastatic or recurrent OS has remained unsatisfactory. Therefore, it is imperative to gain a fresh perspective on OS development mechanisms and treatment strategies.

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Article Synopsis
  • Treatment-resistant depression (TRD) is a complex mental health issue that affects many individuals and poses significant social and economic challenges, which remain poorly understood in terms of its causes.
  • The study aimed to identify genetic factors linked to TRD by using polygenic scores (PGS) derived from large genomic data involving over 292,000 participants in the All of Us Research Program.
  • Key findings revealed that certain PGS related to traits like insomnia and neuroticism increased TRD risk, while higher education and intelligence were associated with lower risk, with these patterns being consistent across multiple data sets within the study.
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Article Synopsis
  • * A new Variational Bayes algorithm, called the zero-inflated variance (ZIV) estimator, has been developed to better analyze zero-inflated neuroimaging data and measure the fraction of variance explained (FVE) and non-null effects (PNN).
  • * In tests using data from the Adolescent Brain Cognitive Development (ABCD) Study, the ZIV estimator showed better performance than traditional models, revealing that whole-brain imaging features are more influential for externalizing behaviors and identifying key neurocircuits linked to specific neurobehavioral
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Investigations on fluorite-structured ferroelectric HfO/ZrO thin films are aiming to achieve high-performance films required for memory and computing technologies. These films exhibit excellent scalability and compatibility with the complementary metal-oxide semiconductor process used by semiconductor foundries, but stabilizing ferroelectric properties with a low operation voltage in the as-fabricated state of these films is a critical component for technology advancement. After removing the influence of interfacial layers, a linear correlation is observed between the biaxial strain and the electric field for transforming the nonferroelectric tetragonal to the ferroelectric orthorhombic phase in ZrO thin films.

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Hyperglycemia accelerates calcification of atherosclerotic plaques in diabetic patients, and the accumulation of advanced glycation end products (AGEs) is closely related to the atherosclerotic calcification. Here, we show that hyperglycemia-mediated AGEs markedly increase vascular smooth muscle cells (VSMCs) NF90/110 activation in male diabetic patients with atherosclerotic calcified samples. VSMC-specific NF90/110 knockout in male mice decreases obviously AGEs-induced atherosclerotic calcification, along with the inhibitions of VSMC phenotypic changes to osteoblast-like cells, apoptosis, and matrix vesicle release.

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Intervertebral disc degeneration (IVDD) is a worldwide disease that causes low back pain and reduces quality of life. Biotherapeutic strategies based on tissue engineering alternatives, such as intervertebral disc scaffolds, supplemented by drug-targeted therapy have brought new hope for IVDD. In this study, to explore the role and mechanism of MnO/GelMA composite hydrogels in alleviating IVDD, we prepared composite hydrogels with MnO and methacrylate gelatin (GelMA) and characterized them using compression testing and transmission electron microscopy (TEM).

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Intimal hyperplasia is a complicated pathophysiological phenomenon attributable to in-stent restenosis, and the underlying mechanism remains unclear. Interleukin enhancer-binding factor 3 (ILF3), a double-stranded RNA-binding protein involved in regulating mRNA stability, has been recently demonstrated to assume a crucial role in cardiovascular disease; nevertheless, its impact on intimal hyperplasia remains unknown. In current study, we used samples of human restenotic arteries and rodent models of intimal hyperplasia, we found that vascular smooth muscle cell (VSMC) ILF3 expression was markedly elevated in human restenotic arteries and murine ligated carotid arteries.

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Neonicotinoid insecticides (NNIs) are a new class of widely used insecticides with certain risks to non-target organisms, like earthworms. The gray correlation method was used to calculate the comprehensive risk effect value of acute toxicity (LC) and bioaccumulation (logK) of NNIs on earthworms. A comprehensive effects three-dimensional quantitative structure-activity relationship (3D-QSAR) model was constructed, using NNIs molecular structures and the comprehensive effect value as the independent and dependent variables, respectively.

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Objectives: Facing the emerging diseases, rapid identification of the pathogen and multi-dimensional characterization of the genomic features at both isolate-level and population-level through high-throughput sequencing data can provide invaluable information to guide the development of antiviral agents and strategies. However, a user-friendly program is in urgent need for clinical laboratories without bioinformatics background to decode the complex big genomics data.

Methods: In this study, we developed an interactive online platform named PHDtools with a total of 15 functions to analyze metagenomics data to identify the potential pathogen and decode multi-dimensional genetic signatures including intra-/inter-host variations and lineage-level variations.

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The substantial development of the dyeing and printing industry has resulted in an increased discharge of dye wastewater containing a large amount of recalcitrant organic pollutants. Furthermore, the landfill disposal of red mud has led to significant environmental pollution such as soil erosion and groundwater contamination. Therefore, this study aimed to promote the resource utilization of red mud by preparing advanced oxidation catalyst, resulting in effective treatment of dye wastewater, and the primary reaction mechanism was revealed.

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Currently, the association between prostate volume (PV) or prostate weight with pathological outcomes in patients with prostate cancer (PCa) is not well understood. This study aimed to explore whether PV can predict the adverse pathological outcomes of PCa patients after radical prostatectomy (RP). A total of 1063 men with confirmed localized PCa who underwent RP at the First Affiliated Hospital of Zhejiang University from January 2014 to April 2019 were retrospectively analyzed.

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In this study, a novel acid-modified red mud biochar catalyst (MMBC) was synthesized by industrial waste red mud (RM) and peanut shell (PSL) to activate peroxodisulfate (PDS) for the degradation of TC. Meanwhile, MMBC exhibited remarkable adsorption capacity, reaching a 60% removal ratio of TC within 60 min (equilibrium adsorption capacity = 12 mg/g). After adding PDS, MMBC/PDS system achieved a 93.

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Zero-inflated outcomes are very common in behavioral data, particularly for responses to psychological questionnaires. Modeling these challenging distributions is further exacerbated by the absence of established statistical models capable of characterizing total signals attributed to whole-brain imaging features, making the accurate assessment of brain-behavior relationships particularly formidable. Given this critical need, we have developed a novel variational Bayes algorithm that characterizes the total signal captured by whole-brain imaging features for zero-inflated outcomes .

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HfZrO(HZO) thin films are promising candidates for non-volatile memory and other related applications due to their demonstrated ferroelectricity at the nanoscale and compatibility with Si processing. However, one reason that HZO has not been fully scaled into industrial applications is due to its deleterious wake-up and fatigue behavior which leads to an inconsistent remanent polarization during cycling. In this study, we explore an interfacial engineering strategy in which we insert 1 nm AlOinterlayers at either the top or bottom HZO/TiN interface of sequentially deposited metal-ferroelectric-metal capacitors.

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The commercially available polyelectrolyte complex poly(3,4-ethylenedioxythiophene):poly(styrene sulfonate) (PEDOT:PSS) is ubiquitous in organic and hybrid electronics. As such, it has often been used as a benchmark material for fundamental studies and the development of new electronic devices. Yet, most studies on PEDOT:PSS have focused on its electronic conductivity in dry environments, with less consideration given to its ion transport, coupled ionic-electronic transport, and charge storage properties in aqueous environments.

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