Expression, localization and systemic concentration of vascular endothelial growth factor (VEGF) and its receptors in patients with ulcerative colitis.

Vascular endothelial grow factor (VEGF) promotes angiogenesis by activating the specific receptors KDR and Flt-1. We investigate the expression of genes encoding VEGF and its receptors KDR and Flt- 1 by RT-QPCR reaction using Quanti Tect SYBR Green RT-PCR in patients with active and inactive ulcerative colitis (UC) and control subjects. The localization and level of VEGF protein and its receptors protein in intestinal tissue were estimated by immunohistochemistry.

[The picture of abdominal cavity wall after surgical treatment of postoperative abdominal hernia with the Matapurkar's method of "peritoneal sandwich" in pathomorphological examinations].

In this work the results of autopsy are presented--of a 45 years old man who died because of complications of cirrhosis in 24 months after repairing a postoperative hernia with the Matapurkar's "peritoneal sandwich" and polypropylene mesh. Macroscopically and histopathologically it has been shown that gradual healing of the mesh ends with formation of alloplastic-tissue connective structure, called neofascia that fills in the defect in fascia of the abdominal wall. Inflammatory process around implanted mesh maintains even after several months.