Unique Severe COVID-19 Placental Signature Independent of Severity of Clinical Maternal Symptoms.

Background: Although the risk for transplacental transmission of SARS-CoV-2 is rare, placental infections with adverse functional consequences have been reported. This study aims to analyse histological placental findings in pregnancies complicated by SARS-CoV-2 infection and investigate its correlation with clinical symptoms and perinatal outcomes. We want to determine which pregnancies are at-risk to prevent adverse pregnancy outcomes related to COVID-19 in the future.

Endometriosis of the Bartholin gland: a case report and review of the literature.

Background: In this case report we present a case of endometriosis in the Bartholin gland without surgery in the perineal area. So far, only five cases concerning endometriosis in the Bartholin gland, which may or may not be an isolated finding, have been reported in the literature.

Case Presentation: A 31-year-old Indo-surinamese woman with primary infertility presented at our out-patient clinic with cyclical vulvar pain.

First trimester physiological development of the fetal foot position using three-dimensional ultrasound in virtual reality.

Aim: In anatomic studies of the embryo, it has been established that during the development of the lower limb, several changes in foot position can be observed defined as a temporary 'physiological clubfoot'. The aim of this study was to develop and test a measurement tool for objective documentation of the first trimester foot position in vivo and made an attempt to create a chart for first trimester foot position.

Methods: We developed a virtual orthopedic protractor for measuring foot positioning using three-dimensional virtual reality visualization.

Evaluation of First-Trimester Physiological Midgut Herniation Using Three-Dimensional Ultrasound.

Introduction: The aim of this study was to investigate the development of midgut herniation in vivo using three-dimensional (3D) ultrasonographic volume and distance measurements and to create reference data for physiological midgut herniation in ongoing pregnancies in a tertiary hospital population.

Materials And Methods: The transvaginal 3D ultrasound volumes of 112 women, seen weekly during the first trimester of pregnancy, were obtained and subsequently analysed in a virtual reality environment. The width of the umbilical cord insertion, the maximum diameter of the umbilical cord, and the volume of midgut herniation were measured from 6 until 13 weeks gestational age (GA).

A viable caesarean scar pregnancy in a woman using a levonorgestrel-releasing intrauterine device: a case report.

Background: Although the levonorgestrel-releasing intrauterine device (LNG-IUD) is one of the most reliable methods of contraception, it is associated with an increased risk of ectopic pregnancy in case of unintended pregnancy. A rare form of ectopic pregnancy is the caesarean scar pregnancy (CSP), with a high risk of serious maternal morbidity, such as uterine rupture, massive haemorrhage and resulting infertility. This report describes the first case of a viable CSP at 13 weeks of gestation in association with the use of a LNG-IUD.

Human embryonic curvature studied with 3D ultrasound in ongoing pregnancies and miscarriages.

Embryonic growth is often impaired in miscarriages. It is postulated that derangements in embryonic growth result in abnormalities of the embryonic curvature. This study aims to create first trimester reference charts of the human embryonic curvature and investigate differences between ongoing pregnancies and miscarriages.

Accuracy of fetal sex determination in the first trimester of pregnancy using 3D virtual reality ultrasound.

Purpose: Early detection of fetal sex is becoming more popular. The aim of this study was to evaluate the accuracy of fetal sex determination in the first trimester, using 3D virtual reality.

Methods: Three-dimensional (3D) US volumes were obtained in 112 pregnancies between 9 and 13 weeks of gestational age.

Diagnosis of acute myocardial infarction in hemodialysis patients may be feasible by comparing variation of cardiac troponins during acute presentation to baseline variation.

Acute myocardial infarction (AMI) is defined as a dynamic change in cardiac troponin (cTn) with at least one cTn value exceeding the 99 th percentile of a reference population in combination with typical clinical symptoms. In hemodialysis (HD) patients, a broad range of cTn concentrations is found, partially due to patient-specific comorbidities. Therefore, the 99 th percentile cannot be used in HD patients and decision algorithms to diagnose AMI should be based on temporal variations of troponin.

Renal pelvis rupture during pregnancy: diagnosing a confusing source of despair.

We present an impressive case of a pregnant woman presenting with severe right flank pains. A rare rupture of the right renal pelvis turned out to be the cause of her problems. Renal pelvis rupture in pregnancy is difficult to diagnose.

Postpandemic Influenza A/H1N1pdm09 is still Causing Severe Perinatal Complications.

Although influenza A/H1N1pdm09 is not causing a pandemic anymore, we recently observed two critically ill pregnant women infected by this virus. We present these cases to illustrate the possible severe complications of an - at that moment - seasonal influenza in pregnancy. We discuss the epidemiological differences between the pandemic and post pandemic phase and try to explain the high virulence of influenza A/H1N1pdm09 -infections in pregnancy by discussing insights in immunology during pregnancy.

First trimester size charts of embryonic brain structures.

Study Question: Can reliable size charts of human embryonic brain structures be created from three-dimensional ultrasound (3D-US) visualizations?

Summary Answer: Reliable size charts of human embryonic brain structures can be created from high-quality images.

What Is Known Already: Previous studies on the visualization of both the cavities and the walls of the brain compartments were performed using 2D-US, 3D-US or invasive intrauterine sonography. However, the walls of the diencephalon, mesencephalon and telencephalon have not been measured non-invasively before.

Complications of the 2009 influenza A/H1N1 pandemic in pregnant women in The Netherlands: a national cohort study.

The 2009 influenza A/H1N1 pandemic caused an increase in complications in pregnant women. To be well prepared for a next pandemic, we investigated the obstetric and maternal complications of this pandemic. In our national cohort of 59 pregnant women who were admitted to the hospital, no major complications apart from preterm birth and admission to the neonatal intensive care unit were observed.

No apparent impact of increased post-operative blood glucose levels on clinical outcome in kidney transplant recipients.

Background: Our objective is to evaluate whether hyperglycemia in the first 48 h after renal transplantation is independently associated with rejection, post-operative infection and post-transplant diabetes mellitus (PTDM) in a retrospective cohort study.

Methods: Patients who received a renal transplant in our hospital in 2003 or 2004 were included. Glucose values until 48 h after surgery were retrieved from laboratory reports.

Contrast-enhanced three-dimensional power Doppler angiography of the human prostate: correlation with biopsy outcome.

Objectives: To determine the feasibility of contrast-enhanced three-dimensional (3D) imaging of the prostatic vasculature using power Doppler imaging and to analyze whether semiquantitative judgments of 3D images with respect to symmetry and distribution of vascular structures correlated with biopsy outcome.

Methods: 3D power Doppler images were obtained before and after intravenous administration of 2.5 g Levovist.

Effects of gonadectomy and exogenous gonadal steroids on sex differences in open field behaviour of adult rats.

Two experiments were carried out to investigate the contribution of gonadal hormones to the expression of sex differences in open field behaviour of adult female and male rats. In the first experiment rats were gonadectomized or sham-operated in adulthood and tested in the open field 1, 2, 3, 4, 5 or 6 weeks later (3 min/rat on 3 consecutive days during the light period of the day). It was found that following gonadectomy the well known sex difference in ambulation and rearing behaviour (females more than males), as well as in defaecation (females less than males) remained.