Altered serum levels of neuronal proteins and antibodies to them in occupational diseases of the nervous system.

Aclinical and immunological examination of men with occupational pathology, including vibration disease (VD), occupational sensorineural hearing loss (SHL), and chronic mercury intoxication (CMI), was carried out. The comparison group consisted of men comparable in age and total work experience. Serum concentrations of neurotrophins (S100β, MBP, BDNF) and antibodies (ABs) to S100β and MBP proteins were determined by enzyme-linked immunosorbent assay.

[Assessment of the population and subpopulation composition of lymphocytes and their relationship in patients with sensorineural hearing loss].

Unlabelled: Study of the role of the phenotypic composition of lymphocytes, shifts in which can cause the development of various pathological processes, including sensorineural hearing loss, is an important area of modern research. Purpose of the study. To study the population and subpopulation composition of lymphocytes and their intercellular cooperation in persons with occupational sensorineural hearing loss.

[Comparative characteristics of cytokine and IgE levels in patients with bronchial asthma of professional and non-professional genesis].

A comparative evaluation of serum concentrations of cytokines and IgE production in patients with occupational bronchial asthma (BA) caused by exposure to the toxic-dust factor of the aluminum industry and patients with asthma of unprofessional genesis was carried out. A more pronounced pro-inflammatory response has been found in patients with occupational BA characterized by hyperproduction of IL-1b, IL-8. While for persons with non-professional asthma, a decrease in IL-1b, IL-5, IL-10 is characteristic.

[The pre-nosologic diagnostic of vibration disease.].

The vibration disease occupies one of leading places among occupational diseases. To decrease vibration pathology and to diminish number of cases of disability an early pre-clinical detection of harmful effect of vibration on organism of worker is needed. The purpose of study is to develop mode of diagnostic of early indications of health disorders of working individuals under local vibration impact.

[Mechanisms underlying changes in state of central nervous system pathways under exposure to metallic mercury].

The authors revealed mercury role in pathologic changes of central mechanisms underlying cerebral circulation in metabolic circle, associated with changes in central afferent pathways in thalamic region. Relationship was established between intensity of the diagnosed affect and changes in levels of antibodies to proteins S-100, general myeline protein, myeline-associated glycoprotein - that can indicate general neurodegeneration process. Antibodies level can serve as a marker of demyelination intensity in central pathways under exposure to neurotoxicants.

[Role ofneuroautoimmune integration in pathogenesis of vibration disease].

Clinical immunologic and electroneuromyographic examination covered patients with vibration disease. Registered- demyelination disorders on lower and upper limbs in vibration disease patients were associated with neurochemical changes in special neural structures (OBM, S-100 protein, DNA, AH-R, DA-R, Ser-R, GAMK-R). Direct proof of demyelination disorders in vibration disease patients are reliable correlation between levels of antibodies to OBM and conduction velocity in distal part of median nerve, in ulnar nerve from elbow bend and lower third of arm, and ulnar residual latency.

[The Impact of Industrial Vibration on Level of Antibodies to Regulatory Proteins of Nervous Tissue.].

The characteristic peculiarities in changing the levels of autoantibodies (AB) to the regulatory proteins of the nervous tissue have been revealed in the workers with a long-term working period and in the patients with Vibration-induced disease (VID). The levels of AB to MPM, Ser-R and β2GP were higher than the border of physiological level and the levels of AB to proteins GFAP and S-100 were lower than a physiological level in the workers with a long-term working period and in the patients with VID. Thereto, the higher levels of AB to GAMK-R were revealed in the patients with VID 2 times as often and 4 times as often compared with the workers with a long-term working period.

[Variability of some humoral immunity parameters in workers ofvarious industries in East Siberia].

Based on examination of workers exposed to various occupational factors in major industrial enterprises, the authors present results of comparative evaluation of some humoral immunity parameters. According to the study, Ig A, M and G are possible as available indicators in evaluation of functional resources being major risk factors for occupational health. Timely diagnosis and analysis of risk factors help to improve methodology of work groups certification in industrial enterprises, specification of innovation diagnostic tools and rehabilitation of working population.

[The evaluation of immunoregulatory markers in the course of neurointoxication by mercury over the post-exposure period].

