[Lupus nephritis and thrombotic microangiopathy: A review].

Lupus nephritis (LN) is one of the most common organ-specific manifestations of systemic lupus erythematosus (SLE). Various clinical signs of LN develop in at least 50% of patients with SLE. In addition to LN, the spectrum of renal lesions associated with SLE also includes vascular pathology.

[Clinical characteristics and genetic profile of complement system in renal thrombotic microangiopathy in patients with severe forms of arterial hypertension].

Background: The spectrum of diseases characterized by the development of renal thrombotic microangiopathy (TMA) encompasses the malignant hypertension (MHT). TMA in MHT has conventionally been regarded as a variation of secondary TMA, the treatment of which is restricted to the stabilization of blood pressure levels, a measure that frequently fails to prevent the rapid progression to end-stage renal disease in patients. Nevertheless, there exists a rationale to suggest that, in certain instances, endothelial damage in MHT might be rooted in the dysregulation of the complement system (CS), thereby presenting potential opportunities for the implementation of complement-blocking therapy.

Recognition of granulocyte-macrophage colony-stimulating factor by specific S100 proteins.

Granulocyte-macrophage colony-stimulating factor (GM-CSF) is a pleiotropic myelopoietic growth factor and proinflammatory cytokine, clinically used for multiple indications and serving as a promising target for treatment of many disorders, including cancer, multiple sclerosis, rheumatoid arthritis, psoriasis, asthma, COVID-19. We have previously shown that dimeric Ca-bound forms of S100A6 and S100P proteins, members of the multifunctional S100 protein family, are specific to GM-CSF. To probe selectivity of these interactions, the affinity of recombinant human GM-CSF to dimeric Ca-loaded forms of 18 recombinant human S100 proteins was studied by surface plasmon resonance spectroscopy.

[Comparative characteristics of the complement system in patients with C3-glomerulopathy and atypical hemolytic uremic syndrome of chronic course who suffered an acute episode of thrombotic microangiopathy].

Aim: To compare changes in the complement system in C3-glomerulopathy (C3-GP) and atypical hemolytic uremic syndrome (aHUS) after the relief of an acute episode of thrombotic microangiopathy.

Materials And Methods: The study included 8 patients diagnosed with C3-GP and 8 with aHUS in remission. The blood levels of the complement system components were determined: C3, C4, C3a, C5a, factor H (CFH), factor B (CFB), membrane-attacking complex (MAC), antibodies to C3b (anti-C3b-AT), the level of hemolytic activity (CH50), the content of factor D (CFD) in the urine.

Approaches to the design of efficient and stable catalysts for biofuel reforming into syngas: doping the mesoporous MgAlO support with transition metal cations.

The mesoporous MgAlO support is promising for the design of efficient and stable to coking catalysts for natural gas and biofuel reforming into syngas. This work aims at doping this support with transition metal cations (Fe, Cr, Ti) to prevent the incorporation of Ni and rare-earth cations (Pr, Ce, Zr), loaded by impregnation, into its lattice along with providing additional sites for CO activation required to prevent coking. Doped MgAlMeO (Me = Fe, Ti, Cr) mesoporous supports prepared by the one-pot evaporation-induced self-assembly method with Pluronic P123 triblock copolymers were single-phase spinels.

Electrodeposited Ni-Mo coatings as electrocatalytic materials for green hydrogen production.

In this work, nanocrystalline nickel and nickel-molybdenum alloys were electrodeposited from electrolytes based on deep eutectic solvents. Eutectic mixtures of choline chloride with ethylene glycol (ethaline) and urea (reline) were used as typical representatives of deep eutectic solvents. The deposited Ni and Ni-Mo films were evaluated as potential electrocatalytic materials for green hydrogen production via electrolysis of alkaline aqueous solutions.

Model-Based Performance Analysis of Membrane Reactor with Ethanol Steam Reforming over a Monolith.

Membrane reactors (MR) with an appropriate catalyst are considered to be an innovative and intensified technology for converting a fuel into the hydrogen-rich gas with the simultaneous recovery of high-quality hydrogen. Characteristics of an asymmetric membrane disk module consisting of a gas-tight nanocomposite functional coating (Ni + Cu/NdWO mixed proton-electron conducting nanocomposite) deposited on a gas-permeable functionally graded substrate has previously been extensively studied at lab-scale using MRs, containing the catalyst in a packed bed and in the form of a monolith. The catalytic monolith consisted of a FeCrAl substrate with a washcoat and an Ni + Ru/PrCeZrO active component.

An Experimental Performance Study of a Catalytic Membrane Reactor for Ethanol Steam Reforming over a Metal Honeycomb Catalyst.

The present study deals with the combination of ethanol steam reforming over a monolithic catalyst and hydrogen separation by membrane in a lab-scale catalytic membrane reactor (CMR). The catalyst was comprised of honeycomb thin-walled Fechralloy substrate loaded with Ni + Ru/PrCeZrO active component. The asymmetric supported membrane consisted of a thin Ni-Cu alloy-Nd tungstate nanocomposite dense permselective layer deposited on a hierarchically structured asymmetric support.

Effect of Asymmetric Membrane Structure on Hydrogen Transport Resistance and Performance of a Catalytic Membrane Reactor for Ethanol Steam Reforming.

The performance of catalytic membrane reactors (CMRs) depends on the specific details of interactions at different levels between catalytic and separation parts. A clear understanding of decisive factors affecting their operational parameters can be provided via mathematical simulations. In the present paper, main results of numerical studies of ethanol steam reforming, followed by downstream hydrogen permeation through an asymmetric supported membrane, are reported.

