Interrelationships between the metabolism of thyroid hormones and the liver. Part one.

The paper deals with the biosynthesis of the thyroid hormones and with their metabolism, which takes place in many tissues, mainly in the liver. The liver exerts effects on thyroid hormone distribution, metabolism and disposal. It supplies the thyroglobulin--storage form of thyroid hormones--and the plasma proteins with which they are bound.

Renin and aldosterone reactions after acute hemorrhage.

Among the pressor homeostatic mechanisms that appear after hemorrhage are renin-angiotensin response and aldosterone hypersecretion. Plasma renin activity (PRA) may decrease initially but increase always after a certain interval. Aldosterone secretion increases or decreases in a higher or lower degree.

Phospholipid variation in acute ethanol intoxication in rats.

The effects of acute ethanol intoxication in different rat organs were studied with 32P. Since 32P incorporation in all compounds of cell membrane formation faithfully illustrate their structural and functional integrity, levels of 32P labelled phospholipids, from different organs were investigated in acute experiments. Researches were carried out on male rats, by administering doses of 3.

Biochemical correlations between some organs and the liver after acute ethanol intoxication in rats.

The influence of different doses of ethanol on the phospholipid metabolism in rat was investigated with 32P. Male rats received by oral intubation a single intoxicating dose of ethanol (3.5 or 5.

Serum alphaphetoprotein in chronic hepatitis. Scintigraphic correlations.

On studying a number of 59 patients with chronic active hepatitis and with hepatic cirrhosis, with 37% and 41% cases respectively our research-works have proved increased serum AFP concentrations varying between 30-45 ng/ml, their values being much larger in active hepatic cirrhosis. The significant increase in aminotransferase and bilirubin has been correlated with a more severe stage of the hepatic disease. The gamma glutamyltranspeptidase (GGTP) assays for 9 of the 17 cases with active chronic hepatitis and for 17 cases with alcoholic hepatitis have shown a 6-15 times increase of this enzyme as compared to the other cases.

Glycoproteins behaviour in ankylopoietic spondylarthritis.

Glycoproteins behaviour in ankylopoietic spondylarthritis (SA) is studied by dosing sialic acid in blood and urine on 12 patients in comparison with 10 rheumatoid polyarthritis (RP) and 39 other nonspecific osteo-articular disease cases; the values are referred to those found on normal persons. A significant statistic increase of the sialic acid is found in SA. There are also comparatively studied, on the same lots of patients, the ratio albumin/globulin (A/G), the values of the proteinaemia, of the globulins and the blood sedimentation rate (BSR).