Correlation of Two-Minute and Six-Minute Walk Tests With Spirometric Indices in Patients With Severe Chronic Obstructive Pulmonary Disease at a Selected Tertiary Care Hospital in Puducherry.

Background Chronic obstructive pulmonary disease (COPD) is a progressive respiratory condition characterised by airflow limitation and reduced exercise capacity. The Six-Minute Walk Test (6MWT) and Two-Minute Walk Test (2MWT) are commonly used to assess functional exercise capacity in COPD patients. This study aims to evaluate the correlation between the distance covered in the 2MWT and 6MWT with spirometric indices (such as Forced Expiratory Volume in 1 second (FEV₁), Forced Vital Capacity (FVC), and FEV₁/FVC) in COPD patients.

Effects of the first frozen-thawed embryo transfer time on pregnancy outcomes after progestin primed ovarian stimulation regimen.

This was an original article, mainly explored the effects of the first frozen-thawed embryo transfer (FET) time on pregnancy outcomes after progestin primed ovarian stimulation (PPOS) regimen. Our study implemented a retrospective analysis of 315 infertile patients who underwent in vitro fertilization and embryo transfer (IVF-ET) treatment from January 2021 to June 2023. Patients were divided into three groups based on their first FET time.

The contribution of nonmedical opioid use to healthcare encounters for opioid overdose and use disorders among long-term users with metastatic cancer.

Purpose: Opioid misuse is increasingly recognized as a relevant problem among patients with cancer. However, the applicability of these concerns for patients with metastatic disease is complicated by shorter prognoses and greater symptom burden. This study aimed to investigate whether nonmedical opioid use (NMOU) was identified as contributing to opioid-related healthcare encounters among patients with metastatic cancer receiving long-term prescribing.

Investigating the toxicity of malachite green and copper sulfate in brine shrimp: and computational study.

Colour is crucial for enhancing the appetizing value and consumer acceptance of food products. The commonly used food colourants and food preservatives such as Malachite Green (MG) and Copper Sulfate (CS) can cause severe health problems. This study investigates the toxicity of these food-grade colourants through acute exposure using cytotoxicity using the brine shrimp model including 3D surface analysis (3DSA) and studies Brine shrimp were treated with various concentrations of MG and CS.

Advances and challenges in therapeutic resistant biomarkers of neuroblastoma: A comprehensive review.

Therapeutic resistance is one of the significant challenges in Neuroblastoma. Owing to its molecular diversity, the therapeutic resistance mechanisms of Neuroblastoma are highly complicated. The traditional chemo and radio therapeutics fail to provide adequate solutions to the treatment resistance, demanding in-depth research to improvise the existing prognostic and therapeutic regimens.

Phase disposition PWM control topology based: A novel multilevel inverter with reduced switch for power electronics applications.

In the field of industrial drive applications, a neutral point clamped multilevel inverter (NPC MLI) is an extensively used option. The NPC MLI architecture involves more number of components for higher level and higher switching frequency operation. In this work paper, a novel three-phase 3-Level MLI is proposed evading the usage of clamping diodes and quadratic switches.

A Novel Fluorescent Sensor for Detecting Ag and Hg ions: A Combination of Theoretical and Experimental Studies.

A new fluorescent sensor based on diethylaminosalicylaldehyde-thiosemicarbazide (DST) was studied using a combination of density functional theory calculations and experimental investigations. DST was able to detect the metal ions Ag and Hg in the presence of various competing metal ions and anions, with detection limits of 0.45 and 0.

Multiphoton Dissociative Ionization of Gas-Phase Styrene.

We performed multiphoton ionization of styrene molecules and observed the formation of styrene and benzene cations, the latter being reported for the first time in the multiphoton ionization of styrene. The formation of the benzene cation reveals an internal conversion from the S state to the S state, which occurs via a S/S conical intersection at 4.66 eV above the minimum of the S state.

Delay in Time to Adjuvant Chemotherapy and its Impact on Oncological Outcomes in Patients Undergoing Optimal Cytoreductive Surgery for Advanced Ovarian Cancer: Analysis of 1480 Cases From the Indian HIPEC Registry.

