Impact of levetiracetam and ethanol on memory, selected neurotransmitter levels, oxidative stress parameters, and essential elements in rats.

Background: Ethanol disrupts brain activity and memory. There is evidence supporting the beneficial effect of levetiracetam on alcohol consumption. Therefore, the aim of the study was to examine whether levetiracetam has a protective activity against ethanol-induced memory impairment, alterations in selected neurotransmission activities, oxidative stress, and selected essential elements in rats.

The impact of brivaracetam on cognitive processes and anxiety in various experimental models.

Background: Memory deficits and anxiety symptoms are undesirable effects that occur in epilepsy patients. They may be associated with the pathophysiology of the disease but also with anticonvulsant therapy. Brivaracetam (BRV) is one of the newest antiseizure drugs.

The Effect of Zonisamide and Ethanol on Various Types of Memory in Rats.

Antiepileptic drugs might be useful in the treatment of alcohol use disorder. One of these drugs is zonisamide, which has been found to decrease alcohol intake and cravings. An important structure in the pathophysiology of addiction is the hippocampus.

The differential effect of levetiracetam on memory and anxiety in rats.

Objective: One of the newest antiseizure medication is levetiracetam (LEV). It might be effective in various indications, not only related to convulsions. Central nervous system disorders are common during anticonvulsant therapy.

The antiepileptic drug lacosamide and memory - A preclinial study.

Objective: Lacosamide (LC) belongs to a new generation of antiepileptic drugs (AEDs) and demonstrates unique mechanism of action. The drug also shows neuroprotective activity on the hippocampus. In this study, the impact of LC on learning processes was assessed.

Beneficial effect of retigabine on memory in rats receiving ethanol.

Background: Retigabine belongs to the novel generation of antiepileptic drugs but its complex mechanism of action causes that the drug might be effective in other diseases, for instance, alcohol dependence. It is known that ethanol abuse impaired the function of brain structures associated with memory and learning such as the hippocampus. In our previous study, retigabine reduced hippocampal changes induced by ethanol in the EEG rhythms in rabbits.

The effect of zonisamide on memory processes - A preclinical study.

Objective: Zonisamide is an antiepileptic drug with a perspective of a broader use. Although it is regarded as a relatively safe drug, zonisamide might cause disorders of the central nervous system. The study assessed the influence of zonisamide on spatial and emotional memory in adult Wistar rats.

Can the Impact of Topiramate on Memory Processes be Related to Its 'Antialcoholic Activity'?-A Preclinical Study.

Aims: Topiramate causes the inhibition of alcohol consumption in addicts but the mechanism of this action has not been fully understood yet. Nowadays, it seems that memory may have a role in the development of dependence. In this study, the impact of topiramate and ethanol on the bioelectric activity of the brain in rabbits and on spatial memory in rats was evaluated.

The possibility of adverse effect of Kv7-channel opener retigabine on memory processes in rats.

Objective: Retigabine is a novel antiepileptic drug with a unique and complex mechanism of action which allows its use in many diseases associated with impaired neuronal activity. This study sought to examine the impact of retigabine on two types of memory in rats.

Methods: Adult male Wistar rats were used to assess the effect of retigabine, administered p.

The Impact of Zonisamide on the Development and Course of Alcohol Dependence in Rabbits. A pharmaco-EEG study.

Aims: Zonisamide is a new anti-epileptic drug whose mechanism of action is associated with neurotransmission systems also involved in the pathogenesis of addiction. Recently, the role of memory processes and the hippocampus (Hp) is underlined in dependence. In our previous study, we determined that zonisamide decreases changes in hippocampal bioelectric activity induced by a single dose of ethanol.

Does retigabine affect the development of alcohol dependence?--A pharmaco-EEG study.

New antiepileptic drugs have been investigated for their potential role in the treatment of alcohol dependence. One of these drugs is retigabine and this study examines the effect of retigabine co-administered with ethanol on the development of alcohol dependence and the course of acute withdrawal syndrome. A pharmaco-EEG method was used to examine this impact in selected brain structures of rabbits (midbrain reticular formation, hippocampus and frontal cortex).

[Long-term use of estrogens: benefit or risk].

Estrogens are widely used in hormone replacement therapy, gynecology, urogynecology and rarely in dermatology. Non-therapeutic use of estrogens is very widespread. Estrogens are used as contraceptives, which cause a lot of serious side effects.

A pharmaco-EEG study of the interaction between ethanol and retigabine in rabbits.

Background: Retigabine is a new antiepileptic drug with multiple mechanisms of action. It may well interact with ethanol, as both have an influence on GABA-ergic and glutamate neurotransmission.

Objectives: To assess the effect of retigabine, administered as single or repeated doses, on ethanol-induced changes in the bioelectric activity of selected brain structures in rabbits.

A pharmaco-EEG-based assessment of the interaction between ethanol and zonisamide.

