A novel carotid device for embolic diversion: lessons learned from a "first in man" trial in patients with atrial fibrillation.

Purpose: This study was designed to investigate a novel device that was developed to direct emboli away from the internal carotid artery to the external carotid artery to prevent embolic stroke while avoiding the necessity for anticoagulation with warfarin.

Methods: A stent-like, self-expandable filter was developed consisting of fine cobalt alloy mesh. After promising preclinical animal testing, the device was implanted into the common carotid artery extending into the external carotid artery in three patients with atrial fibrillation, each of whom were at high-risk for cerebral emboli and were suboptimal candidates for anticoagulation.

A novel endovascular device for emboli rerouting: part I: evaluation in a Swine model.

Background And Purpose: The feasibility and safety of a novel endovascularly delivered tubular mesh designed to reroute emboli away from a critical artery as a means of ischemic stroke prevention was tested in vitro and in vivo.

Methods: Emboli rerouting efficacy was assessed in vitro. Perfusion through the external femoral artery that was jailed by the device, cellular proliferation rate over the jailing mesh, and the resulting tissue coverage of the orifice were assessed in the swine iliofemoral bifurcation.

Similarity of the swine vasculature to the human carotid bifurcation: analysis of arterial diameters.

Purpose: We assessed the similarities of the iliac bifurcation in two breeds of swine to the known human carotid bifurcation, in order to assess its applicability as a preclinical model of the human carotid bifurcation.

Materials And Methods: Mixed-Landrace crossbreed (domestic; n = 66) and Yucatan miniswine (Yucatan; n = 13) were studied. The diameters of the iliac bifurcation arteries were measured from angiographic pictures, the relations between the arterial diameters and the animal's weight assessed, and diametrical ratios calculated.

Hemodynamic evaluation of embolic trajectory in an arterial bifurcation: an in-vitro experimental model.

Background And Purpose: Despite the importance of embolism as a major cause of brain infarction, little is known about the hemodynamic factors governing the path large emboli tend to follow. Our aim was to test in vitro, whether hemodynamic parameters other than flow ratios between bifurcation branches may affect the distribution of embolic particles in a Y-shaped bifurcation model, used as an analogue to an arterial bifurcation.

Methods: In vitro experiments were conducted using suspensions of sphere-shaped particles (0.