[DIAGNOSTIC VALUE OF THE HOMEOSTASIS PARAMETERS IN SEPSIS DETECTING IN PATIENTS WITH INFECTIOUS-INFLAMMATORY COMPLICATIONS DURING THE POSTOPERATIVE PERIOD.].

Unlabelled: Purpose of the study was to define the diagnostic value of clinical and laboratory criteria of sepsis during the postop- erative period Methods. The results of 269 blood tests (biochemical, coagulation, hematology and microbiology) which were per- formed in 115 patients in the early postoperative period (starting from the first postoperative day) and in the late post- operative periods were analyzed.

Results: Presepsin and procalcitonin have a similar diagnostic sensitivity in detection of sepsis - 89% (Psp>328.

[DIAGNOSTIC AND THERAPEUTIC BRONCHOSCOPY IN PATIENTS UNDERGOING CARDIAC SURGERY IN INTRA- AND POSTOPERATIVE PERIODS].

The article presents research conducted to evaluate the use of diagnostic and therapeutic fiberoptic bronchoscopy in the treatment of ventilator-associated pneumonia (VAP) and tracheobronchitis in patients in cardiac ICU. The paper presents the results of the study and comparison of invasive techniques for sampling from the respiratory tract for bacteriological analysis. We studied the bacterial profile of ICU, original content of the respiratory tract of cardiac patients in the intraoperative period and possible ways for prevention of VAP and tracheobronchitis in the postoperative period using bronchoscopy.

[Types of infectious complications exciters in recipients of related kidneys].

Aim: To investigate the nature of microflora causing an infectious-inflammatory complications in recipients of related kidney in the early postoperative period and to substantiate the effectiveness of antibiotic prophylaxis and antibiotic therapy depending on pathogen type with the determination of its sensitivity to antimicrobial agents.

Material And Methods: The medical records of 255 patients who underwent kidney transplantation from a living related donor from 2007 to 2014 were analyzed. Foci of infection were sanitized preoperatively to prevent infectious complications in post-transplantation period.

[Effect of radio frequency discharge plasma on surface properties and biocompatibility of polycaprolactone matrices].

Surface modification of bioresorbable polymer material (polycaprolactone, PCL) with abnormal glow discharge, initiated during radio-frequency magnetron sputtering of a hydroxyapatite target was investigated. Plasma treatment resulted in an increase of surface roughness of PCL, crystallite size, the surface free energy and hydrophilicity. Increased treatment time (30, 60, 150 seconds) provoked the polymer surface saturation with the sputtering target ions (calcium, phosphorus).

[IN VIVO EVALUATION OF POLYCAPROLACTONE-HYDROXYAPATITE SCAFFOLD BIOCOMPATIBILITY].

Biocompatibility is one of the main and very important properties for scaffolds. The aim of the present study was to investigate cells population dynamics in vivo in the process of original polycaprolactone-hydroxyapatite scaffold colonization, as well as tissue reactions to the implantation to assess the biocompatibility of the matrix. It has been found that tissue reactive changes in white rats subside completely up to the 21st day after subcutaneous polycaprolactone-hydroxyapatite scaffold implantation.

[Infectious complications after kindred kidney allotransplantation].

It was analyzed the medical records of 231 patients who underwent living kindred donor kidney transplantation. Early postoperative complications were observed in 51 (22%) patients including infectious events in 30 cases namely pyelonephritis (13), pneumonia (6), sepsis (5), wound infection (3), pulmonary tuberculosis (2) and esophageal mycosis (1). Microflora investigation revealed predominantly gram-negative bacteria including enterobacteriaceae (K.

[THE ROLE OF MICROBIOLOGICAL MONITORING AND DRUG HISTORY IN THE EFFECTIVENESS OF ANTIBIOTIC PROPHYLAXIS AND ANTIBIOTIC TREATMENT OF INFECTIOUS COMPLICATIONS AFTER RECONSTRUCTIVE SURGERIES].

