[Effect of amino acids on the growth of a B. polymyza 1538 culture and the biosynthesis of polymyxin B].

The effect of a number of the most important amino acids on the growth of B. polymyxa 1538 and polymyxin B biosynthesis was studied. It was found that all of the amino acids tested except D-L-threonin and L-alpha-gamma-DABA inhibited the initial growth of the organism.

[Effect of phosphorus on polymyxin B biosynthesis by B. polymyxa 1538 on media of varying makeup].

The effect of phosphorus on biosynthesis of polymyxin B by B. polymyxa 1538 was studied and its optimal concentration in the synthetic and two complex media was determined. Correlation between the culture growth and consumption of the main components, on the one hand, and concentration of phosphorus in the medium, on the other hand, was found.

[Importance of corn extract components for the biosynthesis of polymyxin B by B. polymyxa strain 1538].

The effect of some components of corn-steep liquor, such as biotin, organic nitrogen, inorganic phosphorus and other mineral elements on biosynthesis of polymyxin B by B. polymyxa, strain 1538 was studied. It was found that biotin and organic nitrogen had the most significant effect on the antibiotic accumulation.

[Effect of different salts and their concentration on polymyxin M biosynthesis by Bac. polymyxa Ross].

The effect of various concentrations of ammonium sulfate, sodium and potassium chlorides and sulfates on biosynthesis of polymyxin M by Bac. polymyxa Ross. on media containing wheet meal as the carbon source was studied.