Publications by authors named "Bodo G C Wilkens"

Article Synopsis
  • Diffuse large B cell lymphomas (DLBCL) are aggressive cancers with complex genetics, making personalized treatments difficult to develop.
  • This study used the CRISPR/Cas9 system to knock out specific driver genes in DLBCL cells (OCI-LY3) to kill cancer cells while reducing side effects.
  • Results showed that targeting certain mutations decreased cancer cell viability and highlighted the potential of CRISPR/Cas9 in tailoring treatments for DLBCL, despite some challenges in efficiency and delivery.
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Genome editing using the CRISPR/Cas system has revolutionized the field of genetic engineering, offering unprecedented opportunities for therapeutic applications . Despite the numerous ongoing clinical trials focusing on genome editing, recent studies emphasize the therapeutic promise of gene editing using CRISPR/Cas technology. However, it is worth noting that the complete attainment of the inherent capabilities of therapy in humans is yet to be accomplished.

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