Material And Methods: We analyzed the results of the local microbiological monitoring carried out in 2010-2013. The monitoring included the study of biological material of patients with clinical signs of infectious and inflammatory complications after reconstructive surgery. We studied the dynamics of the isolation of major pathogens (Staphylococcus spp.

[Postoperative bleeding in tracheal surgery].

Aim: Tracheal surgery became relatively safe with development of thoracic surgery, endoscopy and anesthesia. However, life-threatening vascular complications especially arrosive bleeding from great vessels play important role in the structure of postoperative complications. It is a major cause of hospital mortality after tracheal surgery.

[Clinical and bacteriological characteristic of infectious purulent complications in patients after related renal transplantation].

We investigated the frequency and characteristics of infectious purulent and non-infectious complications in living related renal transplant recipients in early postoperative period. It was identified the prevalent microorganisms in urinary tract infections and its antibiotic sensitivity: Pseudomonas aeruginosa, Escherichia coli, Klebsiella pneumoniae, Enterobacter cloacae, Citrobacter freundii, Staphylococcus epidermidis, Enterococcus faecalis, Candida albicans. 182 strains of bacteria and Candida were isolated from urine of renal graft patients in early postoperative period (from 2 days to 3 months).

[Problem of treatment for pyo-inflammatory complications caused by Acinetobacter].

The article deals with analysis of a detection frequency and antibacterial treatment resistance of Acinetobacter spp.of different species affiliation. Strains of bacteria detected in patients with pyo-inflammatory complications after surgeries (period from 2010 to 2012) were involved in the study 137 strains of Acinetobacter spp.

[Chemotherapeutical department: surgical infection prevention and treatment in ICU].

The article discusses the issues of chemotherapeutical department organization and functioning in multidisciplinary surgical hospital. In connection with a worldwide spread of antibiotic-resistant agents of surgical infections, it becomes necessary to unite efforts of surgeons, resuscitation specialists, clinical pharmacologists - chemiotherapeutists and microbiologists. The main approaches in solving of surgical infection problems are: in-hospital epidemiological situation monitoring, the study ofmicroflora resistance to antibiotics used in the surgical and resuscitation practice, the study of antibacterial therapy clinical-pharmacological aspects (pharmacokinetics, pharmacodynamics, tolerance and efficacy of antimicrobial drugs).

[Dioxidin: antimicrobial activity and prospects of its clinical use at present].

In vitro activity of dioxidin against pathogens of nosocomial infections and its cytotoxicity were estimated. The study involved 300 isolates from patients with nosocomial infections. The MICs of dioxidin were determined with the method of serial dilutions in broth.

[Nosocomial infectious complications after transplantation of allogenic kidneys from the related donor].

The comprehensive evaluation of infectious complications after kidney transplantation from the living related donor was performed. Microbes predominantly encountered in urinary tract infection (P. aeruginosa, K.

[Microbiological monitoring in therapy of patients with iatrogenic esophageotracheal fistula].

The results of the microbiological diagnosis of infective inflammatory complications in patients with iatrogenic esophageotracheal fistula and the tactics of their antibacterial prophylaxis and therapy within a 9-year observation period (2003-2011) were analysed. The main organisms colonizing the tracheobronchial tree in the patients were S. epidermidis, S.

[Effect of clarithromycin on the systemic inflammatory response syndrome severity in patients after myocardial revascularization surgery].

The aim is to investigate the effectiveness of SIRS pharmacological correction in patients after CABG when adding clarithromycin to the standard antibacterial therapy. Patients of the 1st group (n=25) received Klacid- CP ("Abbott") in perioperative period plus to standard antibacterial therapy (3rd generation cephalosporins), patients of 2nd group received standard therapy. At 1st screening stage, as well as on the 2-nd and 4-th day after operation were recorded data of an anamnesis, concomitant pathology, examination, were measured the level of white blood cells, LII, biochemical blood analysis (CRP), defined the concentration of interleukins (IL-1, 6, 8,10,12) and TNF - a.

