Preemptive analgesia: no relevant advantage of preoperative compared with postoperative intravenous administration of morphine, ketamine, and clonidine in patients undergoing transperitoneal tumor nephrectomy.

Background And Objectives: Preemptive analgesia often failed in the clinical arena because application of a single intravenously applied drug may not prevent nociceptive input and spinal pain processing sufficiently. We therefore used an intravenous (IV), multireceptor approach and tested the preemptive analgesic effect of the antinociceptive drugs morphine, ketamine, and clonidine given before or immediately after surgery.

Methods: A double-blind, randomized, prospective study was performed in 30 patients undergoing transperitoneal tumor nephrectomy (via median laparotomy).

Long-term use of tamsulosin to treat lower urinary tract symptoms/benign prostatic hyperplasia.

Purpose: The long-term efficacy and safety of 0.4 mg. tamsulosin once daily were assessed in patients with lower urinary tract symptoms/benign prostatic hyperplasia treated for up to 4 years.

Results of a European comparative randomized study comparing oral bropirimine versus intravesical BCG treatment in BCG-naive patients with carcinoma in situ of the urinary bladder. European Bropirimine Study Group.

Objectives: This European phase III clinical trial was part of an intercontinental study which was closed prematurely by the sponsor. The study was designed to compare the effects of oral bropirimine with intravesical BCG, the current standard treatment in patients with newly diagnosed bladder carcinoma in situ (CIS).

Methods: A total of 55 BCG-naive patients with bladder CIS were randomized to receive bropirimine (n = 27) or BCG (n = 28).

Tamsulosin, the first prostate-selective alpha 1A-adrenoceptor antagonist. A meta-analysis of two randomized, placebo-controlled, multicentre studies in patients with benign prostatic obstruction (symptomatic BPH). European Tamsulosin Study Group.

Objective: This meta-analysis of two European studies evaluated the efficacy and safety of modified-release tamsulosin 0.4 mg once daily compared with placebo in patients with benign prostatic enlargement, lower urinary tract symptoms and prostatic obstruction (symptomatic BPH).

Methods: Patients entered a 2-week placebo run-in period, followed by randomization to treatment with tamsulosin (382 patients) or placebo (193 patients) once daily for 12 weeks.

[Microsurgical, neuroprotective plaque isolation in plastic penile induration].

Conservative therapy of Peyronie's disease has not given very encouraging results. This means operative treatment strategies are the only effective therapy form that appears to be successful. Another treatment form, which often leads to a non-acceptable shorting of the penis, is the technique used in the Schröder-Essed and Nesbit procedures.

[Long-term follow-up of nephrectomy for hypernephroma in 442 patients].

The long-term-results of 442 patients with nephrectomy because of hypernephroma are analysed with regard to preoperative findings, surgical technique and postoperative therapy. Until 1971 conventional nephrectomy was performed, since then a modification with a long incision carried medially and "blind" manual preparation of the renal pedicle has been performed. This led to better long-term-results.

[Experience with tumors in solitary kidneys without hypothermia nor extracorporal surgery (author's transl)].

Our experience with carcinoma in solitary kidney is presented. We prefer the enucleation of the tumor or the partial resection of the kidney in normothermic ischemia. Two patients underwent total nephrectomy and hemodialysis.

[Complete subpelvine rupture of ureter as the only sequela of a trauma (case report and references) (author's transl)].

A complete subpelvine rupture of the right ureter of a nine year old girl is presented. After a short review of literature, the mechanism of the trauma and the resulting facts of this rare injury are being discussed. The excretion urography is the most important part of diagnosis.

[A simple apparatus to facilitate epididymectomy (author's transl)].

A simple apparatus is introduced which facilitates the preparation of testicular vessels in epididymectomy using diaphania. The applicability of this apparatus is being tested in other fields of surgery.

[In vitro perfusion of so-called endoprothesis. An experimental study of incrustations on internal splinting plastic tubes (author's transl)].

We have used the method of internal splinting of the ureter (endoprothesis) for the past ten years. Because we observed partial obstruction of the lumen by incrustations and/or fibrin coagula in cases in which the splints had been in place for long periods, we conducted in vitro experiments into the problem. Under constant and variable conditions, urine was perfused through plastic tubes of different materials.

[Operative correction of primary megaureter in children (author's transl)].

Sixty-seven children with congenital megaureter were treated by surgically. Nephroureterectomy was performed in 12 cases (17.9%).

[Results of pyeloplasty in children (author's transl)].

The results of 47 surgically corrected cases of stenosis of the pyelo-ureteral junction in children are presented. The method of Anderson-Hynes is preferred because of the removal of the functionally and morphologically damaged ureter-segment. In 80% of the cases the postoperative x-ray demonstrated a good result.

[Ureterlesion in laparoscopic sterilisation of the Fallopian tube (author's transl)].

A case of severe ureterlesion following sterilisation of the Fallopian tube is presented. Since 28 days elapsed before operative relief of the kidney was attempted reconstructive surgery of the ureter at a later date proved to be unsuccessful. A secondary nephrectomy had to be performed.

[Treatment of renal hypertension by nephrectomy in persons over 40 years of age].

42 patients aged over 40 years at the time of nephrectomy (between 1961 and 1972) for unilateral renal disease and arterial hypertension were re-investigated. The WHO criteria for normotensive and hypertensive blood pressure levels were used. Systolic and diastolic pressures returned to normal after nephrectomy in 15 patients, systolic pressure alone in nine.

[An enzymatic method for the isolation of tubules and cells from human kidney cortex].

The isolation of tubules and cells from human kidney cortex was realized by an enzymatic method. Tubules and cells were released from slices of kidney cortex by collagenase. The yield amounted to 80 % of the wet weight of incubated cortex slices.