[The lymph and blood microcirculatory beds of the pancreas in the early period of experimental acute pancreatitis].

Results of the study evidence that in the early period of acute experimental pancreatitis (AEP)--from 10 minutes to 2 hours--changes in acino-capillary complex consist in compensatory-adaptive reaction and are related to metabolic disorders. Abortive interstitial oedema disappears in 20-30-minutes, dilated lymphatic vessels being visible macroscopically. Further progress of oedema with consequent focal haemorrhagic pancreonecrosis is possible in case of insufficient lymphatic drainage.

[Topochemical aspects of pyrimidine specificity of ribonuclease A].

To get insight into the origin of pyrimidine specificity of ribonuclease A, a study of the enzyme interaction with the substrate analogs having a modified nucleobase was undertaken. Pyridine and pyrimidine cyclophosphates were obtained by phosphorylation of 2'(3')-O-dibutyl stannylidene derivatives of nonprotected nucleosides in high yields. The results of kinetic and NMR studies suggested that a substrate should be locked in anti-conformation in the productive enzyme-substrate complex as it was shown for the crystalline complexes of the enzyme with pyrimidine nucleotides by X-ray analysis.