There was executed the examination of patients with occupational chronic mercury intoxication in the post-exposure period after the exposure to metallic mercury vapor. 47 persons with an established diagnosis of chronic mercury intoxication (HMI) passed the laboratory and immunological examination in the period of exposure to metallic mercury vapor in a production environment. The average age of men accounted for 49.

[FEATURES OF CHANGES IN THE IMMUNE REACTIVITY IN EMPLOYEES IN MODERN PRODUCTION OF SULPHATE CELLULOSE].

There are reported changes in the indices of the immunoreactivity of the body in employees in modern productions of sulphate cellulose in dependence on the specificity of exposing factors of the production environment. At that the main adverse factor affecting the state of the immune reactivity of workers was found to be is air pollution of the working area with methyl-sulfur compounds in the pulping process, with chlorine and chlorine dioxide--in the process of bleaching, lime and limestone dust--in the process of caustic regeneration. There were shown differences in the character and severity of the immune response to the impact of different chemical compounds.

[ASSESSMENT OF THE CYTOKINE STATUS IN EMPLOYEES IN CONDITIONS OF CHRONIC EXPOSURE TO VINYL CHLORIDE].

In the article there are presented the results of the evaluation of cytokine profile in males working in the production of vinyl chloride (trained workers without signs of disorders of the neuropsychic status and persons with early signs of neurointoxication with vinyl chloride, characterized by asthenic (emotional lability) disorder with the autonomic dysfunction). There are established differences of pro- and anti-inflammatory responses in workers in dependence on the severity of disorders of the neuropsychic status. The most pronounced imbalance of cytokines was in workers with initial manifestations of neurointoxication with vinyl chloride.

[Neuroimmune endocrine relationships under exposure to local vibration in workers].

The studies prove that local vibration in workers alters parameters of immune, nervous, endocrine systems interconnected and demonstrating pathologic process degree. Findings are that workers with long length of service, having no health disorders, increased CNTF level is associated with high TSH, increased IgG level is connected with ACTH growth. In vibration disease, increase of neurospecific protein S-100β is associatedwith lower level of T4.

[Diagnostic value of neuronal auto-antibodies and neurodegeneration of central conduction tracts in exposure to metallic mercury vapors].

Stationary medical examination covered chemical production workers (47 individuals) with long length of service, exposed to metallic mercury vapors, and patients in remote stage of chronic mercury intoxication (51 individuals). The examination included registration of somatosensory evoked potentials and levels of neuronal antibodies. Analysis of results helped to reveal relationship between intensity of structural disorders involving central afferent conduction tracts and changes in levels of auto-antibodies to S-100 proteins, general myelin protein, myelin-associated glycoprotein--that can indicate general neurodegeneration process in central structures.

[On theory of sensory conflict under exposure to physical factors: main principles and concepts of formation].

The article presents results of longstanding studies on influence of occupational physical factors on workers health. Experimental and nature studies helped to justify basic concepts of sensory conflict theory, a trigger of occupational disease formation. Patients having occupational disease present disorders of cortex-subcortex relationships on diencephal level, central and peripheral regulatory mechanisms, central sensory mechanisms participation in pathologic processes development, changes in vegetative regulation on cerebral level, demyelination and axon demyelination changes in peripheral nerves of upper and lower limbs.

[The antibodies to neurohormonal anti-genes as a criterion of early diagnostic and neurointoxication in workers of chemical enterprises].

The examination was applied to enterprise workers laboring in conditions of vinyl chloride (79 patients), caustic soda (24 patients) and 10 patients with professional chronic mercury intoxication. The differences are established concerning manifestation of autoimmune reactions of personnel working in conditions of chronic effecting of vinyl chloride distinct of parameters characterizing autoimmune reactions of personnel working under impact of another neuro-toxicants (vapors of metallic mercury). The increasing of auto-antibodies to MAG was detected in healthy personnel and increasing of concentrations of auto-antibodies to protein S-100 and DNA was detected in personnel with initial manifestations of neuro-intoxication.

Inflammation mediators in employees in chronic exposure to neurotoxicants.

Objectives: The aim of this work is to perform comparative estimation of cytokines levels in chlorinated hydrocarbons and metallic mercury exposure in employees in the dynamics of neurologic disorders formation.

Material And Methods: The contents of cytokines IL-1β, IL-2, IL-4, IL-6, TNF-α, INF-Γ were determined in blood sera using the method of hardphasic immunoferment analysis. The significance of different average values was assessed using the parametric and non-parametric criteria - Student (in normal distribution) and Mann-Whitney tests taking into account the Bonferonni correction (non-difference from normal distribution).

