The treatment of eyelid malposition following septal reset blepharoplasty.

The authors have developed a systematic approach to treating eyelid malposition secondary to septal reset blepharoplasty. A key treatment factor is appropriate timing of interventions, which includes initiating treatment with nonsurgical interventions. Although patients who are unresponsive to nonsurgical measures may express a strong desire to surgically correct the eyelid malposition early on, surgical interventions before 3 to 6 months after the initial surgery can, in many instances, worsen the result.

Chronic subperiosteal hematic cyst formation twelve years after orbital fracture repair with alloplastic orbital floor implant.

An 89-year-old female patient with a history of a left orbital floor fracture repair with synthetic implant 12 years prior, presented with a three-week history of blurry vision, inferior conjunctival chemosis and proptosis of the left eye. CT scan revealed a well-circumscribed subperiosteal lesion with superior elevation of the orbital floor implant. The patient underwent transconjunctival orbital surgery with removal of the implant and drainage of the subperiosteal hemorrhagic cyst.

Toxicity and dose-response studies of 1alpha-hydroxyvitamin D2 in a retinoblastoma xenograft model.

Background: Although calcitriol (1,25-dihydroxycholecalciferol) and vitamin D(2) inhibit retinoblastoma growth in the athymic (nude) mouse xenograft (Y-79 cell line) model of retinoblastoma, they can cause severe toxicity.

Objective: To examine the toxicity of and dose-dependent response for the inhibition of tumor growth for 1alpha-hydroxyvitamin D(2) (1alpha-OH-D(2)), an analogue with reduced systemic toxicity, in the athymic Y-79 mouse model.

Methods: Mice were randomized into treatment and control groups for 5-week toxicity and dose-response studies.