Assessment of drug-drug interaction of dapagliflozin with LCZ696 based on an LC-MS/MS method.

The co-administration of dapagliflozin (DPF) and sacubitril/valsartan (LCZ696) has emerged as a promising therapeutic approach for managing heart failure. Given that DPF and LCZ696 are substrates for P-glycoprotein, there is a plausible potential for drug-drug interactions when administered concomitantly. To investigate the pharmacokinetic changes when these drugs are co-administered, we have established and validated a liquid chromatography-tandem mass spectrometry (LC-MS/MS) method capable of simultaneously detecting DPF, LBQ657 (the active metabolite of sacubitril) and valsartan in rat plasma.

Catalyst or stumbling block: do green finance policies affect digital transformation of heavily polluting enterprises?

In recent years, China's green finance policies (GFP) have been successively introduced and continuously strengthened, and the effects have been widely observed. Using data from 2007 to 2021, this study employed a continuous double difference model to examine the impact of GFP on the digital transformation (DT) of heavily polluting enterprises (HPEs), as well as its underlying mechanisms. Our results show that GFP is a stumbling block rather than a catalyst that hinders the DT's enthusiasm of HPEs, and it plays an inhibitory role by increasing financing costs and financing constraints.