The Potential Coexistence of Autoimmune Thyroid Diseases and Pediatric Vulvar .

Introduction: Vulvar lichen sclerosus (VLS), a chronic inflammatory skin disorder, often coexists with autoimmune thyroid disease (AITD). VLS presents with subtle symptoms including vulvar itching and discomfort. Clinically, a "Figure 8" pattern involving the labia minora, clitoral hood, and perianal region is often observed.

Female Sexual Function in Twin Pregnancy.

Introduction: The incidence of twin pregnancy is estimated at 1 per 80 single pregnancies. As the topic of sexual function among women with multiple pregnancy is insufficiently developed, we believe it is appropriate to raise this subject.

Methods: A prospective study was conducted on 100 women during subsequent trimesters of pregnancy.

The Impact of COVID-19 Pandemic on Female Sexual Function.

Introduction: The outbreak of the COVID-19 pandemic affected many aspects of life involving sexual functioning. Methods: This prospective, noninterventional, observational research was performed from July 2020 to August 2020, involving a total of 644 patients. Female sexual function index (FSFI) scores of those women were compared in relation to results of our research from April 2020.

Pediatric Vulvar Lichen Sclerosus-A Review of the Literature.

Vulvar lichen sclerosus (VLS) is a chronic inflammatory condition affecting the anogenital region, which may present in a prepubertal or adolescent patient. The most popular theories are its autoimmune and genetic conditioning, although theories concerning hormonal and infectious etiology have also been raised. The most common presenting symptoms of VLS is vulva pruritus, discomfort, dysuria and constipation.

Bioartificial endocrine pancreas: foreign-body reaction and effectiveness of diffusional transport of insulin and oxygen after long-term implantation of hollow fibers into rats.

Foreign body reaction of the liver, kidney, and subcutaneous tissue of rats after implantation of hollow fibers (HF) for 1, 3, 6, and 12 months and its influence on the effectiveness of diffusional transport of insulin and oxygen were investigated. The highest degree of fibrosis was observed after subcutaneous implantation of HF and the lowest degree after implantation into the kidney. Histochemical staining of the fibrous capsule showed a tissue-dependent domination of the collagenous fibrils.

Pancreatic islets obtained from pancreases with short-term exocrine atrophy disturbed morphology but normal in vitro response to various stimuli.

The morphology and function islets isolated from rat pancreases with short-term (16 days) exocrine atrophy was investigated. It was found that this type of atrophy induced changes in the shape and morphological structure of pancreatic islets. However, the function of isolate islets did not change, as investigated by the basal or glucose-stimulated secretion of insulin, glucagon and somatostatin, and by the CCK-stimulated secretion of insulin.

In vitro secretion of hormones from the islets of pancreas with acinar atrophy--influence of digestion with collagenase.

The release of insulin, glucagon and somatostatin from islets isolated by microdissection, and islets isolated by aid of different duration of collagenase digestion from pancreases with exocrine atrophy was assessed. Prior collagenase digestion caused an increased release of insulin and glucagon, but not somatostatin; also, the non-suppressibility of glucagon secretion despite high glucose concentration in the medium was characteristic for those islets. Additional data suggest that in the absence of intrinsic pancreatic proteases the nature of the damage conferred by collagenase to islet B- and A-cells is different.

Pancreatic perivascular lipid droplets--observations on adverse effects in the rat.

A standardized method for the isolation of so-called pancreatis perivascular lipid droplets (PPD) together with cells scattered on their surface is described. After implantation of PPD into the diabetic rat, a long term increase in glycaemia was found. After prior damage to PPD by the actions of enzymes a shortening of the post implantation survival period or even death of recipients within hours was observed.

A method for inducing exocrine atrophy and collecting juice from the nonatrophied pancreas in the rat.

A method for the long-term diversion of bile in the rat is described. It was used to induce complete and uniform pancreatic exocrine atrophy, as confirmed by a marked loss of weight of the gland, very low pancreatic tissue amylase, and by histological examination. The technique induces changes in endocrinal function of the pancreas, since it increases pancreas insulin by a factor of 2.

[Treatment of diabetes by implantation of isolated islands of Langerhans in semipermeable chambers].

The biological tolerance of chambers with membranes of regenerated cellulose and the influence of the implantation of isolated islets of Langerhans in these chambers on the blood sugar level of rats with experimental diabetes was investigated. It was concluded that retroperitoneal space offers the best conditions for the implantation of such chambers. The technique of implantation and the preparation of the chambers are the critical factors for the degree of foreign body reaction.

[Functional estimation of the isolated islands of Langerhans in semipermeable membrane chambers].

The possibility for the use of membranes of regenerated cellulose was tested for constructing semipermeable chambers for the cultivation and implantation of the isolated islets of Langerhans. The membranes of regenerated cellulose was well-permeable for insulin. An implantation for one month had no influence at the rate of diffusion of insulin.

Monitoring treatment of pulmonary carcinomas by serial determination of monoamine oxidase and diamine oxidase in blood serum.

We investigated monoamine oxidase (MAO--E.C. 1.