Publications by authors named "Boddapati Kalyani Bhardwaj"
Gambogic acid (GA), a xanthanoid compound, is derived from Garcinia Hanbury gamboge resin. Studying GA's DNA binding and targeting processes is crucial to understanding its tumor-targeting potentiality. This study used spectroscopic and in silico methods to investigate the GA-calf thymus DNA-binding interaction.
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- - The study focused on synthesizing and characterizing PEGylated graphene oxide (pGO) and pGO conjugated with a specific hormone peptide, investigating their interactions with human serum albumin (HSA) and calf thymus DNA (CT-DNA).
- - Nanoparticles were created using a modified method, and various spectroscopic and microscopic techniques confirmed their composition, size, and morphology, while the presence of the hormone peptide was validated through specific assays.
- - Binding analyses showed that pGO/pGO-FSH nanoparticles interact with HSA without altering its structure and demonstrated moderate binding affinity, with interactions involving hydrophobic and hydrogen bonding, also indicating that these nanoparticles bind to DNA.
Ovarian cancer is one of the leading causes of cancer-related deaths among women. The drawbacks of conventional therapeutic strategies encourage researchers to look for alternative strategies, including nanotechnology. Nanotechnology is one of the upcoming domains of science that is rechanneled towards targeted cancer therapy and diagnosis.
View Article and Find Full Text PDFLong non-coding RNAs (lncRNAs) are emerging regulators of cellular pathways, especially in cancer development. Among the lncRNAs, nuclear paraspeckle assembly transcript 1 (NEAT1) forms a scaffold for a nuclear body; the paraspeckle and aberrant expression of NEAT1 have been reported in breast and gynecologic cancers (ovarian, cervical, endometrial, and vulvar). Abundantly expressed NEAT1 in breast and gynecologic cancers generally contribute to tumor development by sponging its corresponding tumor-suppressive microRNAs or interacting with various regulatory proteins.
View Article and Find Full Text PDFOvarian cancer is typically diagnosed at an advanced stage and poses a significant challenge to treatment and recovery. Relapsed ovarian cancer and chemoresistance of ovarian tumor cells are other clinical challenges. Liquid biopsy is an essential non-invasive diagnostic test that evaluates circulating tumor cells and tumor DNA, as well as other blood markers that may be useful in guiding precision medicine.
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