Publications by authors named "Boae Choi"
Aims: Pro-inflammatory response of vascular smooth muscle cells (VSMCs) is triggered by endothelial damage and a causative step for thrombosis and neointimal thickening in the injured arterial vessels. Therefore, we investigate a role of cytosolic Hsp60 as a novel pro-inflammatory mediator in VSMCs.
Methods And Results: Hsp60 was detected in the cytosol of VSMCs.
Article Synopsis
- Cytoplasmic Hsp60, a mitochondrial chaperonin encoded by nuclear genes, plays a critical yet underexplored role in cell signaling related to survival pathways.
- The study reveals that cytosolic Hsp60 interacts directly with IKKalpha/beta, promoting activation of the IKK/NF-kappaB survival pathway in response to TNF-alpha.
- Blocking or reducing Hsp60 leads to decreased NF-kappaB activation and increased cell death, while enhancing its expression boosts survival signals, indicating it may be a key regulator in cell survival through the NF-kappaB pathway.