Production of Curcuminoids in .

Curcumin, a hydrophobic polyphenol derived from the rhizome of the herb , possesses diverse pharmacological properties, including anti-inflammatory, antioxidant, antiproliferative, and antiangiogenic activities. Two curcuminoids (dicinnamoylmethane and bisdemethoxycurcumin) were synthesized from glucose in . (phenylalanine ammonia lyase) or (tyrosine ammonia lyase), along with (-coumaroyl-CoA ligase) and (curcumin synthase) genes, were introduced into , and each strain produced dicinnamoylmethane or bisdemethoxycurcumin, respectively.