[Antibiotic resistance dynamics and isolation rate of staphylococci and enterococci from patients of reconstructive surgery units].

The dynamics of isolation of staphylococci and enterococci from clinical material of patients and their antibiotic susceptibility within a 5-year period (2005-2009) was analysed. 5990 isolates were tested: 1250 isolates of Staphylococcus aureus, 3268 isolates of S. epidermidis, 1005 isolates of Enterococcus faecalis and 467 isolates of E.

[Infectious complications in patients with iatrogenic diseases of the trachea and esophagus].

Methods for microbiological monitoring could analyze the microflora isolated in 372 patients with iatrogenic diseases of the trachea and esophagus, who were treated at the Department for Surgery of the Lung and Mediastinum, Acad. B. V.

[Nonfermentative gram-negative bacteria: isolation rates and antibiotic sensitivity].

The isolation rates of nonfermentative gram-negative bacteria (NFGNB) are analyzed in the inpatients treated at the B. V. Petrovsky Russian Surgery Research Center in 2005-2009 and antibiotic resistance trends in nosocomial strains of NFGNB are traced in the above period.

[Dynamics of acquires resistance in the main gramnegative pathogens of surgical infections to beta-lactams in 2004-2008].

Resistance of 2134 clinical isolates of etiologically significant species of gramnegative bacteria to 5 beta-lactam antibiotics, i. e. cefepime, piperacillin/tazobactam, cefoperazone/sulbactam, imipenem and ceftazidime (the 3rd generation cephalosporin) as the reference drug was investigated for the period of 5 years (2004-2008).

[Antimicrobial and antimycotic therapy in the surgery of iatrogenic esophageal and tracheal diseases].

Microbiologic analysis of tracheal and gastrostomic discharge was performed in 327 patients with iatrogenic injuries of trachea and esophagus, operated during 2003-2008. Main groups of microorganisms, colonizing the tracheobronchial tree were defined. St.

[Rational prophylaxis and treatment of infectious complications in kidney transplantation].

Clinical and bacteriological assessment of purulent complications in kidney transplantation has been carried out. The main infectious agents were S. epidermalis, E.

[Study of the revascularizing properties of the greater omentum for creating prefabricated complex autografts under experimantal conditions].

The revascularizing properties of the greater omentum used as a vascular pedicle for the prefabrication of skin, skin/cartilage or skin/ bone autografts, and their viability after rotation and recipient zone infection were studied in rat experiments. The experiment showed that complexity factor did not have a significant effect on the revascularizing properties of the greater omentum, and required only an insignificant prolongation of prefabrication period. Skin/omental, skin/cartilageous, and skin/bony autografts based on the greater omentum formed by day 7, 14, and 21, respectively.

[Micromorphometric parameters of human skin as a marker of skin involution in age determination in forensic medicine].

The mathematical analysis of quantitative micromorphometric parameters of different human skin sites on section material has revealed a significant age-related thinning of the skin and its layers, decreased depth of the salivary and sweat glands position. It is proposed to use micrometric skin parameters for expert examination to define a biological age of the examinee.

[Microbiological monitoring in prophylaxis and treatment of pyoinflammatory complications during early postoperative period in patients with cicatricial tracheostenosis].

The species composition and antibiotic susceptibility of microflora isolated from patients with cicatricial tracheostenosis (CTS) and infectious processes were investigated. Schemes for the treatment of CTS with an account of the pathogen species and multidrug resistant staphylococcal infection are described. Comparative efficacy of the combined schemes (antibiotic + bacteriophage) for the therapy of pyoinflammatory processes in the patients with CTS and the efficacy of the treatment of the patients with CTS according to the traditional antibacterial schemes were studied.

[Problems of prophylaxis and treatment of infectious complications in reconstructive surgery].

Infectious complications due to polyresistant staphylococci as well as strepto- and enterococci are of serious problem in reconstructive surgery, since the number of such strains isolated within 1999-2004 has amounted to 58.4-59.7% of all the isolates.