A Model of Acute Peritonitis.

The biological models used in the study of generalized peritonitis can be subdivided into 5 groups (introduction of foreign bodies, cultures of microorganisms, suspensions of feces, chemicals, and mechanical damage to the gastrointestinal tract) or into 4 groups (introduction of foreign bodies, chemicals, bacterial contamination of the abdominal cavity, and combined methods). After analysis of published reports, the most justified classification of methods of peritonitis modelling is based on the type of peritonitis-inducing agent and the administration route and on the nature of peritonitis developing in the abdominal cavity. The choice of the model maximally close reproducing clinical conditions of peritonitis should be based on the specific objectives of the study, focusing on the etiology, pathogenesis, and severity of the disease course, planned measures aimed at eliminating the process, and other factors.

Simulation of Mechanical and Thermal Wounds of Soft Tissues.

Millions of accidental and surgical injuries of soft tissues are registered annually around the world [5]. Untimely and insufficiently effective treatment of wounds in 50-70% leads to the development of purulent-septic infection and the development of septic conditions and fatal outcomes [1-4], which necessitates thorough study of inflammatory and regenerative processes occurring in the injured soft tissues. Various models of mechanical and thermal damage to soft tissues are proposed for studying the inflammatory and reparative processes, for assessing the therapeutic effects and developing new approaches to wound treatment.

[Parallel pharmacological correction of myocardial dysfunction, cognitive and psychopathological disordres in patients with congestive heart failure].

Was examined 92 patients with congestive heart failure III-IV FC with fraction of emission left ventricle < 45% against coronary artery disease. Patients of control group received basic therapy (according to recommendations of the Ukrainian society of cardiology), the 1 group--in addition received a preparation of Vazonat within 15 days intravenously in a dose of 1000 mg a day further are out-patient within 1 month on 250 mg 3 times per os; the 2 group--under the same scheme a preparation of Vazonat and a day tranquilizer of Adapto in a dose of 500 mg twice a day throughout all term of supervision. It is established that addition of Vazonat to basic treatment leads to additional effect concerning improvement of indicators cardio-hemodynamic, to improvement congestive functions.

[Gastroprotective action of the nettle extract in experimental peptic ulcer].

Nettle extract produced from leaves crushed to 40-70 nm fragments protects the stomach mucous membrane, and does it better than the extract derived from same leaves crushed to 1 mm fragments, on the models of peptic ulcers caused by acetylsalicylic acid, histamine, prednisolone, and immobilized stress. The antiulcer activity of the nettle extract from 40-70 nm fragments is comparable with the effect of buckthorn oil. Nettle extracts also hinder the excess acid secretion and diminish the acidity of stomach juice in experimental peptic ulcer caused by pylorus ligation.

[Effect of the treatment with fenigidin on peripheral hemodynamics in patients with stable angina pectoris].

Peripheral arterial and venous hemodynamics were investigated by plethysmography method in 32 patients with functional classes II-III angina pectoris. The course of phenihidinum treatment in daily dose of 30-40 mg during three weeks was found beneficial on arterial and venous tone. The therapy decreases pre- and heart afterload in such patients without any side effects.

[Changes in the blood content of some vitamins in patients with ischemic heart disease].

A study concerning vitamins A, C, E content in the blood of 22 patients with stable exercise-induced angina and in those patients (n = 28) with postinfarction cardiosclerosis without circulation failure was carried out. In patients with stable exertional angina, the blood plasma content of vitamin C has been shown to be on the increase, those patients with postinfarction cardiosclerosis revealed a rise in vitamin A in erythrocytes and that in vitamin C in blood plasma. After successful antianginal therapy the content of vitamin C in the blood plasma and erythrocytes has gotten normalized, that of vitamin A in red cells has also returned to normal.

[Effect of antianginal therapy on lipid peroxidation in patients with ischemic heart disease].

Measurement of the blood lipid peroxidation products (lipid hydroperoxides, dienic ketones, and malonic dialdehyde) was carried out in 26 patients with stable angina of effort and in 31 patient with postinfarction cardiosclerosis with due regard for the ejection fraction (intact, reduced) before treatments administration and after institution of antianginal therapy (nitrates, beta-adrenoblockers, nifedipine). The antianginal therapy has been shown to have but insignificant effect on both blood plasma contents of dienic ketones and plasma/erythrocyte content of malonic dialdehyde, which fact is regarded as an indication for use of antioxidant agents.

[The evaluation of pharmacological tests with nitroglycerin, anaprilin, korinfar and No-Shpa in patients with stable stenocardia of effort].

Acute pharmacological tests were done in 47 patients with stable II-III functional class angina of effort. Indices for central hemodynamics were determined with the aid of Iu. T.

[The indices of intracardiac hemodynamics in patients with postinfarct cardiosclerosis].

Endocardiac hemodynamics was studied in 81 patients with postinfarction cardiosclerosis with intact and decreased ejection fraction (EF > 57% and EF < 57% respectively) using echocardiographic B- and M-mode techniques. Patients with postinfarction cardiosclerosis without overt heart failure demonstrated a decline in the left ventricular pump function which was more manifest in postinfarction cardiosclerosis presenting with a decreased ejection fraction. A decline in the pump function of the myocardium in those patients having postinfarction cardiosclerosis without overt cardiac insufficiency is an indication for prescription of those medicinal substances enhancing the inotropic function of the myocardium (cardiac glycosides, peripheral vasodilators).

[Effects of fenigidin treatment regimen on the state of peripheral hemodynamics of patients with stable effort angina pectoris and postinfarction cardiosclerosis].

Aim: To examine the impact of fenigidin treatment regimen on peripheral hemodynamics in patients with stable angina pectoris of effort and postinfarction cardiosclerosis without signs of heart failure.

Materials And Methods: Thirty two patients with functional classes II and III stable angina of effort and 32 with postinfarction cardiosclerosis without signs of heart failure were examined.

Results: Monotherapy with fenigidin, 30-40 mg/day in patients with stable angina pectoris of effort and in those with postinfarction cardiosclerosis lowered systolic and mean blood pressures, total and specific peripheral vascular resistance, venous tone and increased additional venous volume and maximum vein emptying rate in the upper and lower extremities.

[A comparative evaluation of the efficacy of magneto- and laser therapy in patients with osteoarthrosis deformans].

A comparative evaluation of efficacy of magneto- and laser therapy was carried out in 82 patients with osteoarthrosis deformans. The magnetic field and laser irradiation dispelled the pain syndrome and synovitis manifestations. It is recommendable that the multiple-modality therapy of patients with osteoarthrosis deformans should involve magneto- and laser therapy (15 to 20 procedures per one course) that improve results of the treatment being received and allow the time of hospitalization to be reduced at an average by 5 bed-days.

[The impact of the intravenous He-Ne laser therapy on the antioxidant system in patient with stable exertion angina and postinfarct cardiosclerosis].

The authors' study show that intravenous He-Ne laser therapy (HNLT) in patients with stable angina of effort (functional class II-III) and postinfarction cardiosclerosis irrespective of ejection fraction increased plasma katalase and red cell vitamin A concentrations. HNLT aroused vitamin E concentration in red cells in anginal patients with intact ejection fraction whereas in those with reduced ejection fraction it elevated blood peroxidase, plasma vitamin A and E concentrations. For patients with postinfarction cardiosclerosis there were, respectively, higher levels of blood peroxidase, plasmic vitamin A, red cell vitamin E, plasmic SH-groups and blood peroxidase, plasmic vitamins A and E.