Publications by authors named "Bogdan Was"

Highly localized radiotherapy with radionuclides is a commonly used treatment modality for patients with unresectable solid tumors. Herein, we propose a novel α-nanobrachytherapy approach for selective therapy of human epidermal growth factor receptor 2 (HER2)-positive breast cancer. This uses local intratumoral injection of 5-nm-diameter gold nanoparticles (AuNPs) labeled with an α-emitter (At), modified with polyethylene glycol (PEG) chains and attached to HER2-specific monoclonal antibody (trastuzumab).

View Article and Find Full Text PDF

Introduction: The purposes of the present work were to label substance P (5-11) with At using a rhodium(III) complex with a bifunctional ligand-2-(1,5,9,13-tetrathiacyclohexadecan-3-yloxy)acetic acid ([16aneS]-COOH) and to assess the in vitro stability and toxicity of the obtained radiobioconjugate.

Methods: Two approaches were evaluated to obtain I/At-Rh[16aneS]-SP radiobioconjugates, based on 2-step and 1-step syntheses. In the first method I/At-Rh[16aneS]-COOH complexes were obtained that required further coupling to a biomolecule.

View Article and Find Full Text PDF

The paper summarizes results of investigation of the current state of radioactive contamination on site being under consideration for planned nuclear power plant in northern Poland. Thanks to use of sequential procedure it was possible to determine activity concentrations for radioisotopes of nine elements, both natural and artificial. Results show that observed levels of radioactive contamination are rather typical for central Europe and global fallout is dominant factor of presence of artificial radionuclides.

View Article and Find Full Text PDF