Publications by authors named "Bobbie Schneider"
Article Synopsis
- The mitochondria-associated membrane (MAM) is a specialized area of the endoplasmic reticulum (ER) that helps in the transfer of ions, lipids, and metabolites between the ER and mitochondria.
- The study reveals that a process called palmitoylation, which involves the attachment of fatty acids to proteins, helps ER-localized proteins like TMX and calnexin to become more concentrated in the MAM.
- Disrupting palmitoylation through mutations or chemical interference prevents proper positioning of these proteins in the MAM, highlighting the importance of palmitoylation for the function of certain ER proteins.
In primate cells, assembly of a single HIV-1 capsid involves multimerization of thousands of Gag polypeptides, typically at the plasma membrane. Although studies support a model in which HIV-1 assembly proceeds through complexes containing Gag and the cellular adenosine triphosphatase ABCE1 (also termed HP68 or ribonuclease L inhibitor), whether these complexes constitute true assembly intermediates remains controversial. Here we demonstrate by pulse labeling in primate cells that a population of Gag associates with endogenous ABCE1 within minutes of translation.
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