Publications by authors named "Boesen N"
Introduction: Hyperphosphorylation and aggregation of the microtubule-associated protein tau cause the development of tauopathies, such as Alzheimer's disease and frontotemporal dementia (FTD). We recently uncovered a causal link between constitutive serotonin receptor 7 (5-HT7R) activity and pathological tau aggregation. Here, we evaluated 5-HT7R inverse agonists as novel drugs in the treatment of tauopathies.
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- Tau oligomers are crucial in tau pathology, leading to neuronal cell death and disease transmission in the brain, making their prevention a key focus for treating tauopathies like Alzheimer's disease.
- A new tau-BiFC platform was developed to detect and quantify tau oligomerization, which helped identify levosimendan as a strong candidate that inhibits this process effectively.
- Levosimendan not only binds to tau proteins, preventing their aggregation but also reverses tau oligomerization, showing promise as a disease-modifying drug for tau-related disorders in mice models.
Objective: To investigate the association between β-amyloid (Aβ) load and postmortem structural network topology in decedents without dementia.
Methods: Fourteen decedents (mean age at death 72.6 ± 7.
Self-control is the ability to control one's impulses when faced with challenges or temptations, and is robustly associated with physiological and psychological well-being. Twin studies show that self-control is heritable, but estimates range between 0% and 90%, making it difficult to draw firm conclusions. The aim of this study was to perform a meta-analysis to provide a quantitative overview of the heritability of self-control.
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