Workflow for detecting biomedical articles with underlying open and restricted-access datasets.

To monitor the sharing of research data through repositories is increasingly of interest to institutions and funders, as well as from a meta-research perspective. Automated screening tools exist, but they are based on either narrow or vague definitions of open data. Where manual validation has been performed, it was based on a small article sample.

fiddle: a tool to combat publication bias by getting research out of the file drawer and into the scientific community.

Statistically significant findings are more likely to be published than non-significant or null findings, leaving scientists and healthcare personnel to make decisions based on distorted scientific evidence. Continuously expanding ´file drawers' of unpublished data from well-designed experiments waste resources creates problems for researchers, the scientific community and the public. There is limited awareness of the negative impact that publication bias and selective reporting have on the scientific literature.

Highly structured, partner-sex- and subject-sex-dependent cortical responses during social facial touch.

Touch is a fundamental aspect of social, parental and sexual behavior. In contrast to our detailed knowledge about cortical processing of non-social touch, we still know little about how social touch impacts cortical circuits. We investigated neural activity across five frontal, motor and sensory cortical areas in rats engaging in naturalistic social facial touch.

PhotoAgeClock: deep learning algorithms for development of non-invasive visual biomarkers of aging.

Aging biomarkers are the qualitative and quantitative indicators of the aging processes of the human body. Estimation of biological age is important for assessing the physiological state of an organism. The advent of machine learning lead to the development of the many age predictors commonly referred to as the "aging clocks" varying in biological relevance, ease of use, cost, actionability, interpretability, and applications.

Targeted delivery of chemotherapy using HSP90 inhibitor drug conjugates is highly active against pancreatic cancer models.

The lack of effective treatment modalities is a major problem in pancreatic cancer (PCa), a devastating malignancy that is nearly universally driven by the "undruggable" KRAS and TP53 cancer genes. Poor tumor tissue penetration is the major source of resistance in pancreatic cancer where chemotherapy is the mainstay of treatment. In this study we exploited the selective tumor-targeting properties of the heat shock 90 protein inhibitors as the vehicle for drug delivery to pancreatic tumor tissues.

Screening of Conditionally Reprogrammed Patient-Derived Carcinoma Cells Identifies ERCC3-MYC Interactions as a Target in Pancreatic Cancer.

Purpose: Even when diagnosed prior to metastasis, pancreatic ductal adenocarcinoma (PDAC) is a devastating malignancy with almost 90% lethality, emphasizing the need for new therapies optimally targeting the tumors of individual patients.

Experimental Design: We first developed a panel of new physiologic models for study of PDAC, expanding surgical PDAC tumor samples in culture using short-term culture and conditional reprogramming with the Rho kinase inhibitor Y-27632, and creating matched patient-derived xenografts (PDX). These were evaluated for sensitivity to a large panel of clinical agents, and promising leads further evaluated mechanistically.

Vocalization-whisking coordination and multisensory integration of social signals in rat auditory cortex.

Social interactions involve multi-modal signaling. Here, we study interacting rats to investigate audio-haptic coordination and multisensory integration in the auditory cortex. We find that facial touch is associated with an increased rate of ultrasonic vocalizations, which are emitted at the whisking rate (∼8 Hz) and preferentially initiated in the retraction phase of whisking.

The representation of social facial touch in rat barrel cortex.

Controlled presentation of stimuli to anesthetized [1] or awake [2] animals suggested that neurons in sensory cortices respond to elementary features [3, 4], but we know little about neuronal responses evoked by social interactions. Here we investigate processing in the barrel cortex of rats engaging in social facial touch [5, 6]. Sensory stimulation by conspecifics differs from classic whisker stimuli such as deflections, contact poles [7, 8], or textures [9, 10].

Neurochemical characterization of the striatum and the nucleus accumbens in L-type Ca(v)1.3 channels knockout mice.

L-type Ca(v)1.3 channels control the autonomous pacemaking of the substantia nigra (SN) dopamine (DA) neurons, which maintains the sustained release of DA in the striatum, its target structure. The persistent engagement of L-type channels during pacemaking might lead to increased vulnerability to environmental stressors or degenerative processes, providing a mechanism for the development of Parkinson's disease (PD).

