The Clinical Complexity of Penile Cancer: Current Clinical-Epidemiological Data from the Database of the Free State of Saxony/Germany.

Objectives: The aim of this study was to assess penile cancer incidence, clinical characteristics, treatment options, transparency of clinical quality, and relative survival based on data from the clinical cancer registry.

Subjects And Methods: A total of 898 patients with tumours of the penis were diagnosed and analysed in the period from 2000 to 2018; they were documented in the 4 regional clinical cancer registries and summarized in the Command Office of these 4 registries.

Results: The standardized incidence rate increased from 0.

Pediatric Life-Threatening Coronavirus Disease 2019 With Myocarditis.

We report the case of a pediatric life-threatening coronavirus disease 2019 who presented as myocarditis with heart failure. Clinicians should be aware of this severe presentation of the disease in children, possibly linked to an exaggerated inflammatory host immune response to severe acute respiratory syndrome coronavirus 2.

Development of KIINCE: A kinetic feedback-based robotic environment for study of neuromuscular coordination and rehabilitation of human standing and walking.

Introduction: The objective of this article is to introduce the robotic platform KIINCE and its emphasis on the potential of kinetic objectives for studying and training human walking and standing. The device is motivated by the need to characterize and train lower limb muscle coordination to address balance deficits in impaired walking and standing.

Methods: The device measures the forces between the user and his or her environment, particularly the force of the ground on the feet () that reflects lower limb joint torque coordination.

Frequency-dependent contributions of sagittal-plane foot force to upright human standing.

Quiet standing is a mechanically unstable postural objective that humans typically perform with ease. Control of upright posture requires stabilization of both translational and rotational degrees-of-freedom that is accomplished by neuro-muscular coordination. This coordination produces a force at the ground-foot interface (F) that is quantified by magnitude, direction (θ), and point of application (center-of-pressure, CP).

Post-Stroke Walking Behaviors Consistent with Altered Ground Reaction Force Direction Control Advise New Approaches to Research and Therapy.

Recovery of walking after stroke requires an understanding of how motor control deficits lead to gait impairment. Traditional therapy focuses on removing specific observable gait behaviors that deviate from unimpaired walking; however, those behaviors may be effective compensations for underlying problematic motor control deficits rather than direct effects of the stroke. Neurological deficits caused by stroke are not well understood, and thus, efficient interventions for gait rehabilitation likely remain unrealized.

Ankle torque control that shifts the center of pressure from heel to toe contributes non-zero sagittal plane angular momentum during human walking.

A principle objective of human walking is controlling angular motion of the body as a whole to remain upright. The force of the ground on each foot (F) reflects that control, and recent studies show that in the sagittal plane F exhibits a specific coordination between F direction and center-of-pressure (CP) that is conducive to remaining upright. Typical walking involves the CP shifting relative to the body due to two factors: posterior motion of the foot with respect to the hip (stepping) and motion of the CP relative to the foot (foot roll-over).

Mechanical interaction of center of pressure and force direction in the upright human.

Humans maintain upright bipedal posture by producing appropriate force against the environment through the interaction of neural controlled muscle force with the mechanics of the skeletal system. Characterizing these mechanics facilitates understanding of the neural control. We used a mechanical model of an upright human to analyze how the mechanical linkage aspects of the human body affect the force between the feet and the ground (F).

Force direction pattern stabilizes sagittal plane mechanics of human walking.

The neural control and mechanics of human bipedalism are inadequately understood. The variable at the interface of neural control and body mechanics that is key to upright posture during human walking is the force of the ground on the foot (ground reaction force, F). We present a model that predicts sagittal plane F direction as passing through a divergent point (DP) fixed in a reference frame attached to the person.

The Amplatzer duct occluder for PDA closure: indications, technique of implantation and clinical outcome.

Following its introduction into clinical practice, the Amplatzer duct occluder (ADO) has achieved a definite place in the armamentarium of the interventional cardiologist for the closure of moderate to large sized PDAs. The device combines ease of use, including retrievability and repositioning when required, and a high occlusion rate (>99% complete occlusion of PDA within 6 months of implant, with the majority of occlusions occurring within 24 hours of implant). Possible complications, such as device embolization, protrusion of the retention disc of the device into the aorta producing aortic obstruction, or obstruction of a branch pulmonary artery by the device are also uncommon and can be avoided by choosing the appropriate sized device (with the pulmonary end of the device being 2mm larger in diameter than the minimum measured ductal diameter), and paying scrupulous attention to technique of deployment.

Transhepatic approach for catheter interventions in infants and children with congenital heart disease.

Unlabelled: We report on our experience with transhepatic access for catheter interventions in six children (age range 2.5 months-9 years). Three had systemic venous anomalies, and one infant a femoral venous occlusion.

Palliative balloon dilation of native coarctation of the aorta in a preterm infant.

The role of balloon dilation for native coarctation in neonates is controversial, due to the relatively high recurrence rate. Balloon dilation may however provide adequate palliation in preterm infants, by relieving symptoms and allowing somatic growth until definitive surgical repair can be performed. We report successful balloon angioplasty, on 2 occasions, in a preterm neonate with coarctation of the aorta and associated left ventricular cardiomyopathy.

The effect of Escherichia coli heat-stable enterotoxin on protein kinase activity.

Isolated rat enterocytes were incubated with E. coli heat-stable enterotoxin or buffer alone and the protein kinase activity and cyclic GMP level determined on the particulate fraction or cytosol, respectively. In the control cells, particulate protein kinase activity and cyclic GMP concentration were at a maximum after 20 sec and 1 min of incubation, respectively.

Margarine and butter purchases of southern households.

Margarine and butter purchases of 1,061 southern households are reported. These families purchased twelve times as much margarine as butter. Medium-income households, those headed by grammar school-educated persons, households headed by farmers, those with an unemployed homemaker, and white households bought more margarine, on the average, than those in other categories.

Dairy product purchases by southern households.

Dairy product purchases of 1,061 southern households in 1972 and 1973 were analyzed. Quantities purchased increased with income. Whites bought more dairy products than blacks.

Abdominal metastases of primary intracranial yolk sac tumors through ventriculoperitoneal shunts: report of three cases.

Three cases of rare primary intracranial yolk sac tumor are reported. Two cases had a pineal location, whereas the third presented as a suprasellar mass. After the placement of ventriculoperitoneal shunts for relief of hydrocephalus, all of the patients developed metastases restricted to the peritoneum, as demonstrated by autopsy in one patient (Case 1) and clinical and radiographic evidence in two patients (Cases 2 and 3).

Microsurgical treatment of cerebral aneurysms at the bifurcation of the internal carotid artery.

With microtechnique, meticulous dissection and identification of critical anatomical structures become realities, contributing substantially to the improved results in the treatment of internal carotid artery bifurcation aneurysms.