Aims: Recent research suggests a potential role for a new generation of anticonvulsant drugs, including zonisamide, in the treatment of alcohol dependence. Some elements of the central mechanism of action that zonisamide has in common with ethanol, give rise to the question of whether there is an interaction between these two agents and whether there is any risk associated with the enhanced depressive effect of these agents on the central nervous system.

Methods: This study uses a pharmaco-EEG method to examine the interaction of ethanol with zonisamide.

Effect of topiramate on hippocampus-dependent spatial memory in rats.

Background: Topiramate, a new generation antiepileptic agent with a complex mechanism of action, has a broad pharmacological profile which includes a neuroprotective effect. It has been proven to be efficacious in treating alcohol dependence through a previously confirmed association with memory processes.

Methods: Topiramate was administered in single doses of 120 and 40 mg/kg and multiple doses of 60 mg/kg for 12 days.

[Retigabine - a new antiepileptic drug with a different mechanism of action].

Retigabine belongs to a new generation of antiepileptic drugs. Its mechanism of action is different from that previously known. Retigabine opens potassium channels of subfamily Kv 7, especially Kv 7.

[The role of the cannabinoid system in the pathogenesis and treatment of alcohol dependence].

The lack of satisfactory results of alcohol dependence treatment force us to search for new directions of research. Recent studies concentrate on endocannabinoid transmission. The results show an interplay between the endocannabinoid and dopaminergic signaling in activation of the limbic reward system.

[The role of the glutamatergic system in the pathogenesis and treatment of alcohol dependence].

The lack of satisfactory results of alcohol dependence treatment has necessitated the search for new directions of studies. One of them is connected with glutamatergic transmission. The influence of alcohol on this transmission is very complex and relates to changes including at the molecular level.

Pharmaco-EEG-based assessment of the interaction between ethanol and oxcarbazepine.

Oxcarbazepine is a representative molecule for a new class of anticonvulsant drugs that can treat alcohol dependence in addition to other disorders. Interestingly, the central mechanism of action in oxcarbazepine is very similar to ethanol, suggesting that these two agents may interact and cause enhanced effects in the central nervous system. In this study, we used a pharmaco-EEG method to examine the influence of oxcarbazepine on the effect of ethanol on the EEG of rabbits (midbrain reticular formation, hippocampus, frontal cortex).

Pharmaco-EEG-based assessment of interaction between ethanol and levetiracetam.

Recent research suggests a potential role for a new generation of anticonvulsant drugs, including levetiracetam, in the treatment of alcohol dependence. Some elements of the central mechanism of action that levetiracetam has in common with ethanol, give rise to the question of whether there is an interaction between these two agents and whether there is any risk associated with the enhanced depressive effect of these agents on the central nervous system. In this study, we have used a pharmaco-electroencephalographic (EEG) method to examine the interaction of ethanol with levetiracetam.

Effect of combined administration of ethanol and tiagabine on rabbit EEG.

Tiagabine is a new generation antiepileptic drug, a specific inhibitor of gamma-aminobutiric acid (GABA) reuptake from the synaptic space to neurons and glia. Central effect of ethanol is mainly connected with its effect on GABAergic, glutamatergic, serotonergic and opioid transmission. The mechanism of tiagabine effect suggests that it may alleviate the rewarding effect of ethanol, which can be applied in the treatment of addiction.

The effect of combined administration of ethanol and gabapentin on rabbit electroencephalographic activity.

The central effect of ethanol is mainly connected with the effect on GABAergic, glutamatergic, serotonergic and opioid transmission. The mechanism of gabapentin effect suggests that it may alleviate the rewarding effect of ethanol, which may be used in the treatment of addiction. We decided to examine the interaction of ethanol with gabapentin by a pharmaco-electroencephalographic (EEG) method.

Effect of the administration of tiagabine and gabapentin on rabbit electroencephalogram activity.

New generation antiepileptic drugs, including gabapentin and tiagabine, are used in monotherapy or in combination with other drugs for specific seizure types. The multidirectional mechanism of activity and varied pharmacological properties of these drugs suggest that they could also be used in the therapy of other diseases. A possible limitation of new generation antiepileptic drugs is the incidence of CNS-related adverse effects.

Effect of the combined administration of ethanol and acamprosate on rabbit EEG.

Central effect of ethyl alcohol and acamprosate is based on similar mechanisms. It is mainly connected with their effect on GABAergic, glutamatergic, serotonergic and opioid transmission. Thus, the question arises whether acamprosate administered together with alcohol increases acute central effects of ethanol.

Influence of felbamate on selected central effects of ethanol in experimental animals.

Both felbamate and ethanol demonstrate complex action on central nervous system (CNS). There are several data indicating that ethanol influences pharmacokinetics of new generation of antiepileptic drugs. Investigation of CNS interaction of felbamate and ethanol may bring up some suggestions as for adverse reactions of concomitance of these substances and consequences of such reactions are concerned.