Publications by authors named "Bodil Ingerslev"
Article Synopsis
- The study aimed to assess how brain insulin affects glucose production in fasting humans, particularly focusing on the liver's glucose release through a controlled experiment.
- Nine healthy lean men participated in a crossover experiment, receiving either insulin via nasal spray or a placebo, while blood samples were taken to measure glucose levels.
- Results showed no significant differences in glucose production or turnover between the two conditions, suggesting that nasal insulin does not impact glucose production, although brain insulin's effects may depend on the body's metabolic state.
Objective: Angiopoietin-like protein-4 (ANGPTL4) is a circulating protein that is highly expressed in liver and implicated in regulation of plasma triglyceride levels. Systemic ANGPTL4 increases during prolonged fasting and is suggested to be secreted from skeletal muscle following exercise.
Methods: We investigated the origin of exercise-induced ANGPTL4 in humans by measuring the arterial-to-venous difference over the leg and the hepato-splanchnic bed during an acute bout of exercise.