Background And Objectives: The impact of delay in initiation of adjuvant chemotherapy following optimal CRS in different settings of treatment for advanced ovarian cancer needs to be studied with special reference to CRS HIPEC.

Methods: The 1480 advanced EOC patients underwent optimal CRS, followed by adjuvant chemotheraphy, with or without intraperitoneal (IP) chemotherapy in Normothermic or Hyperthermic form. Interval between the day of surgery and start of adjuvant chemotherapy and its impact on outcome was analyzed.

Land use & land cover dynamics and its relationship with nitrate pollution in groundwater around inactive mine areas using geospatial techniques, SW part of Cuddapah basin, Southern India.

Geospatial maps can show how the ineffective operations of inactive mines affect water and aquifer quality. As such, the purpose of this study is to assess the impact of mining and irrigation on the aquifer ecosystem through the evaluation of LULC and slope maps through the application of Landsat 8 OLI/TIRS and DEM data. A total of 50 groundwater samples were prepared from villages in the close proximity to inactive mines during pre and post monsoon periods in 2021.

Effectiveness of Ultraviolet Radiation and Disinfectant Wipes in Reducing the Microbial Contamination of Mobile Phones in a Tertiary Care Hospital.

Background As mobile phones act as a potential source of microbial contamination, particularly in a hospital environment, the effectiveness of two most debated interventions namely ultraviolet radiation and disinfectant wipes in reducing the microbial contamination of mobile phones is compared. Objective To screen the mobile phones of healthcare personnel for the presence of microorganisms and to compare the effectiveness of ultraviolet radiation and disinfectant wipes in reducing microbial contamination. Methods and materials Pre-intervention and post-intervention swabs were collected before and after the use of each intervention respectively using 56 samples and cultured for growth in nutrient agar.

A hybrid model for the classification of Autism Spectrum Disorder using Mu rhythm in EEG.

Background: Autism Spectrum Disorder (ASD) is a condition with social interaction, communication, and behavioral difficulties. Diagnostic methods mostly rely on subjective evaluations and can lack objectivity. In this research Machine learning (ML) and deep learning (DL) techniques are used to enhance ASD classification.

Adherence to weekly iron folic acid supplementation and associated factors among adolescent girls - A mixed-method study.

Context: Despite the Weekly Iron folic acid supplementation (WIFS) program, the prevalence of anaemia among adolescent girls remains high. Phase 1 Indian Council of Medical Research (ICMR) task force study conducted in 2016 in Kallur showed that the IFA provision rate for adolescent girls was 72% but the consumption rate was only 15% in the Kallur area. The present study was done to identify the gaps for the difference between provision and consumption rate of weekly IFA tablets among adolescent girls using the WHO conceptual framework in home-based settings.

The Clinical Profile of Newly Diagnosed Acute Myeloid Leukemia at a Tertiary Care Center in South India: A Cross-Sectional Study.

Background and objective Acute myeloid leukemia (AML) is a heterogeneous and aggressive blood malignancy prevalent among both children and adults, accounting for a significant proportion of acute leukemia cases worldwide. Our study aimed to shed light on the demographic and clinical profile and risk stratification of newly diagnosed AML cases at a tertiary care government hospital in South India. Methods We conducted a cross-sectional study involving 221 patients with AML in the Department of Clinical Hematology, Rajiv Gandhi Government General Hospital and Madras Medical College, Chennai, Tamil Nadu from January 2020 to December 2022.

Circulating small extracellular vesicles in Alzheimer's disease: a case-control study of neuro-inflammation and synaptic dysfunction.

Background: Alzheimer's disease (AD) is a neurodegenerative disease characterized by Aβ plaques and neurofibrillary tangles. Chronic inflammation and synaptic dysfunction lead to disease progression and cognitive decline. Small extracellular vesicles (sEVs) are implicated in AD progression by facilitating the spread of pathological proteins and inflammatory cytokines.

A preclinical study to determine the anti-epileptic effect of biotin on maximal electroshock (MES) and pentylenetetrazole (PTZ) models in albino rats.

