Publications by authors named "Bobak D Kechavarzi"

The massive genomic data from The Cancer Genome Atlas (TCGA), including proteomics data from Clinical Proteomic Tumor Analysis Consortium (CPTAC), provides a unique opportunity to study cancer systematically. While most observations are made from a single type of genomics data, we apply big data analytics and systems biology approaches by simultaneously analyzing DNA amplification, mRNA and protein abundance. Using multiple genomic profiles, we have discovered widespread dosage compensation for the extensive aneuploidy observed in TCGA breast cancer samples.

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Article Synopsis
  • The study investigates how the regulation of the endoplasmic reticulum (ER) stress-response affects renal tubule dysfunction during diabetes in OVE26 type-1 diabetic mice, which is crucial for understanding diabetic nephropathy progression.
  • Key ER stress chaperones GRP78, GRP94, and PDI showed increased levels in older diabetic mice's cortical tubules, while younger mice had decreased PDI levels, indicating age-related differences in ER stress responses.
  • Additionally, the study found that the activation of PERK and upregulation of the proapoptotic factor CHOP were significant in the tubules of diabetic mice, suggesting their roles in cell apoptosis and matrix protein production in diabetes.
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