An Analytical Technique to Elucidate Field Impurities From Manufacturing Uncertainties of an Double Pancake Type HTS Insert for High Field LTS/HTS NMR Magnets.

This paper addresses adverse effects of dimensional uncertainties of an HTS insert assembled with double-pancake coils on spatial field homogeneity. Each DP coil was wound with Bi2223 tapes having dimensional tolerances larger than one order of magnitude of those accepted for LTS wires used in conventional NMR magnets. The paper presents: 1) dimensional variations measured in two LTS/HTS NMR magnets, 350 MHz (LH350) and 700 MHz (LH700), both built and operated at the Francis Bitter Magnet Laboratory; and 2) an analytical technique and its application to elucidate the field impurities measured with the two LTS/HTS magnets.

Field Mapping, NMR Lineshape, and Screening Currents Induced Field Analyses for Homogeneity Improvement in LTS/HTS NMR Magnets.

This paper describes two general methods: field map processing and NMR lineshape analysis, that we are currently using for the on-going research of field improvement techniques specifically applied to our 700 MHz LTS/HTS NMR magnet. The validity of the methods is verified with comparison between calculations and experiments. Also, a simple but effective analysis has been used to identify the principal source of a remanent magnetic field measured in the bore of the 700 MHz LTS/HTS NMR magnet: the Screening Current induced Field (SCF) from the 100-MHz HTS insert, comprised of 48 double pancake coils, each wound with Bi2223 tape.

Development of a 700 MHz low-/high- temperature superconductor nuclear magnetic resonance magnet: test results and spatial homogeneity improvement.

For the first time in nuclear magnetic resonance (NMR) magnet development, a magnet configuration comprising an insert wound with high-temperature superconductor (HTS) and a background-field magnet wound with low-temperature superconductor (LTS) has been proven viable for NMR magnets. This new LTS/HTS magnet configuration opens the way for development of 1 GHz and above NMR magnets. Specifically, a 700 MHz LTS/HTS NMR magnet (LH700), consisting of a 600 MHz LTS magnet (L600) and a 100 MHz HTS insert (H100), has been designed, built, and successfully tested, and its magnetic field characteristics were measured and analyzed.

A 0.6 T/650 mm RT Bore Solid Nitrogen Cooled MgB Demonstration Coil for MRI-a Status Report.

Aiming to demonstrate feasibility and practicality of a low cost superconducting MRI magnet system targeted for use in small hospitals, rural communities and underdeveloped countries, MIT-Francis Bitter Magnet Laboratory has developed a 0.6 T/650 mm room temperature bore demonstration coil wound with multifilament MgB conductor and cooled via an innovative cryogenic design/operation. The coil is to be maintained cold by solid nitrogen kept in the solid state by a cryocooler.

[Efficacy of computer tomography in locally disseminated non small cell lung cancer].

The results of computed tomography (CT) staging and surgical data have been compared to assess the former in diagnosing localized lung cancer. The study included 79 patients with locally advanced non-small cell lung cancer who had been treated by surgery. Local invasion was adequately diagnosed by CT in 67 (84.

[Endovascular embolization of arteriovenous fistulas of the lungs (a review of the literature and our own data)].

The authors analyze the literature data and their own experience in endovascular closure of arteriovenous lung fistulas: 20 fistulas were closed in 12 patients, in whom transcutaneous catheterization of the pulmonary artery was performed. Large-frame angiopulmonography made it possible to reveal 10 common arteriovenous lung fistulas (7 single and 3 multiple ones). Afterwards the diagnostic procedure was turned into a therapeutic one.

[Endovascular embolization of arteriovenous lung fistulas (review of literature and own results)].

The authors analyze the literature data on and their own experience in endovascular closure of arteriovenous lung fistulas: 20 fistulas were closed in 12 patients, in whom transcutaneous catheterization of the pulmonary artery was performed. Large-frame angiopulmonography made it possible to reveal 10 common arteriovenous lung fistulas (7 single and 3 multiple ones). Afterwards the diagnostic procedure was turned into a therapeutic one.