Neural-Network-Based Adaptive Event-Triggered Asymptotically Consensus Tracking Control for Nonlinear Nonstrict-Feedback MASs: An Improved Dynamic Surface Approach.

In this article, the asymptotic tracking control problem for a class of nonlinear multi-agent systems (MASs) is researched by the combination of radial basis function neural networks (RBF NNs) and an improved dynamic surface control (DSC) technology. It's important to emphasize that the MASs studied in this article are nonlinear and nonstrict-feedback systems, where the nonlinear functions are unknown. In order to satisfy the requirement that all items in the controller must be available, the unknown nonlinearities in the system are flexibly approximated by utilizing RBF NNs technique.

Design, Synthesis, and Preliminary Immunological Studies of MUC1-Based Antitumor Vaccines Adjuvanted with - and -FSL-1.

Fibroblast stimulating lipopeptide 1 (FSL-1) is the ligand of TLR2 and TLR6 and can be used as the vaccine adjuvant to prepare antitumor vaccines. However, FSL-1 is a stereoisomeric mixture that contains the stereoisomer and stereoisomer, and it is still unclear which stereoisomer has better adjuvant activities. In this work, we designed and synthesized MUC1-based antitumor vaccines adjuvanted with the stereoisomers -FSL-1 and -FSL-1, which were synthesized from the stereoisomeric building blocks -Fmoc-PamCys-OH and -Fmoc-PamCys-OH, respectively.

Design of a MUC1-based tricomponent vaccine adjuvanted with FSL-1 for cancer immunotherapy.

MUC1 is an attractive target for cancer vaccines as a result of its over-expression and aberrant glycosylation pattern on many tumor cells. However, the low immunogenicity of MUC1 and immune tolerance have limited its application. Herein, we designed MUC1-based tricomponent antitumor vaccines adjuvanted with fibroblast stimulating lipopeptide 1 (FSL-1).

Natural Polysaccharides with Immunomodulatory Activities.

Natural polysaccharide is a kind of natural macromolecular which can be extracted from plants, fungi, algae, animals, and bacteria. The monosaccharide compositions and glucosidic bonds of polysaccharides from different origins vary substantially. Natural polysaccharides have been shown to possess complex, important and multifaceted biological activities including antitumor, anticoagulant, antioxidative, antiviral, immunomodulatory, antihyperlipidemic and antihepatotoxic activities.