Publications by authors named "Bobby Zhao Sheng Lo"
Background: Perianal complications in patients with Crohn's disease are common and have a negative impact on the patients' quality of life. Data about the long-term disease course of perianal Crohn's disease in the era of biological treatment are limited. In this population-based cohort study, we sought to investigate the occurrence, clinical risk factors, and disease course of perianal disease.
View Article and Find Full Text PDFObjective: IBS is associated with an intestinal dysbiosis and faecal microbiota transplantation (FMT) has been hypothesised to have a positive effect in patients with IBS. We performed a randomised, double-blind placebo-controlled trial to investigate if FMT resulted in an altered gut microbiota and improvement in clinical outcome in patients with IBS.
Design: We performed this study in 52 adult patients with moderate-to-severe IBS.
Article Synopsis
- Inflammatory bowel disease (IBD) includes Crohn's disease and ulcerative colitis, but its molecular causes are not well understood, especially since many associated genetic variations are found in non-coding regions.
- Researchers studied transcription start sites (TSSs) and enhancers in the colon of 94 IBD patients and controls, discovering that IBD-related genetic variations are closely linked to specific gene regulation patterns.
- With findings indicating that only 35 TSSs can differentiate between active Crohn's disease, ulcerative colitis, and controls with 85% accuracy, this research lays the groundwork for better understanding the genetics and molecular mechanisms of IBD.