[Current view on the issue of insufficient effectiveness of anti-VEGF therapy for age-related macular degeneration].

Due to the significant medical and social importance of neovascular (wet) age-related macular degeneration (wAMD), increasing the effectiveness of anti-VEGF therapy used to treat this disease is one of the high-priority problems in modern retinology. This article focuses on pathobiological aspects and clinical manifestations of incomplete responses to anti-VEGF therapy of wAMD, considers the proposed ways to improve the terminology and classification of responses to therapy, as well as the assessment of its correctness and effectiveness of the treatment. It also discusses the available ways to optimize anti-VEGF therapy and define the criteria of its termination in cases when the treatment proves to be futile.

[Anti-VEGF therapy for neovascular age-related macular degeneration: causes of incomplete response].

Neovascular age-related macular degeneration (nAMD) is one of the leading causes of decreased vision in the elderly population in many countries, including Russia. Anti-VEGF therapy is undoubtedly the «gold standard» of treatment for the disease, but its use in different patients is known to produce results with significant interindividual differences. This article reviews modern ideas about the clinical assessment of the degree of response to anti-VEGF therapy, possible reasons for its insufficient effectiveness (clinical, pharmacological, or related to nAMD pathogenesis), discusses the potential applications of the existing therapeutic strategies, and considers the prospects for the emergence of new strategies that could be used for solving that problem.

[Anti-VEGF therapy of wet age-related macular degeneration: analysis of patients lost to follow-up].

Unlabelled: Patients lost to follow-up (LTFU) are a well-recognized challenge, both in clinical trials and in real clinical practice.

Purpose: To study the reasons for patients receiving anti-VEGF therapy for «wet» age-related macular degeneration (wAMD) in clinical environment to cease monitoring in the clinic.

Material And Methods: This retrospective cohort study included patients with wAMD which received anti-VEGF therapy (ranibizumab, aflibercept) in the Ural State Medical University clinic from 2011 to 2019 (=241).

[Protocol of intravitreal drug delivery. Consensus of the Expert Counsil of Retina and Optic Nerve Diseases of the All-Russian Public Organasation «Association of Ophthalmologists»].

Intravitreal drug administration is a procedure that has become widespread in modern ophthalmology. However, there is no global consensus on certain aspects of this manipulation, and practitioners feel the need for guidelines. In the Russian Federation, until now, such a document was not available.

[Long-term outcomes of anti-angiogenic therapy for macular neovascular disorders].

Aim: to study long-term (≥2-year) RESULTS of ranibizumab treatment in patients with macular neovascular disorders.

Material And Methods: The study group included 27 patients (mean age±SD of 66.7±13.

[The influence of patient compliance with antiangiogenic therapy on its efficacy for neovascular age-related macular degeneration].

Purpose: To study the level of patient compliance with Ranibizumab therapy and affecting factors.

Material And Methods: Medical records of 76 patients aged from 50 to 86 years (mean age 70.7 +/- 9.

[Endoscopic methods for the correction of ureteral strictures].

The comprehensive examination and treatment of 80 patients aged 19 to 63 years with strictures of the ureteropelvic junction (UPJ) and ureter obstruction was performed. 23 patients underwent probing with ureteral stenting, 30 patients underwent balloon dilation of strictures under fluoroscopic guidance, 18 patients--endoureteropielotomy with "cold" knife, 9 patients underwent endoureteropielotomy using holmium laser. Correction of ureteral stricture with the removal of the stone was performed in 6 patients.

[Particular features of detection of patients with urogenital tuberculosis and their management].

The rate and trend in extrapulmonary tuberculosis (TB) incidence including urogenital tuberculosis (UTB) were estimated in population of the Sverdlovsk region for the last 25 years. Long-term results of treatment of 591 patients with different forms of UTB (renal parenchyma TB, tuberculosis papillitis, monocavernous and polycavernous renal TB, male genital TB) were studied. Ureter was involved in tuberculosis process in 24.

[Complex diagnosis of fragment injuries of the eye and orbit].

The paper presents data on the prevalence and pattern of fragment injuries of the eye and orbit in the Sverdlovsk Region in 2000-2004. It describes the authors' system for complex diagnosis of metallic foreign bodies, which is based on the wide use of electron location in combination with other clinical, instrumental, and special studies. The comparative results of treating patients with the standard and proposed system, which demonstrate the advantages of the latter in small-sized fragments in particular, are given.