[The role of neurotrophic factors in formation of vibration disease].

The authors studied serum levels of neurotrophic factors (brain-derived neurotrophic factor BDNF and ciliary neurotrophic factor CNTF) in workers exposed to vibration (workers with long length of service and without health disorders caused by vibration, patients with occupational limbs polyneuropathy, and vibration disease patients). Findings are that occupational vibration induces increased BDNF and CNTF serum levels in all groups examined. Increased levels of neurotrophic factors at early stages of pathologic process indicate their protective action, action of compensatory protective mechanisms.

[Occupational neurointoxications: patterns and mechanisms of formation].

The article covers results of long-standing study of clinical features of occupational neurointoxications in late period, and mechanisms underlying nervous system disorders in individuals working under long exposure to neurotoxic chemicals and in late period of occupational intoxications. With modern neurophysiologic, neuropsychologic, immunologic and biochemical diagnostic methods, the authors specified early manifestations of occupational disorders. Translation patterns of neurointoxications are specified.

[Detection of disordered immune responses to the chronic effects of vinyl chloride in the organism (clinical and experimental study)].

This paper considers the features of disorders of immunity in chronic exposure to vinyl chloride at work and in experimental animals. It is shown that one of the earliest and most sensitive indicators of the formation of the resistance of the organism employed in the manufacture of vinyl chloride, are: IgM, IL-1beta, TNF-alpha, autoantibodies to neurospecific proteins (S-100, Vd-Ca channels and DNA).

[Toxic encephalopathies in distant post-contact period of occupational neurointoxications (clinical and experimental studies)].

The article covers results of long-standing research on clinical peculiarities and course of toxic encephalopathy in distant period of occupational neurointoxications, on main concepts and pathogenetic steps of formation and progress of toxic encephalopathy. Through investigation covered firemen after exposure to complex of toxic chemicals and patients in post-contact period of chronic mercury intoxication. Modelling of chronic inhalation of metallic mercury vapors was performed.

[Topical problems of occupational allergic diseases nowadays].

The article covers materials on occupational allergic diseases prevalence in variable economic branches of Baikal area, if compared to the values in Russian Federation in general. The authors defined major etiologic factors resulting in allergic diseases, demonstrated that immune suppression is a major concept in occupational skin and respiratory system diseases, revealed immune response peculiarities in accordance with acting occupational allergen type.

[Neuroimmunological mechanisms of development of occupational nervous system lesions].

One hundred and fifty fire liquidators, including 68 persons with consequences of acute intoxication with a complex of toxic substances, were examined over time. The development of occupational nervous system injuries was shown to be followed by systemic immunological disorders. Following 8 years, the patients with occupational neurointoxication were found to have impaired processes of lymphocytic activation (higher lymphocytes expressing CD25 and CD95) in the presence of significant immunosuppression.

[Assessment of a carcinogenic risk to the population of Bratsk].

The paper provides data on the assessment of a carcinogenic risk to the population of Bratsk, a large industrial center. Long-term ambient air pollution with 3,4-benz(a)pyrene, formaldehyde, chromium, and other impurities causes the inadmissible level of a risk that has some differences for dwellers in some districts of the town. Clinical and immunological studies of an apparently healthy population revealed the tension of defensive immune mechanisms in the residents who were more exposed to pollution.

[Peculiarities of immunologic reactivity in workers exposed to various neurotoxic chemicals].

The author presents results of immunologic examination in workers contacting mercury, chlorinated hydrocarbons at work. Research revealed peculiarities of immune response of the workers to neurotoxic chemicals varying in chemical nature. Discussion covered a topic of pathogenetic value of hyperactivated inflammatory cytokines and increased levels of antibodies to nervous tissue antigens in occupational neurointoxications.

[Immunological responsiveness of mercury-exposed workers].

Immunological responsiveness was studied in 133 workers who were in contact with mercury and in 20 patients with chronic mercury intoxication. Changes were revealed in the cellular, humoral, and phagocytic links of immunity in healthy workers. The development of occupational neurointoxication was shown to be accompanied by the increased count of lymphocytes expressing the markers of late (CD95+ and HLA-DR+) and early (CD25+) activation in the presence of significant immunosuppression.