Proteasomes in the brain of β2-microglobulin knockout mice.

MHC class I molecules play an important role in synaptic plasticity of the mammalian nervous system. Proteolytic complexes (proteasomes) produce oligopeptides that are presented on cell surfaces in complexes with MHC class I molecules and regulate many cellular processes beside this. The goal of the present work was to study peculiarities in functioning of proteasomes and associated signaling pathways along with evaluation of NeuN and gFAP expression in different sections of the brain in mice with knockout of β2-microglobulin, a constituent of MHC class I molecules.

[Effect of the state of graphite surfaces on the activity of immobilized glucose oxidase].

The work deals with immobilization of glucose oxidase on modified graphite. The effect of the carrier surface composition on the major properties of the immobilized enzyme was examined. The level of activity of the immobilized enzyme is shown to depend on the quantity of Ti and Zr oxides applied on the graphite surface.