Objectives: Vitamin B7(biotin) is not synthesized in our body and is retrieved from some food products like eggs, liver, pork and leafy vegetables and as well as microbes of gut. Deficiency of biotin majorly leads to loss of hair, rashes over skin, lethargy and seizures. It is noted that biotin is an anti-oxidant and negates free radical effects.

Cognitive behavioral and mindfulness with daily exercise intervention is associated with changes in intestinal microbial taxa and systemic inflammation in patients with Crohn's disease.

Crohn's disease (CD) is a chronic inflammatory bowel disease associated with psychological distress and intestinal microbial changes. Here, we examined whether a 3-month period of Cognitive Behavioral and Mindfulness with Daily Exercise (COBMINDEX) intervention, which improves the wellbeing and inflammatory state of CD patients, may also affect their gut microbiome. Gut microbiota, circulating inflammatory markers and hormones were analyzed in 24 CD patients before (T1) and after 3 months of COBMINDEX (T2), and in 25 age- and sex-matched wait-list control patients at the corresponding time-points.

Identification, validation and quantification of thymoquinone in conjunction with assessment of bioactive possessions and GC-MS profiling of pharmaceutically valuable crop Nigella ( L.) varieties.

Background: Plants have been pivotal in traditional and modern medicine globally, with historical evidence supporting their therapeutic applications. Nigella ( L.) is an annual herbaceous plant of the Ranunculaceae family and is cultivated in the Middle East, Eastern Europe, and Western and Central Asia.

Efficient EEG motion artifact elimination framework for ambulatory epileptic seizure detection application.

Motion artifacts are a pervasive challenge in EEG ambulatory monitoring, often obscuring critical neurological signals and impeding accurate seizure detection. In this study, we propose a new approach of outlier based grouping of two level Singular Spectrum Analysis (SSA) decomposition combined with Relative Total Variation (RTV) filter for the effective removal of motion-induced noise from ambulatory EEG data. A two-stage SSA method was employed to decompose single-channel EEG signal, which had been interfered with, into various fre quency bands.

Salivary Chloride Intracellular Channel 1 (CLIC1) as a Hub of Gene-Gene Interactome of Periodontitis With Diabetes Mellitus.

Background and introduction Periodontal disease is one of the most prevalent chronic conditions that affects the oral cavity. Identifying and predicting biomarkers is essential for the prevention of high-morbidity oral diseases. The genomic interaction network identifies common hub genes involved in crucial protein formation in periodontal inflammation.

Effect of internal fractures on mechanical properties and failure of sandstone under multi-physical fields.

Under deep mining conditions, rocks are subjected to complex multi-physical fields and can contain numerous pores and fractures. To explore the influence and correlation of these factors on the physical and mechanical properties of fractured rock samples, this study conducted triaxial compression tests on sandstone specimens under various physical conditions using a rock full stress multi-field coupling triaxial tester. Additionally, a random fracture model for multi-field coupling numerical simulation was established.

Correction: SRY gene isolation from teeth for forensic gender identification-An observational study.

[This corrects the article DOI: 10.1371/journal.pone.

Comparison of Chemical Composition, Quality, and Muscle Fiber Characteristics between Cull Sows and Commercial Pigs: The Relationship between Pork Quality Based on Muscle Fiber Characteristics.

This study aims to compare the chemical composition, quality, and muscle fiber characteristics of cull sows and commercial pigs, investigating the effect of changes in muscle fiber characteristics on pork quality. The proximate composition, color, pH, water-holding capacity (drip loss and cooking loss), protein solubility, total collagen content, and muscle fiber characteristics of cull sows (n=20) and commercial pigs (n=20) pork were compared. No significant differences were found between cull sows and commercial pigs in terms of proximate composition, drip loss, protein solubility, or total collagen content of their meat (p<0.

Rediscovery and systematics of Rhinophis fergusonianus Boulenger, 1896 (Serpentes: Uropeltidae) from Indias Western Ghats.

The shieldtail snake Rhinophis fergusonianus Boulenger, 1896 was previously known only from the holotype specimen collected approximately 130 years ago from an imprecise Indian locality (Cardamom Hills). We report the rediscovery of this species from four localities, from low-elevation hills on both sides of the Palghat Gap in the southern part of the Western Ghats of peninsular India. We document new specimens of R.