[Thromboembolic complications in nephrotic syndrome].

This review devoted to the nephrotic syndrome (NS) subsequent thrombotic outcomes. The pathogenesis of hypercoagulation disorders that cause venous and arterial vascular system thrombosis are studied. Discussed procoagulant and anticoagulant mechanisms imbalance due to the anticoagulants natural urinal loss, affected by disfunction of the glomerular filter selective permeability, leading to high molecular weight liver-derived proteins (at least of the albumin size) leakage, fibrinolysis depression, excessive liver synthesis of plasma clotting cascade factors and platelet activation.

Atypical hemolytic-uremic syndrome as one of the causes of acute kidney injury in pregnant women.

Aim: Analysis of clinical manifestations, course and outcomes of obstetric aHUS.

Materials And Methods: 45 patients with aHUS development during pregnancy or immediately after childbirth were observed between 2011 and 2017, age from 16 to 42 years.

Results: All patients had AKI (serum creatinine 521,5±388,0 µmol/l, oliguria or anuria that required initiation of hemodialysis).

Adverse outcomes in obstetric-atypical haemolytic uraemic syndrome: a case series analysis.

The aim of this case series is to raise awareness of obstetric-related atypical haemolytic uraemic syndrome (aHUS) amongst obstetricians and gynaecologists. Data from 20 consecutive patients, aged 19-38, with obstetric-aHUS manifestation during or immediately after pregnancy are reported. Patients were diagnosed and treatment was initiated between 2012 and 2016.

[Complement System Abnormalities in Patients with Atypical Hemolytic Uremic Syndrome and Catastrophic Antiphospholipid Syndrome].

Background: The role of the alternative complement pathway (AP) abnormalities in the pathogenesis of aHUS is well studied. Clinical and morphological manifestations of atypical HUS and catastrophic APS are often similar. However, studies on the state of AP in patients with CAPS are virtually absent.

[Changes in the complement system in membranoproliferative glomerulonephritis].

Aim: To compare the clinical manifestations membranoproliferative glomerulonephritis (MPGN) in its idiopathic variant, lupus nephritis (LN), and C3 glomerulopathy (C3-GP), by comparing them with changes in the complement system.

Subjects And Methods: The clinic of nephrology followed up 42 patients with different types of MPGN in 2013 to 2015. The study included 35 patients divided into 3 groups: 1) 8 patients with C3-GP, 2) 13 with idiopathic MPGN; 3) 14 with Class IV LN.

[Alterations of the complement system in patients with catastrophic antiphospholipid syndrome].

Aim: To investigate alterations of the complement system in patients with catastrophic antiphospholipid syndrome (CAPS).

Subjects And Methods: Four patients (2 men aged 23 and 40 years and 2 women aged 39 and 58 years) diagnosed as having CAPS, including 3 patients with systemic lupus erythematosus and secondary antiphospholipid syndrome (APS) and 1 patient with primary APS, were examined. The activity of the complement components C1-C5 and total hemolytic activity were determined in all the patients at the moment of an acute episode and in 1 patient after treatment.

[Clinicomorphological characteristics of renal disorders in patients with genetic thrombophilia].

Aim: To characterize the course and clinicomorphological features of chronic glomerulonephritis (CGN) in patients with genetic thrombophilia.

Material And Methods: A clinical picture and evidence on renal biopsy from 25 patients (12 females, mean age 32 +/- 12 years and 13 males, mean age 36 +/- 8.8 years) admitted to hospital with diagnosis of chronic glomerulonephritis were analysed.

[Influence of cultivation temperature of Yersinia pseudotuberculosis on the immunobiological properties of lipopolysaccharide].

Aim: To study relationship between Yersinia pseudotuberculosis cultivation temperature and immunobiological properties of lypopolysaccharide (LPS).

Materials And Methods: LPS producing strain--Yersinia pseudotuberculosis 164/84 OX; experimental animal--guinea pigs, rabbits; methods--immunochemical (indirect hemagglutionation assay, RDP), physico-chemical (electrophoresis, gas-liquid chromatography), standard biochemical and statistical methods.

Results: It was established that increase of Yersinia pseudotuberculosis cultivation temperature from 10 degrees C to 37 degrees C was associated with attenuation of LPS toxicity in guinea pigs, decrease of its immunochemical activity and contents and degree of acylation of 3OH-14:0 hydoxyacid as well as amount of electrophoretically detected O-side chains.

[The clinical picture and course of Lyme disease in children in the city of Krasnoyarsk].

The paper describes the clinical picture and course of Lyme's disease (LD) in children from the city of Krasnoyarsk. The disease was ascertained to have a wide range of clinical manifestations: cutaneous changes, visceral abnormalities, involvement of the locomotor and nervous systems into the pathological process. The paper characterizes possible late consequences of the prior disease, which justifies the necessity of timely diagnosis and treatment of LD in children.

[The nature of glycogen complexing with iodine in the presence of CaCl2].

The absorption and dichroism of muscle glycogen--iodine complexes depending on CaCl2 concentration were studied. It was shown that besides intensification of glycogen staining with iodine, high concentrations of CaCl2 cause destabilization of the alpha-glucan helix as well as disturbances in the formation of a specific chromophore of the iodine-glycogen complex which manifest themselves as a loss of dichroism. The stained chromophore formed by a simultaneous decrease in the dichroic absorption seems to be generated in the non-helical regions of the glycogen molecule and is thus nonspecific.